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Showing 1 to 20 of 55 for “"oxidative stress response"”.
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Regulation of The Oxidative Stress Response By Arid1A
… cancers.</p> <p> In this study, drug responses between <em>ARID1A</em>-wildtype and <em>ARID1A</em>-mutant cell lines were compared using the ‘Genomics of Drug Sensitivities in Cancer’ database. From this analysis, I found that <em>ARID1A</em>-mutant cell lines are more sensitive to …
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Role of estrogen receptor α and oxidative stress response proteins in the central nervous system
Made available in DSpace on 2014-09-16T17:23:57Z (GMT). No. of bitstreams: 3 Alicia_Dietrich.pdf: 2753057 bytes, checksum: 8fb8adbb98f08ad8b2b6b9a75a83fb3b (MD5) Dietrich_Alicia.docx: 4513759 bytes, checksum: 5942faabd81c4f91753707374679c5ad (MD5) license.txt: 4065 bytes, checksum: …
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Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory
… a Sir2 dependant manner, and may play a role in oxidative stress resistance. Oxidative damage that accumulates in cells during normal aging contributes to a variety of diseases and pathologies, and can result in an increase in age specific mortality. Accordingly, the oxidative stress theory of …
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The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans
… is critical for the survival of an organism. Oxidative stress is an adverse state in which reactive oxygen species (ROS) accumulate to a harmful level and, if left unresolved, can lead to cellular dysfunction and organismal disease. Sophisticated detoxification systems, characterized by a …
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Microarray data analysis methods and their applications to gene expression data analysis for Saccharomyces cerevisiae under oxidative stress
Oxidative stress is a harmful condition in a cell, tissue, or organ, caused by an imbalance between reactive oxygen species or other oxidants and the capacity of antioxidant defense systems to remove them. These oxidants cause wide-ranging damage to macromolecules, including proteins, lipids, DNA …
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The Effect of Condensed Tannins on Bacterial Diversity and Metabolism in the Intestinal Tract
… because they generate hydrogen peroxide. The oxidative stress response helps E. coli strains to overcome this inhibitory effect.
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MicroRNA Function in Cellular Stress Response
… and responding to changing environments and stress conditions as for viability or development. In this dissertation, two studies are presented: The first study demonstrates a role for microRNA in the regulation of oxidative stress response in erythroid cells and the functional consequences of …
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Functional Characterisation of the Eukaryotic Translation Elongation Factor 1Bγ in Aspergillus fumigatus; A Proteomic Systems Approach
… but also that it plays a key role in the oxidative stress response and may be involved in actin cytoskeleton organisation. Phenotypic analysis demonstrates that an elfA deficient strain (A. fumigatus ΔelfA) was significantly more sensitive to the oxidants H2O2 (> 1 mM) (p = 0.0003), …
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Molecular and Epidemiological Studies of Trichoderma aggressivum f. europaeum
… aggressivum in vitro. Proteins involved in the oxidative stress response were upregulated in T. aggressivum in both treatments. In vivo the production of oxidative stress response proteins may be part of the ability of T. aggressivum to resist inhibition by the microbial population of mushroom …
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Effects of Acute Heat and Oxidative Stress on the Hepatic Expression of Orexin and Its Related Receptors
… we sought to determine the effects of heat and oxidative stress using hydrogen peroxide (H2O2) and 4-hydroxynonenal (4-HNE) on the hepatic expression of ORX and ORXR1/2 in the avian species. Overall, heat stress significantly down regulated the expression of ORX, and ORXR1/2 mRNA and pro1tein in …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… in target cells, interaction with estrogen response element (ERE)-containing DNA, recruitment of coregulatory proteins, and modification of estrogen responsive genes. Because DNA-induced conformational changes in ERalpha structure alter complex formation, we were interested in identifying …
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Microbial Diversity in the Human Mouth: Dominant Genera and their Interactions.
… and their regulation and roles within response pathways in oral microbes is an interesting area of research to pursue, as it could give valuable insight into the changing genetic and potentially physiological state of oral microbes. An evaluation of oral microbial diversity performed …
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The Development of a Bacterial Biosensor Designed to Detect Oxidative Chemicals in Water: Correlating Sensor Relevance to Mammalian Brain Cells and Assessing Bacterial Cell Immobilization Strategies
Oxidative stress-inducing chemical contamination in the environment is a significant concern for public health. The depletion of antioxidants by these chemicals results in oxidative stress which may cause detrimental effects in many cell types. For example, multiple stress responses may be …
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Biomarkers of oxidative stress in atrazine-treated honey bees: A laboratory and in-hive study
… to the common-use herbicide atrazine elicit oxidative stress in non-target insects; however, little information is currently available on the exposure risk of atrazine to honey bees. This project examined biochemical and molecular oxidative stress response markers of honey bees following …
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UNDERSTANDING THE MOLECULAR MECHANISM LINKING ATM TO METABOLIC REGULATION.
… acts as a master regulator of the DNA damage response, leaving A-T patients highly predisposed to cancers. In addition to its classical role in orchestrating the DNA damage response, recent evidence reports a role for ATM in cellular metabolism, oxidative stress response and insulin signaling. …
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Modulation of Nocturnin Phosphatase Activity through the Disordered Amino Terminus
… high fat diet and confers a protective effect to oxidative stress in HEK cells. Modeling of full-length Nocturnin reveals a partially structured amino terminus that is disparate from its CCR4 family members. I show that Nocturnin functions as a phosphatase, catalyzing the removal of the …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
… the work presented here was to characterise the response of A. fumigatus and C. albicans to caspofungin. The results obtained demonstrated that caspofungin has potent anti-fungal activity and retards fungal growth but that the response of fungi to this drug is influenced by a variety of …
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Bioremediation of arsenic and cadmium in a Populus tremula x Populus alba mutant
… control poplars, suggesting it has a reduced oxidative stress response when exposed to high levels of arsenic and cadmium. This low hydrogen peroxide content was not due to reduced arsenic and cadmium accumulation in fuzzy trees, as they did not accumulate different amounts of arsenic or …
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A Stress-Induced TRNA Depletion Response Mediates Codon-Based Translational Repression and Growth Suppression
… can become fragmented upon various cellular stresses, generating tRNA-derived RNA fragments (tRFs). Though this process has been observed for numerous cellular stresses and in many species ranging from plant cells to yeast and human cells, it is still poorly characterized and understood. Such …
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The impact of a single nucleotide polymorphism in fusA1 on biofilm formation and virulence in Pseudomonas aeruginosa
… between sulfur metabolism, iron uptake and the oxidative stress response. In summary, the work presented in this dissertation highlights the susceptibility of fusA1 to spontaneous mutation and identifies a novel role for EF-G in bacterial virulence and antibiotic sensitivity, both of which have …
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