Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 204 for “"oxidative phosphorylation"”.
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS plays a critical role in the pathogenesis and …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation is that </strong><strong>OXPHOS plays a critical …
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The Role of Potassium Nutrition, Carbohydrate Translocation, and Oxidative Phosphorylation in Tomato Ripening
Made available in DSpace on 2014-12-10T17:53:08Z (GMT). No. of bitstreams: 1 6808086.pdf: 4284462 bytes, checksum: 4b9f34f1d35a75a2be7f3d11e24f73e1 (MD5) Previous issue date: 1967
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Increased Oxidative Phosphorylation In An Ipsc- Derived Model of Rothmund-Thomson Syndrome Associated Osteosarcomagenesis
… During differentiation, increased oxidative phosphorylation related genes, specifically transcription of genes which encode complex I of the electron transport chain, were upregulated. We next demonstrated that the observed transcriptional changes led to phenotypic changes in enzyme …
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… contributed to protein stability of MDM2 through phosphorylation. Inhibition of AKT leads to decrease in MDM2 Ser166 phosphorylation and increase mitochondria localisation in TKI-resistant cells. Collectively, we describe a novel observation that altered metabolism and TKI resistance in cancer …
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Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans
… tissues. Mitochondrial ATP production by oxidative phosphorylation (OXPHOS) is known to play a critical regulatory role in glucose stimulated insulin secretion (GSIS). The overall aim of this thesis was to explore the influence of genetic and epigenetic variation on OXPHOS, islet function …
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Interactions with bioenergetics by the mitochondria-targeted anti-apoptotic imidazole fatty acid derivative ‘TPP-IOA’.
… critical functions in aerobic ATP production via oxidative phosphorylation, and yet little is known about TPP-IOA’s interaction with mitochondrial energetics. This is an important consideration for TPP-IOA’s potential future therapeutic utility, as avoiding interference to mitochondrial energetics …
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A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection
… parameters of mitochondrial morphology, oxidative phosphorylation, glycolysis and ATP metabolism, in mock, HSV-2 WT and HSV-2 pUL16 null mutant (Δ16), infected human keratinocytes (HaCaT). Mitochondria in WT infected cells exhibited elongated morphology contributing to a more tubular …
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Transcription Regulates Biased Mitochondrial DNA Inheritance
… for cellular respiration and ATP production by oxidative phosphorylation. Respiration is the preferred method for creating mitochondrial membrane potential, which is important for the import of nuclearly encoded proteins into the mitochondrion as well as supporting oxidative phosphorylation. …
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Studie van het celdoodproces in candida albicans
… them are related to mitochondrial respiration or oxidative stress (POR1, CAT2, PGA3, TRX1), two are involved in nutrient sensing (GPR1, SNF31), one has an unknown function (IPF2973), one is involved in stress response (DDR48). The succeptibility of Saccharomyces cerevisiae to the antimicrobial …
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Mitochondrial Protein Expression in Natural and Induced Forms of Canine Dilated Cardiomyopathy
… mitochondrial proteins were mainly related to oxidative phosphorylation, but also included other elements of primary energy and other types of metabolism, antioxidant defense and programmed cell death. Maladjustment in proteins associated to energy likely indirectly reflect changes in other …
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Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
… respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.
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Ozone Inactivation of Listeria Monocytogenes
… L. monocytogenes requires SOD for survival under oxidative stress as a trigger of the detoxification process. Ozone injury and recovery studies showed that L. monocytogenes required RNA and protein synthesis and oxidative phosphorylation for cellular repair from ozone injury. The cell wall was not …
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Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins
… in the synthesis of ATP through a process called oxidative phosphorylation. The enzymes that make up the subunits of oxidative phosphorylation in humans and yeast are encoded by both nuclear DNA and in mitochondrial DNA. As such the mitochondrion has retained its own translational system to …
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Identification and characterization of genetic markers and metabolic pathways controlling net feed efficiency in beef cattle.
… in Lirnousin x Jersey animals, b) mitochondrial oxidative phosphorylation enzyme assays in high and low NFE cattle, and c) 2-dimensional fluorescent gel electrophoresis (DIGE) proteomics analysis of mitochondrial proteins. For the cattle QTL mapping, the results from a previous trial were …
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Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
… production. Upregulation of proteins involved in oxidative phosphorylation and down regulation of proteins involved in glycolysis implied specific alternations of primary metabolism in senescent cells. This metabolic shift is the opposite of the well-known ‘Warburg effect’ which is an observation …
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Achieving High Replication Fidelity by Intricate Communication between Two Active Sites and Efficient Use of Available Cofactors in Human Mitochondrial DNA Polymerase
… ATP for cellular energy through the process of oxidative phosphorylation. Each mitochondrion contains many copies of its own genome. Proper maintenance of mitochondrial genome is important for proper function as mutations and deletions on mitochondrial DNA impairs oxidative phosphorylation and …
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PKCε and cardioprotection : an exploration of putative mechanisms
… including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is regarded as a key step in the initiation of an apoptotic cascade. However, brief pore opening may be beneficial …
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