Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"oxidative damage"”.
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Oxidative damage to recombinant proteins during production
… their properties; among these modifications, oxidative damage is one of the most ubiquitous. Oxidative damage, however, is only occasionally considered as a "quality concern" since it rarely detectable using standard biochemical techniques. The production of an oxidatively-sensitive protein, …
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Practical Applications of Molecular Modeling Pertaining to Oxidative Damage and Disease
… applications in studying human disease models, oxidative damage, and other biomolecular processes that are otherwise not easily observed by experiment alone. Within this document, we study seven different such systems. This includes the mode of inhibitor binding to the enzyme monoamine oxidase …
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The Roles of Peroxynitrite and Superoxide in Oxidative Damage to E. Coli
Peroxynitrite (ONOO$\sp{-}),$ a toxic biomolecule produced from the reaction of superoxide and nitric oxide (NO$\cdot)$ in the phagolysosome, may also be toxic by the same mechanism as O$\sb2{-}.$ Our in vivo results indicated that peroxynitrite has the same intracellular targets as superoxide. Of …
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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
The ability of vascular cells to withstand oxidative insults is critical to vascular health. NAD+, which drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines …
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Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
… is methylated, which increases the likelihood of oxidative damage to the adjacent guanine. 8oxoG, in the presence of peroxynitrite, can form guanidinohydantoin or spiroiminodihydantoin and mispair with guanine, explaining C:G>G:C mutations. We show that uterine tissue is persistently exposed to …
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Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.
<p>Dietary flavonoids are ubiquitous and are marketed as supplements. Characterized as antioxidants, they offer protection against a number of degenerative diseases. Flavonoid mechanics involve free radical scavenging, metal chelation, and substrate association. The skeletal structure of flavonoids …
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The development of new methods for the assessment of oxygen radical-mediated oxidative damage to biomolecules with special reference to lipids
… in intact inflammatory SF samples against oxidative damage arising from reactive oxygen radical species generated via gamma-radiolysis (5.00 kGy) in the presence of atmospheric oxygen.
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Investigating the molecular biology of aging and extended longevity: Proteomic and genomic analysis of mouse liver
… of the aging process including the role of oxidative stress and the genetic basis of longevity. Progressive accumulation of oxidative damage to macromolecules is thought to underlie the aging-associated decline in physiologic function characteristic of the senescent phenotype. Mitochondria …
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Analyzing Vitamin D3 Supplementation and Deficiency in the Spinal Cord of Transgenic G93A Mouse Model of Amyotrophic Lateral Sclerosis
… exhibited D3 toxicity, evidenced by increased oxidative damage and apoptosis and lower antioxidant capacity vs. AI. HiD males exhibited lower oxidative damage, inflammation, apoptosis and neuron damage vs. AI. DEF females exhibited higher inflammation and a compensatory increase in GPx1 vs. AI. …
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Biological effects of bioactive components and extracts derived from edible plants commonly used in human nutrition
… attention on their possibility to counteract oxidative damage and inflammation. After a preliminary study of in vitro antioxidant activity, regarding the modification eventually occurring after home freezing and cooking of edible vegetables, cultured mammalian cells were used as experimental …
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Investigação de parâmetros bioquímicos em dois modelos animais de depressão induzidos por desamparo aprendido e administração do lipopolissacarideo de E.Coli
… resilient. Helpless animals showed more oxidative damage in PFC and serum when compared to controls. No difference was seen between helpless and resilient groups, but there was a positive correlation between the oxidative damage on serum and PFC and helpless behavior. There was no …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… return. Klotho-deficient mice lungs have higher oxidative stress, higher antioxidant demand, and varying airspace size and distribution. Systemically, Klotho-deficient mice develop premature organ degeneration and have a shorter lifespan than wild-type (WT) mice. However, constitutive …
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Investigation and validation of mammalian telomeres as biomarkers for health and disease
… have emerged as promising biomarkers of aging, oxidative stress, and disease. However, accurately quantifying telomere length (TL) remains technically challenging, particularly in murine models whose telomeres are substantially longer and more heterogeneous than those of humans. This thesis …
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The missing dimension of cell membrane organization. Study on cubic membrane structure and function
… the cubic membranes are protected from the oxidative damage. Further studies on antioxidants activity and oxidative damage biomarkers in both starved amoeba (with cubic membrane organization) and fed amoeba (without cubic membrane organization) shows that total antioxidant system and the …
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Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
… through HPA-axis dysregulation, inflammation, oxidative stress, and autophagic impairment. Growing evidence suggests females may be disproportionately vulnerable to these effects, yet mechanistic insight is lacking. This study investigated these molecular mechanisms within female Wistar rat …
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… effects of prenatal CORT and temperature on oxidative damage, but not on metabolic function. Nonetheless, mitochondrial physiology was not linked to cognitive performance. Data shows that most cognitive abilities - decision-making, detection of visual stimuli, behavioural flexibility, and …
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… effects of prenatal CORT and temperature on oxidative damage, but not on metabolic function. Nonetheless, mitochondrial physiology was not linked to cognitive performance. Data shows that most cognitive abilities - decision-making, detection of visual stimuli, behavioural flexibility, and …
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Genotoxic effects of nano and bulk forms of aspirin and ibuprofen on blood samples from prostate cancer patients compared to those from healthy individuals: The protective effects of NSAIDs against oxidative damage, quantification of DNA repair capacity and major signal transduction pathways in lymphocytes from healthy individuals and prostate cancer patients
… forms a strategy to prevent and minimise the damage in human lymphocytes. Aspirin nano (ASP N) caused a significant decrease in deoxyribonucleic acid (DNA) damage compared to aspirin bulk (ASP B). Also, ibuprofen nano (IBU N) showed a significant reduction in DNA damage compared to ibuprofen …
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