Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"oxidative cyclization"”.
-
I. Syntheses and Structures of the First 10-Phosphorus-3 and 10-Arsenic-3 Species. Ii. Intramolecular Oxidative Cyclization Reactions of Trivalent Arsenic and Carbonyl Functions (Phosphorandiide, Arsorane)
I. The synthesis and solid state structure of {10-P-3} 5-Aza-2,8-dioxa-3,7-di-tert-butyl-1-phosphabicyclo{3.3.0}octa-3,6-diene (ADPO) is described. The compound exhibits a T-shaped molecular geometry about the phosphorus center and represents the first example of a tri-coordinate hypervalent …
-
Intramolecular Reactions of Trivalent Phosphorus and Carbonyl Functions
… with 2-ketophenols readily undergo head-to-tail oxidative cyclization to yield stable tricyclic phosphoranes in cases where the carbonyl function is an aldehyde, trifluoroacetophenone, or diaryl ketone. A methyl imine function may also participate in such a reaction. Oxidative cyclization does …
-
Application of Mn(III) Oxidative Cyclizations to Natural Product Synthesis
… review of manganese(III) acetate free radical oxidative cyclization chemistry and its application toward functionalizing nitrogen containing heterocycles. Exploration of a cyclopropane ring opening reaction using indoline, and subsequent manganese(III) cyclization chemistry will be presented as …
-
Stereospecific alkynylation at the more hindered carbon of trisubstituted epoxides and concise syntheses of bis-THF acetogenins and analogues
… modular approach and features a cobalt mediated oxidative cyclization reaction, an efficient synthesis of epoxy butenolide, and a highly diastereoselective alkylation of a bis-THF aldehyde. The efficiency of the new synthetic sequence allows quick assembly of the series of compounds and the study …
-
Synthesis of Dimeric Pyrrole-Imidazole Alkaloids
… synthetic challenges. A manganese(III)-mediated oxidative radical cyclization has been developed to construct the core skeleton of these pyrrole-imidazole dimers and its mechanism is investigated by the methods of computational chemistry. Ent-15-epi-5,11-dioxomassadine has been synthesized by …
-
Synthesis and utility of electronically diverse polycyclic aromatics
… pendant aromatic precursors: electrophilic and oxidative cyclizations. Chapters One and Two describe research directed towards expansion of electrophilic cyclizations that utilize alkyne functionality to construct aromatized systems. Strongly-acidic conditions provide transient cationic …
-
Intramolecular Anodic Olefin Coupling Reactions: Synthesis Of Nitrogen- And Oxygen-Heterocycles
… dithioacetal. The key to the success of the oxidative cyclization reaction is the use of lithium methoxide as a base instead of the commonly used weak base, 2,6-lutidine. The synthesis demonstrates that a vinyl substituted ketene dithioacetal is compatible with anodic cyclizations and that it …
-
Synthesis of Aryl Ynol Ethers and Their Synthetic Applications
… could undergo a retro-4π/6π electrocyclization reaction to afford naphthlenes. Finally, we utilized this novel electrocyclization in the synthesis of dictyodendrins F, H, and I. In particularly, we used the hetero-[2+2]-cycloaddition reaction between aryl ynol ethers to form …
-
Studies into the Biosynthesis and Chemical Synthesis of Indolocarbazoles and Related Heterocyclic Compounds. Metalation of Indole-6-Carboxamide.
… of the indole group allows for a wide range of oxidative and substitution reactions, creating a versatile platform for generating structurally diverse molecules. This thesis explores enzyme and synthetic chemistries that act upon indoles and related molecules. Chapter 1 describes the results of …
-
The study of the asymmetric synthesis of lignans
… alkylation reactions, and intramolecular oxidative coupling reactions. In addition to developing asymmetric synthetic methodologies for chiral lignans, an investigation of chirality in arylnaphthalene lignans which lack stereogenic centers has also been carried out. In the first project, a …
-
Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP)
… including a peptide coupling reaction and oxidative cyclization, was performed. Investigation into completing the synthesis of kapakahine C is ongoing.</p> <p>The inhibition of the SH2-containing inositol 5’-phosphatase (SHIP) can modulate the dephosphorylation of phosphoinositols. These …
-
Synthese neuer Furo[3,2-a]- und Pyrano[3,2-a]carbazolalkaloide
… wurde eine Sequenz aus oxidativer Cyclisierung verschiedener Diarylamine verwendet. Über diese Strategie konnten drei verschiedene Furo[3,2-a]carbazole dargestellt werden und aufgrund eines Vergleichs der analytischen Daten eine fehlerhafte Strukturzuweisung bei der …
-
Design, synthesis, and characterization of porphyrin derivatives for biological applications
Chapter 1 of this Dissertation presents a brief introduction to the basic properties of porphyrins and their derivatives (hydroporphyrins), their abundance and functions in the nature, and their applications in photodynamic therapy. Chapter 2 reports the synthesis, characterization, conformational …