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Showing 1 to 20 of 32 for “"oxidative cleavage"”.
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Nitrate Radical-Mediated Oxidative Cleavage of Olefins Using TiO2 Photocatalysis
… numerous chemical transformations. Among these, oxidative cleavage has emerged as a critical process, enabling the conversion of olefins into high-value carbonyl compounds such as aldehydes and ketones. These compounds play an essential role in synthesizing polyamides, polyurethanes, and various …
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An investigation of the oxidative cleavage of the double bond
… was undertaken to find a method for the oxidative cleavage of the double bond, using oleic acid. The primary purpose of this investigation was to find a cheap method of splitting the double bond in oleic acid and obtaining the saturated fatty acids formed therefrom. The procedure used in …
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Synthesis and characterization of rhenium (vii) and rhuthenium (ii) dendritic catalysts: oxidative cleavage and epoxidation of alkenes
Herein we report the successful synthesis of a class of stable and flexible Schiff-base chelators capable of coordinating both ruthenium (II) and rhenium (VII) and which would be catalytically active for oxo-transfer reactions. The synthesis of bidentate (L1), tetradentate (L2-L3), and multidendate …
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Osmium Catalyzed Dihydroxylation And Oxidative Cleavage Of Vinyl Sulfone And Elucidation Of The Vinylsulfone Polypropionate Methodology For The Synthesis Of The C32 Des-Methyl C28-C34 Actin Binding Tail Of Aplyronine A
… natural products such as aplyronine A. Final oxidative cleavage via ozonolysis has been shown to be difficult providing variable yields. Furthermore, elegant synthesis of the C28-C34 segment of the aplyronine A actin binding tail has proved elusive. Utilization of OsO4 and catalytic citric …
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Gas Phase Oxidation of Levulinic Acid for the Production of Maleic Anhydride over Supported Vanadium Oxide Catalysts
… suggest that maleic anhydride forms by the oxidative cleavage of the methyl carbon in α- and β-angelica lactones, which form as primary products by facile dehydration of LA. We have identified all major and minor/side products, and we propose plausible mechanisms leading to their formation. …
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Improved Synthesis, Separation, Transition Metal Coordination and Reaction Chemistry of a New Binucleating Tetraphosphine Ligand
… involves discussion of alkene hydration and oxidative cleavage reactions catalyzed by late transition metal complexes. Previously reported results are summarized here. Mechanistic aspects of alkene hydration catalyzed by late transition metal complexes are also explained. The second part of …
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Investigations into alkene hydration and alkene oxidation catalysis
… shown that the aldehyde is produced from the oxidative cleavage of the double bond of an alkene. The oxidative cleavage is a non-catalytic reaction and all attempts to produce a catalytic reaction have failed. The evidence collected suggests the oxidative cleavage is coupled with phosphine …
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Studies in ring D fragmentation of estrone
… for 14-allylation. The approaches were based on cleavage of the 16,17-bond via oxidative cleavage or fragmentation methodology. The oxidative cleavage routes involved the preparation of 3-methoxy-17 –methylestra-1,3,5(10), 16-tetraen-15-one, which was shown not to undergo regioselective …
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Enantioselective synthesis of 2,2,5-Tri- and 2,2,5,5-tetrasubstituted tetrahydrofurans and synthesis of diketopiperazine containing natural products
… via ring-opening metathesis/cross-metathesis or oxidative cleavage and refunctionalization. A partial synthesis of the bioactive diketopiperazine containing natural product gliocladin C was achieved in nine steps, and 13.4% overall yield. The synthesis featured several novel transformations …
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I Ceric ammonium nitrate-mediated oxidative cleavages of hemiacetals II Synthesis of beta-proline derivatives through the tandem chain extension-imine capture reaction
<p>A novel ceric ammonium nitrate-mediated oxidative cleavage of hemiacetals generated through the use of the zinc carbenoid-mediated tandem chain extension-aldol reaction was developed. This chemistry has been applied towards the formation of a class of natural products, phaseolinic acids, in two …
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Studies toward a total synthesis of (±)-subergorgic acid
… deoxygenation of the keto function in 99 and oxidative cleavage of the double bond provided the ketone 103. The ketone 103 was converted into dienedione 98 via a four step sequence, involving Saegusa oxidation to give 156, deketalization of the ketal function and benzeneseleninic acid …
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Synthesis and selective reactivity of 14β-formyl 19-norsteroids
… synthetic sequence to key intermediates for oxidative cleavage to 14(3-formyl 19-norsteroids was undertaken. cis-Dihydroxylation of the dihydrocycloadduct gave an isomeric mixture of the 15a,16a- and 15β3,16β3-diols, which were protected via acetonide formation. Sequential reduction of the …
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INVESTIGATIONS OF HYPERVALENT IODINE COMPOUNDS IN ORGANIC TRANSFORMATIONS
… proposed. Chapter 4 details our research on the oxidative cleavage of C=C with PIFA/water. In the presence of a small amount of water in acetonitrile at 65-70 oC, [bis(trifluoroacetoxy)iodo]benzene (PIFA, 26) converts styrenes into benzaldehydes in good to high yields. Contrary to literature …
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Strategies towards the synthesis of prostaglandin analogues
… to perform cis-hydroxylation followed by oxidative cleavage of the cyclohexene moiety have been successfully implemented. Finally, a synthesis was designed for generating oxygen analogues of the prostaglandin targets.
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Total synthesis of ent-plagiochianin B and development of a metathesis approach to aleutianamine.
… subsequent discovery of a palladium catalyzed oxidative cleavage of a terminal olefin. The strained and heavily bridged pyrroloiminoquinone alkaloid aleutianamine was isolated in 2019 from the North Pacific sponge Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 and exhibits …
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Construction and Calibration of a Laboratory Ozonizer
… as the most general and reliable procedure for oxidative cleavage with simultaneous location of the double bond. The inorganic chemist has studied the action of ozone on various solvents (14) and on alkali metals, ammonia, and substituted ammonias (15). The biological chemist has employed ozone …
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Synthesis and structure activity relationships of ring D modified steroidal hormones
… Established ring D cycloaddition and oxidative cleavage methodology gave ring D 14α-formyl and 14α, 17α-diformyl compounds as key intermediates in the overall synthetic plan. Chemoselective- and stereoselective nucleophilic addition at C-14¹ of the …
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Regulation of the GCV3 gene in Saccharomyces cerevisiae
The glycine cleavage system (GCS) is a multienzyme complex containing four proteins. The GCS, which is important for the growth and viability of organisms ranging from bacteria to humans, catalyses the oxidative cleavage of glycine into CO 2 and NH 3 . Concomitantly it generates the C1-donor …
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