Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"oxidative DNA damage"”.
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In Vivo Analysis of the Process of Oxidative DNA Damage of Escherichia Coli
… we conclude that the vulnerability of cells to oxidative DNA damage is strongly determined by their ability to control free iron and cysteine and to scavenge H2O2.
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… the effects of long-term strenuous exercise on oxidative DNA damage and proteinuria in trained individuals. In the first project, four successive triathlons accompanied by long-term training in a triathlete was chosen as the experimental design and procedure. In the second project, repeated 5-h …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… the effects of long-term strenuous exercise on oxidative DNA damage and proteinuria in trained individuals. In the first project, four successive triathlons accompanied by long-term training in a triathlete was chosen as the experimental design and procedure. In the second project, repeated 5-h …
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Thymoquinone decreases oxidative DNA damage (8-OHdG) in DMBA treated female Sprague Dawley rats
… assayed fingerprint of free radical attack on DNA and is involved in tumor progression. Five groups of 10 rats (Controls, DMBA, TAM, TQ, and TAM+TQ) were treated for 10 weeks after injection of DMBA. Tumors were found in only two DMBA treated rats. However, there was a coloration observed in …
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Consequences of Oxidative DNA Damage: Base-Pair Dissociation, Singlet Oxygenation and DNA-Protein Crosslinking
<p>8-Oxo-2′-deoxyguanosine (OG) is a common DNA lesion resulting from oxidatively generated damage and pairs with complementary cytidine (C) in Watson Crick base-pairing within duplex DNA. The WC-OG·C lesion, if not recognized or repaired, not only leads to G⋅C→T⋅A transversion mutations (through …
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Oxidative DNA damage : mutagenic properties of 5-hydorxycytosine, 5-hydroxyuracil and uracil glycol in Eschericia coli
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1998.
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HYDROGEN PEROXIDE-INDUCED CYTOTOXICITY AND OXIDATIVE DNA DAMAGE ON HUMAN EMBRYONIC STEM CELLS AND THEIR DIFFERENTIATED FIBROBLAST-LIKE PROGENIES
… To date, wide use of hESCs in cytotoxicity and DNA damage study has been restricted by technical limitations. One such limitation is from MEF feeder cells. Although MEF help maintain cultured hESCs in there undifferentiated status, they nevertheless become a form of contamination when pure …
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The Mechanism of Copper Toxicity in Escherichia Coli
… copper-toxified cells had elevated levels of DNA damage and oxidative stress. Therefore, the mechanism of copper toxicity was hypothesized to be mediated by oxidative DNA damage through a Fenton-like reaction. In contrast to this hypothesis, copper-stressed Escherichia coli sustained less …
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An investigation into the mechanism of toxicity of zinc oxide nanoparticles.
… of NP dissolution. ZnO NPs also induced oxidative DNA damage as evidenced by an increase in the Fpg sensitive sites. The reactive oxygen species triggered a decrease in mitochondrial membrane potential and an increase in the ratio of Bax/Bcl2 leading to apoptosis through the intrinsic …
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The Mechanism of Oxygen and Nitric Oxide Toxicity in Escherichia Coli
… that NO/H2O2 killed cells by damaging their DNA through the Fenton reaction. NO also blocked respiration, an event which previous studies have shown can stimulate oxidative DNA damage. The resultant accumulation of NADH accelerates the reduction of free flavins by flavin reductase, and these …
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Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… seen commonly in aging. Aging further increase oxidative stress in the kidney and are associated with reduced renal function. Aging is progressive accumulation of oxidative agents. Advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) formation has been implicated …
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STUDY OF EPIGENETIC REGULATORS AND SIGNATURES OF AGING
… the level of protein aggregation, reactive oxidative species, DNA damage and systemic inflammation in the brains of NELF-A depleted flies. This protection is conserved in human cells where NELF-A depletion confers improved resistance against oxidative stress. Reduced oxidative DNA damage …
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Identification of the Phosphatase NUDT5 as a Target for the Treatment of Triple Negative Breast Cancer
… (TNBC) cells. The effect of decreased NUDT5 on DNA was investigated by measuring oxidative DNA lesions, replication fork progression, and DNA damage response. To investigate the potential clinical applicability of the NUDT5 inhibitor for future clinical studies, in vitro doseresponse assays were …
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More evidence for H2O2-mediated oxidative stress in vitiligo-increased epidermal DNA damage / repair.
… is a plethora of evidence for H2O2-mediated oxidative stress in the epidermis as well as in the system in patients with vitiligo (for review see (Schallreuter, Bahadoran et al. 2008). Xanthine dehydrogenase / xanthine oxidase (XDH / XO) catalyses the oxidative hydroxylation of hypoxanthine to …
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Antioxidents or reduced oxygen tension as a defense system in T cells ex vivo and in vitro
… from the group of Barnett, suggested that oxidative stress may play a role in the immunosenescence process, through resultant genomic instability, cell cycle delay and arrest. The aim of this research programme was to investigate the effect of the antioxidants, ebselen, NAcetyl L- Cysteine …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… nitrogen species (RNS) production and oxidative DNA damage in the MPTP-treated substantia nigra. Additional immunohistochemical staining also showed that MPTP induced glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in the substantia nigra (SN). …
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Development of an analytical method to quantify the oxidative deoxyribose damage product 3'-phosphoglycolaldehyde induced by radiation, iron and peroxynitrite
Deoxyribose oxidation in DNA forms strongly electrophilic terminal blocking groups and abasic sites capable of stopping polymerases, forming DNA-protein crosslinks and nucleobase adducts. These threats to the genetic integrity of cells are caused by exogenous and endogenous oxidizing agents and may …
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p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
… machinery of the cell. Chapter 3 summarizes cDNA microarray experiments in which Trp53-/- and Trp53+/+ fibroblasts were treated with a panel of genotoxic agents, and assayed for p53-dependent upregulation or downregulation of the approximately 15,000 gene sequences represented on the …
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