Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"oxazole"”.
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Strategies for thiazole/oxazole-modified microcin discovery
… growing family of natural products, the thiazole/oxazole-modified microcins (TOMMs), and discuss novel methods used to correlate the gene clusters to natural products from this family of metabolites. In chapter 2, I establish the sequence diversity and structural capability of bacteria and archaea …
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A genomics-led approach to deciphering heterocyclic natural product biosynthesis
… and are widespread among natural products. Oxazole-containing natural products possess a broad range of bioactivities and are of great interest in the pharmaceutical and agrochemical industries. Herein, the biosynthetic routes to the oxazole-containing phthoxazolins and the bis(benzoxaozle) …
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On the biosynthesis and discovery of ribosomally synthesized and post-translationally modified peptides
Thiazole/oxazole-modified microcins (TOMMs) comprise a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) that all contain thiazole and oxazole heterocycles derived from cysteine, serine, and threonine residues, respectively. The thiazole/oxazole heterocycle is …
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Single molecule studies of molecular electronics and biohybrid materials
… transport is investigated. Here, we show that oxazole serves as an efficient anchor group to form stable gold-molecule-gold junctions. Molecular charge transport is studied using conjugated oligomers with oxazole anchors, focusing on the role of the heteroatom substitution position in terminal …
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Understanding the singlet oxygen reactivity of salarin C through synthesis of a simplified macrocyclic analogue; multicomponent, enantioselective organocatalytic synthesis of tetrahydropyridazinones.
… interest is the marked reactivity of its oxazole moiety with singlet oxygen that converts salarin C to its biologically inactive congener, salarin A. While this photocatalyzed rearrangement, i.e., Wasserman rearrangement, is known typically requiring UV irradiation and a photosensitizer to …
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ΣΥΝΘΕΣΗ ΚΑΙ ΜΕΛΕΤΗ 0-ΚΙΝΟΝΙΜΙΝΟ-, 0-ΚΙΝΟΝΟ-ΜΕΘΙΔΟ- ΚΑΙ Ο-ΚΙΝΟΝΙΜΙΝΟ- ΜΕΘΙΔΟ- ΠΑΡΑΓΩΓΩΝ ΤΗΣ 9, 10-ΦΑΙΝΑΝΘΡΕΝΟΚΙΝΟΝΗΣ ΚΑΙ ΤΗΣ 1, 2-ΑΚΕΝΑΦΘΕΝΟΚΙΝΟΝΗΣ
… AROMATIC COMPOUNDS LEAD TO THE FORMATION OF OXAZOLE- DERIVATIVES. 1,2-ACENAPHTHENEQUINONE-MONOXIME ALSO REACTS WITH STABLE AND SEMI-STABLE YLIDES AND THE RESPECTIVE O-QUINONE- METHIDE IMINES ARE FORMED. SEVERAL O-QUINONE-METHIDES OF 1,2- ACENAPHTHENEQUINONE REACT WITH NITROGEN COMPOUNDS TO …
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Total synthesis of (-)-tantazole B. Total synthesis of (+,-)-FR900482
… applied to the synthesis of the other members of oxazole/thiazoline family.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI) The first and, to date, only total synthesis of $(\pm)$-FR900482 is also described here. The stereocontrolled total synthesis of FR900482 features a facile construction …
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Stereochemical aspects of virginiamycin biosynthesis: biosynthesis of antibiotic A33853
… stereochemical control in the formation of the oxazole moiety. This information allowed for postulation of a ring closure pathway. Stereochemical investigations were also carried out on the dehydroproline unit and it was shown that both (R) and (S) prolines were incorporated into the …
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Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis
… It contains two patches of thiazole and (methyl)oxazole/methloxazoline rings that endow its rigidity. It has an Nα, Nα-dimethyl-arginine at the N-terminus, which is critical for the antibacterial activity. The N-methyltransferase responsible for this modification in the gene cluster is very …
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Synthesis and characterization of high performance polybenzoxazoles
… weight poly(hydroxy amide)s and polybenzoxazoles possessing a variety of backbone compositions have been synthesized via low temperature polycondensation and a novel catalytic cyclization reaction. Preliminary experiments involved the synthesis of poly(hydroxy amide)s and polybenzoxazoles …
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Development of new fluorescence spectroscopy approaches for the study of silica
… 2dimethylaminoethylaminocarbamoyl)methoxy)phenyl) oxazole), has unique silica specific fluorescence and is used in biology to understand biosilicification. This ‘silicaphilic’ fluorescence is not well understood nor is the response to local environmental variables like solvent and pH. We …
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Excited state intramolecular proton transfer (ESIPT) to nitrogen in heterocyclic compounds
… azole group includes the 2-(2'-hydroxyphenyl)-oxazole (HPO) and -thiazole (HPT) whose study complements their well known benzo counterparts (HPBT and HPBO) and the related imidazoles. - The compounds of the pyridine group are related to the basic structure of 2-(2'-hydroxyphenyl)-pyridine …
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Revealing the molecular details of azoline formation in ribosomal natural product biosynthesis
The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large chemical and functional space and are linked by the presence of the …
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New Pre-Catalysts for Olefin Polymerisation and Ring-Opening Polymerisation of Lactides/Lactones
… two solvates of compound 27. Imidazole (L20H), oxazole (L21H), α-diimine (L22), iminopyridine (L23, L24) and phenoxyimine (L25H – L29H) ligand sets have been treated with group 5 (Nb or Ta) chlorides or oxytrichlorides to afford compounds 28 – 50, which have been fully characterised. The …
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Studies Towards the Total Synthesis of the Chivosazoles
… into an aldehyde and the oxazoline into an oxazole, followed by a Stork-Zhao olefination transforming the aldehyde to a Z-vinyl iodide for a macro-Stille coupling reaction, which achieved the ring closure to afford macrocycle E. Chapter 3 discusses the developments towards the synthesis of …
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Single electron studies of acylammonium intermediates, zinc-mediated carboxylations in flow, and the total synthesis of (–)-inthomycin C.
… well as our unpublished total synthesis of the oxazole triene natural product, inthomycin C, a feat achieved during our group's on-going studies towards the bioactive peptide-polyketide natural products: oxazolomycin B and curromycin A.
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Structure and function analysis of the natural product plantazolicin, a bacillus anthracis-specific antibiotic
… modified to contain thiazoles and (methyl)oxazoles. This group of compounds, known as thiazole/oxazole-modified microcins (TOMMs), exhibit disparate biological activities and complex chemical structures. Using high-resolution mass spectrometry, chemoselective modification, genetic …
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Beiträge zur Chemie von Übergangsmetallkomplexen mit Alkenylcarbenen, Phosphoryliden und bioaktiven Hydroxyverbindungen als Liganden
… anderem Combretastatin-analoge Chalkone und Oxazole. Unter wasserfreien Bedingungen konnten auch die Ferrocenylchalkone dargestellt werden. Durch Reaktion von Dimethyltitanocen mit dem sterisch anspruchsvollen Naturstoff Schisandrol A wurde ein stabiler Methyl-Titanocen-Schisandrol A-Komplex …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ANTIPARASITIC AND ANTICANCER AGENTS
… scaffolds linked to a 3-bromo-4,5-dihydroisoxazole (BDHI) core. Structure-activity relationship (SAR) exploration guided the synthesis of novel derivatives, incorporating modifications to enhance potency, drug-like properties, and blood-brain barrier permeability. Our investigations revealed …
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Total Synthesis of CPI-2081, Breitfussin B and Synthetic Studies Towards Myriastramide C and Goadsporin
… acids, six of which are cyclised to form four oxazole and two thiazole rings. Goadsporin was found to be active specially in streptomycetes, with the ability to promote morphogenesis and secondary metabolism. It can also promote antibiotic production. The synthesis of this natural product was …
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