Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"oxaliplatin"”.
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Dose-banding studies on oxaliplatin
Oxaliplatin is an anticancer drug widely used in cancer chemotherapy. This thesis evaluates whether a specific dose-banding scheme for oxaliplatin could replace the individual dosing method that is currently used in the oxaliplatin administration. Dose-banding was introduced into UK clinical …
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Multidrug resistance-associated protein 2 (MRP2) and oxaliplatin transport
The platinum-based drug oxaliplatin is currently used in the clinical treatment of gastrointestinal cancer. Efflux membrane transporters have been reported to play roles in determining the cellular accumulation and activity of platinum-based drugs, but there have been few studies of oxaliplatin. We …
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HPLC analysis to assess efficacy of cisplatin, nedaplatin, and oxaliplatin
… assess the binding of cisplatin, nedaplatin, and oxaliplatin to the dinucleotide dGpdG. By examining the concentration ratios and incubation periods at 37 °C, we measured the amount of platinum drug reacted with DNA (platination rates) indicating the percentage of Platinum-DNA (Pt-DNA) adducts. …
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Pharmacological determinants of oxaliplatin neurotoxicity in patients undergoing cancer chemotherapy
Oxaliplatin-based chemotherapy has become the standard treatment for gastrointestinal cancers. Oxaliplatin-induced neurotoxicity often compromises treatment delivery and causes long-lasting neurological deficits that negatively impact upon patient's quality of life. Calcium and magnesium (Ca/Mg) …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
Oxaliplatin is a platinum anticancer drug approved for medical use in treating gastrointestinal cancers. Organic cation transporters (OCTs) may contribute to the tissue accumulation and unwanted toxicities of oxaliplatin. The overall aim of this thesis was to develop new bioanalytical methodologies …
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Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
… the treatment of advanced stage CRC employs an oxaliplatin-based chemotherapy regimen, which has shown a response rate of 50 – 60%. Nevertheless, the majority of CRC patients experience relapse after surgery and develop resistance to oxaliplatin thereby limiting its efficacy and usage at …
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Practice Patterns and Health Outcomes of Adjuvant Oxaliplatin Chemotherapy for Colorectal Cancer
INTRODUCTION: Oxaliplatin-containing adjuvant chemotherapy improves survival for stage III colon cancer. Yet it is not without harms, most commonly dose-dependent peripheral neuropathy. The 2018 International Duration Evaluation of Adjuvant Chemotherapy (IDEA) trial sought to determine the optimal …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
Oxaliplatin is a platinum-based anticancer agent used for the treatment of colorectal cancer. Oxaliplatin chemotherapy is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests …
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Tailored chemotherapy based on genomic polymorphisms for metastatic colorectal cancer treated with 5-fluorouracil plus oxaliplatin or irinotecan in Korean patients
배경: 옥살리플라틴과 이리노테칸은 전이성 대장암 환자에서 5-FU와 함께 투여하여 FOLFOX 또는 FOLFIRI용법으로 일차치료로서 가장 많이 사용되는 항암제이다. 본 연구의 목적은 전이성 대장암 환자에서 전향적 연구로서 항암제와 연관된 유전자 다형성을 분석하고 환자에 맞는 약제를 선택하여 일차치료를 진행하여 이에 대한 반응도를 알아보기로 하였다. 방법: 50명의 전이성 대장암 환자에서 말초혈액을 통해 유전자 다형성을 분석하였다. PCR-based RFLP 방법을 사용하여 TS, MTHFR-977, XPD-751, …
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Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
… anticancer drugs cisplatin, carboplatin, and oxaliplatin form similar adducts on DNA, only oxaliplatin is active in colorectal cancer. Human organic cation transporters hOCT1 and hOCT2 markedly increase oxaliplatin, but not cisplatin or carboplatin, accumulation and potency in cells. These …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
… cisplatin and its analogues, carboplatin and oxaliplatin, were evaluated. Previously all platinum anti-cancer agents were assumed to kill cells via DNA cross-linking. However, using an RNAi-based drug mechanism of action predictive signature, we were able to determine that oxaliplatin instead …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… investigated using the chemotherapeutic agent oxaliplatin, which induces a sensory neuropathy in patients. Following infusion of the drug, patients experience abnormal skin sensations (paresthesias), which are triggered or aggravated by exposures to cold. The receptive properties of afferents …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… anticancer platinum drugs such as cisplatin, oxaliplatin and carboplatin. The clinical efficacy of cisplatin, oxaliplatin and carboplatin is limited due to acquired resistance and dose limiting side effects. The three major pharmacological factors contributing to the intrinsic cytotoxicity of, …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… sympathetic neurons. The chemotherapeutic drug oxaliplatin induces an acute cold hypersensitivity in patients, and has been suggested to act on voltage-gated sodium channels. The activation of sodium channels alone did not alter cold sensitivity in sensory neurons, however the application of …
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Vergleich von Mikronukleus- und Chromosomenaberrationstechnik bei der Dokumentation zytogenetischer Schäden in neoadjuvant radio-chemotherapierten Rektumkarzinompatienten
… RT-Woche, 1000mg/m2/d) oder in Arm B mit 5-FU + Oxaliplatin (5-FU d 1-14 + d 22-35, 250mg/m2/d; Oxaliplatin d1,8,22,29, 50mg/m2/d) zusätzlich zur Bestrahlung mit 50,4Gy (1,8Gy/d) behandelt. 15 Patienten unseres Kollektivs wurden dabei in Arm A, 9 Patienten in Arm B randomisiert. Zur Darstellung …
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Developments in the chemistry and nanodelivery of platinum anticancer agents
… platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of cancer. A number of side effects accompany platinum-based therapy and novel approaches are under investigation to attenuate these negative effects and …
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… therapeutic efficacy of MG in a mouse model of oxaliplatin-induced mechanical hypersensitivity using pharmacological inhibition. 2. Contributions of cannabinoid signaling to the therapeutic efficacy of MG in a mouse model of oxaliplatin-induced mechanical hypersensitivity and inflammatory pain …
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The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives
… have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This …
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Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes
… drugs such as cisplatin, carboplatin and oxaliplatin are used in treatment. Cisplatin enters the cell through copper transporter CTR1 by passive diffusion and bind to DNA and proteins. Cisplatin is found to inhibit several enzymes targeting cysteine, histidine and methionine residues, …
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