Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"oxLDL"”.
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Inhibition of Macrophage Binding and Uptake of OxLDL by OxLDL-Specific Human Monoclonal Antibodies
"목적 : 동맥경화증은 대표적인 관상동맥 심질환중의 하나이다. 동맥경화증은 동맥의 혈관 벽에 콜레스테롤이 축적되고, 여러 면역반응이 관찰되는 염증반응이다. 최근 여러 가지 자가 면역 인자들이 동맥경화증의 개시와 진행에서 중요한 역할을 하는 것으로 밝혀졌다. 산화 저밀도 지질단백질은 이러한 염증반응을 유발하고 지속시키는 주요 자가 항원 중의 하나로 알려져 있다. 본 연구의 목적은 소속연구실에서 동맥경화 환자의 말초 혈핵 단핵세포(peripheral blood mononuclear cells)에서 분리하여 산화 저밀도 지질단백질에 …
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Die Angiotensin II induzierte Vasokonstriktion isolierter Arterien und deren Beeinflussung durch OxLDL
… II induzierte Vasokonstriktion untersucht. OxLDL steigerte die durch eine Schwellenkonzentration von Angiotensin II hervorgerufene Kontraktion isolierter Kaninchenaortenringe um das 2,9 fache, während es den Basaltonus unkontrahierter Gefäße nicht beeinflusste. Dabei war zunächst unklar, …
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An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function
… activation by oxidised Low-Density Lipoproteins (oxLDL), which drives both atherogenesis and thrombosis. However, the mechanism by which oxLDL drives plateletactivation and thrombosis is unclear.The combinations of matrix protein within the vascular wall and within the thrombus, especially if …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… and oxidized low density lipoprotein (oxLDL) 2 1. Gangliosides 2 2. OxLDL 3 C. Inflammatory signaling pathways 7 1. JAK-STAT pathway 7 2. Lipopolysaccharide (LPS) –induced signaling pathways 8 3. Liver X receptor (LXR) pathway as anti-inflammatory signaling Pathway 9 D. Aims of study 10 …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… of atherosclerosis and the oxidized LDL (oxLDL) may represent a target for autoantibodies involved in the pathogenesis of the disease. The aim of this study was; first, analysis of the Ag-binding characteristics of anti-oxLDL autoantibodies isolated from atherosclerosis patients' PBMC; …
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The influence of oxidised low density lipoproteins on platelet activation
… platelet activation by oxidised LDL (oxLDL). OxLDL but not native LDL (nLDL) induced a modest degree of aggregation, which was ADP dependent. However, oxLDL was able to induce shape change, one of the earliest stages of platelet activation, independently of secondary agonists. Platelet …
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Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies
… response of RPE due to oxidized lipoproteins (oxLDL) treatments. A crucial aspect in proteomics studies is the design of bioanalytical strategies that maximize coverage of the complex repertoire of a proteome. A comprehensive, unbiased examination of the proteome represents a powerful approach …
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Studies of CD36 interacting with fatty acids, oxidized low-density lipoprotein, and the cellular plasma membrane
… CD36 binds oxidized low density lipoprotein (oxLDL), which promotes atherosclerosis, and fatty acids (FA), which promotes their cellular uptake. To gain insights into the molecular mechanisms of uptake, HEK293 cells expressing CD36 were studied by cell biological and fluorescence methods. To …
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The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
… uptake of oxidized low-density lipoprotein (oxLDL). Thus, an analysis of the signaling pathway of apoptotic induction by oxLDL is of value in understanding the development of atherosclerotic plaque. In order to elucidate the signaling pathway of apoptosis induced by oxLDL, we have used …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
<p>Oxidized low-density lipoproteins (OxLDL) mediate many of the pathological events associated with atherosclerosis. Oxysterols, the major cytotoxic component of OxLDL, induce apoptosis in macrophages by a calcium flux mediated activation of cytosolic phospholipase A<sub>2</sub> resulting in the …
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Proliferationsverhalten kultivierter Mesangialzellen und glatter Gefäßmuskelzellen nach Stimulation mit Angiotensin II und atherogenen Lipoproteinen : Rezeptorbeteiligung
… Low Density Lipoproteinen (natLDL bzw. oxLDL) auf den Zellzyklus von kultivierten vaskulären Gefäßmuskelzellen (BSMC) und Me-sangiumzellen (NHMC) im Sinne einer Proliferationsänderung unter anderem durch eine Beeinflussung der beteiligten Rezeptoren. Ebenso wurde die Interaktion von …
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Proatherosklerotische Wechselwirkung von oxidativem Stress, Low-Density-Lipoprotein, Angiotensin II und Endothelin-1 in humanen Endothelzellen
… an Rezeptoren für die Aufnahme von nLDL und oxLDL. Abschließend wurden Signalwege untersucht, die durch nLDL und oxLDL aktiviert werden. Tierexperimentielle Untersuchungen in Aorten und Herzen fettreich gefütterter Wildtyp- Mäuse unterstützen die Zellkultur-Ergebnisse einer Induzierung des …
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Vergleichende methodische Untersuchungen zur Sauerstoffradikalbildung vaskulärer Zellen durch Angiotensin II und Lipoproteine
… sich. Angiotensin II und oxidiertes LDL (oxLDL)induzieren eine verstärkte Bildung von O2- in vaskulären Zellen. Die vorliegende Arbeit beschäftigte sich in vergleichenden Untersuchungen mit der Detektion möglicher O2--Bildung durch arterielle Gefäßringe, glatte Muskelzellen, …
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The effect of free fatty acids on endothelial cells
… components of oxidized low density lipoprotein (OxLDL) molecules e.g. oxidized polyunsaturated fatty acids (PUFAs), or saturated free fatty acids (FFA) are alone sufficient to decrease endothelial cells. This hypothesis was tested by incubating porcine aortic endothelial cells (PAECs) with …
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Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… with oxidized low-density lipoprotein (oxLDL) or free cholesterol induces a low-grade inflammatory phenotype, characterized by elevated expression of CD49d, CD86, CD74, and CD38, but these features were not observed during the acute phase. The low-grade inflammation is marked by enhanced …
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SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING
… which recognize and engulf oxidized-LDL (oxLDL) to form foam cells. Knowing that certain antibodies directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin (CL) show opsonizing cross-reactivity with oxLDL it can be proposed that there is a link between immune …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… lipid, oxidised low-density lipoprotein (OxLDL), dose dependently decreased basal and maximal respiration and fat-feeding of apolipoprotein E deficient (ApoE-/-) mice reduced mitochondrial DNA copy number relative to nuclear DNA in aortas. Mitochondrial respiration of ApoE-/- mouse aortas, …
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Pathogenesis of experimental tuberculosis in guinea pigs
… tuberculosis. Oxidized low density lipoproteins (OxLDL), known to be rich in cholesterol, accumulated in macrophages during infection and elevation of OxLDL levels was accompanied by increased expression of the OxLDL scavenger receptors CD36 and LOX-1. The significance of these data are that …
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IL-25 and B cells in atherosclerosis
… (PC), a major epitope on oxidized LDL (oxLDL) via innate lymphoid cell type 2 (ILC2)-derived IL-5. We suggest that the essential trigger for this mechanism is the expansion of ILC2s. Additionally, blockade of endogenous IL-25 at the onset of atherosclerosis led to increased plaque …
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