Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"overt diabetes"”.
-
Development and Evaluation of Protocol for Early Screening For Diabetes in Pregnancy: A Quality Improvement Initiative
Diabetes Mellitus is a dangerous condition known to cause adverse effects to both mother and fetus. Rates of diabetes are increasing worldwide. Research indicates that undiagnosed pre-existing, or overt, diabetes may increase poor outcomes in pregnancy; therefore, new recommendations from …
-
Molecular Approaches to the Genetics of Obesity: Mapping and Characterization of the Murine Diabetes (db) Gene
… strains, and particularly mice. The murine diabetes, db, mutation is an autosomal recessive mutation located on mouse chromosome 4 which demonstrates a metabolic/behavioral phenotype similar to that observed in human obesity and Type II diabetes. Homozygous db animals manifest profound …
-
Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… these mice progressively succumb to severe diabetes. Mechanistic analysis revealed that spontaneous DNA damage accumulated in the pancreatic b-cells, a unique subset of endocrine cells solely responsible for insulin production to regulate glucose homeostasis. The genesis of adult b-cells …
-
Morbidity from antiretroviral metabolic effects in Africa: The Mama Study
… and risk factors associated with new onset diabetes mellitus in the HIV-infected population. Furthermore, efavirenz is the preferred nonnucleoside reverse transcriptase inhibitor (NNRTI) in first-line antiretroviral therapy (ART) regimens in low- and middle-income countries, where the …
-
Metabolic regulation of human vascular endothelial cell function in vitro
… of disorders, including insulin resistance, diabetes and atherosclerosis, leading to dysregulated vasodilation as well as increased monocyte adhesion and plaque formation (atherosclerosis). The underlying molecular mechanisms leading to endothelial dysfunction are still in question. The work …
-
Molecular analysis of innate immunity in type 1 diabetes
Introduction: Type I diabetes (T1D) is an autoimmune disease of children and young adults that selectively destroys the insulin-producing islet cells in the pancreas. NOD mice, the best validated animal model of T1D, manifests islet infiltration as early as 4 weeks, leading to β-cell destruction …