Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"overstimulation"”.
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified proline-rich tyrosine kinase 2 (Pyk2) as an mGluRl/5 interacting protein, …
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„Orchidėjos gali žydėti ir pievose?“: Itin didelio jautrumo ryšys su suvokiama socialine parama ir klestėjimu tarp jaunų suaugusiųjų akademiniame kontekste /
… with flourishing, while sensitivity to overstimulation (SOS) was negatively correlated. The AES component was also positively related to perceived social support. Perceived social support mediated only partly the relationship between AES and flourishing, but not the relationship between …
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Making Sense of Pre-Symbolic Trauma: A Qualitative Study on the Lived Experiences of Adults Who Were Born Extremely Prematurely
… ongoing impacts of prematurity to the context of overstimulation and fundamental absence in the first months of life in the NICU. Despite demographic variance among participants, certain self-representations and corresponding affect links commonly emerged across cases, providing insight into …
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Cognitive, neuroanatomical and neuroendocrine effects of long-term rotating shift work in a nursing sample
… role in the down-regulation of the HPA axis. Overstimulation of glucocortioid receptors can cause hippocampal atrophy and related cognitive deficits. Research has found that air crew with inadequate recovery time between outbound, transmeridian long-haul flights showed performance decrements …
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Interactions between anticholinesterases in an in vitro central nervous system preparation
… the enzyme acetylcholinesterase (AChE), causing overstimulation within the cholinergic nervous system. If left untreated, this can be fatal. Current medical countermeasures to nerve agent poisoning consist of pretreatment with pyridostigmine and an emergency therapy comprising atropine, diazepam …
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Engineering Intratumoral Cytokine Therapies for Cancer
… against tumor rechallenge, demonstrating that overstimulation of cytokine signaling can dampen memory response. Second, we research design criteria for intratumorally administered IL-2 fused to tumor-specific nanobodies. Using yeast surface display, we develop IL-2 fusions with a range of …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… to maintain low levels of glutamate to prevent overstimulation of glutamate receptors. In neural precursors it has been suggested that glutamate stimulates proliferation by activating metabotropic glutamate receptors (mGluRs) which leads to increased intracellular calcium, however the function …
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The Expressed Emotion of Mothers of Children with Fragile X Syndrome
… & Hagerman, 2002; Miller et al., 1999). This overstimulation often leads to behavioral challenges that are characterized by tantrums, angry outbursts, and other forms of aggression. Additionally, mothers of children with FXS have their own personal challenges that come with carrying the …
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The experience of neurodivergent midwives in Aotearoa New Zealand: An appreciative inquiry
… tools and routines to manage energy levels and overstimulation. Theme four focused on fostering ND kahu pōkai culture and leadership. Participants embraced neurodivergence as a cultural reclamation and strength, advocating for inclusive leadership, peer support, and affirming workplaces that …
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The effect of propofol on α‐amino‐5‐methyl‐4‐isoxazole propionate(AMPA) induced neurotoxicity in rat mixed cortical cultures
… is belived to induce excitotoxic cascade by overstimulation of glutamate receptors such as Nmethyl- D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainite. The pattern of AMPA mediated neurotoxicity (necrosis vs apoptosis) and the neuroprotective effect …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
… Regulation of TLR signalling is essential as overstimulation can cause excessive and pathological inflammation, which leads to serious illnesses such as sepsis and rheumatoid arthritis. Through an N-terminal TIR domain, BCAP interacts with the MAL and MyD88 adaptors downstream of TLR …
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The Influence of Propofol Administration Time on Oxygen Glucose Deprivation-Reperfusion Injury in Rat mixed Cortical Cultures Focused on N-Methyl-D-Aspartate (NMDA) Receptor
… belived to induce excitotoxic cascade mainly by overstimulation of N-methyl-D-aspartate (NMDA) receptors. Propofol have been known to have neuroprotective effects. However, the effect of administration time is not well known with in vitro model. This study was conducted to determine whether the …
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Investigating the molecular signatures of β1-adrenergic receptor activation
… cross-react to β1AR, leading to chronic cardiac overstimulation and heart failure. In this thesis, the production of a published monoclonal antibody fragment was explored, in order to generate a tool for the study of this activation mechanism.
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Contribution à la compréhension de l'immunopathogénie de l'aspergillose nasosinusale chez le chien
… be formulated: the possibility that not the overstimulation of the regulatory branch of the immunity response but an overstimulation of the Th17 branch of the immune response could be the cornerstone of the incapacity of dogs to clear from their SNA. The results of the microarray study were …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… EGFR signaling and protecting cells from overstimulation. The molecular characterization of the NCE pathway led to the identification of a key functional regulator of NCE: the endoplasmic reticulum (ER)-shaping protein, reticulon-3 (RTN3). This regulator is necessary for the formation of …
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The liminal event and its symbols: on the intersection of human and technology
… of shock, which can result from technological overstimulation of human sensorium. This concept is grounded in the psychoanalytical perspective and analyzed in terms of its manifestation through art and cultural production of the twentieth and twenty first centuries. It is a history of the …
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Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
… that undergo excitotoxic neuronal death due to overstimulation of glutamate receptors, Src kinase was found to be cleaved by a calcium-activated protease calpain. In this study, the calpain cleavage site in Src kinase was mapped and a cell-permeable peptide substrate corresponding to this region …
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The Hidden Power of Images: An Allegory of Chaos and Performance in the Digital Age
<p>Within this text, I explore the hidden power of images in American visual culture through painting-based installations. I investigate images of the past and present juxtaposed in a surrealist landscape. Through the use of images in the news, entertainment, advertising, and images within the …