Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"overlapping genes"”.
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Patterns of Two Types of Overlapping Genes in Five Mammalian Genomes
Increasing evidence suggests that overlapping genes is a common phenomenon in eukaryotic genomes too and are not restricted to prokaryotes alone. Here we determined overlapping genes in a set of orthologous genes in the genomes of human, chimp, mouse, rat, and dog and contrasted the patterns of …
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Functional overlap in gene duplications of the yeast Saccharomyces cerevisiae
… of DNA. The presence of extra copies of some genes can result in certain genes performing similar or identical functions as their duplicated counterparts. This study reveals phenotypes for functionally overlapping genes and classifies selected duplicated genes as functionally overlapping or …
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Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
… of the LHb. Each subregion is marked by non-overlapping genes. Cre mouse lines can be used as a tool to target these genes and thus manipulate these subtypes. This project utilizes fluorescence in situ hybridization (FISH) to genetically characterize the Sst-Cre mouse line to target the HbX …
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Evolutionary Analysis of Large-Scale Genomic Changes
… in gene order among species. In the genomes, genes are rearranged through inversion, transposition, translocation, and chromosome fission and fusion. Using gene order as a phylogenetic character has the potential to resolve previously unresolved species relationships. In this study, gene order …
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Extracellular Vesicles as Mediators of Communication Between Endothelial Cells and Fibroblasts
During tissue repair, the peak of angiogenesis is characterized by dense, disorganized and poorly perfused vasculature. As healing progresses, many newly formed vessels regress while surrounding fibroblasts undergo robust proliferation and matrix remodeling. Although fibroblast activation often …
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Regulation Of Transcription By RNA Polymerase II In <i>S. pombe</i>
… to the problems caused by mis-expression of genes that may give rise to a host of human diseases. My thesis research focusses on an analysis of the RNA Polymerase II elongation factor Ell1/Eaf1 in <i>S. pombe</i>. Eleven-nineteen lysine-rich in leukemia (ELL) is encoded by a gene involved in …
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Investigation of Copy Number Variation in South African Patients with Congenital Heart Defects
… against a gene panel of known CHD-associated genes. Candidate genes were considered based on pLI scores and reported CHD phenotypes in mouse models. The identified CNVs were validated by quantifying the read-coverage of available whole-exome sequencing data of a similar overlapping cohort. …
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Complete Genome Sequence and Pathogenicity of Two Swine Parainfluenzaviruses Isolated from Pigs in the United States
… was 15480 nt in length consisting of six non-overlapping genes coding for the nucloeo- (N), phospho- (P), matrix (M, fusion (F), hemagglutinin-neuraminidase (HN) and large polymerase (L) proteins in the order 3'-N-P/C/V-M-F-HN-L-5'. The features related to virus replication and found to be …
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Leveraging gene/subnetwork meta-analysis to recover signal and deconvolute the interactions between genes in the risk of genetic disorders
… single-variant approach, analyzing individual genes or variants in isolation, may not fully capture the intricate genetic architecture of complex diseases. This can be due to genetic heterogeneity or limitations associated with gene-based analysis, where power is lost due to non-effect variants …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… there are many controversial hypotheses about genes regulated by GCs and their gene networks. In particular, two main issues are investigated: (i) GC-regulated genes and (ii) the glucocorticoid receptor (GR) gene networks. Only few overlapping genes have been reported from previous studies. …
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Enhanced transcriptome profiling and biomarker discovery using meta-analytical techniques
… data to detect differentially expressed genes across experiments and conditions, and as a means of classifying unknown samples. Three chapters were created to: (1) investigate three novel meta-analysis approaches as a means of combining and analyzing gene expression experiments for …