Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"overhangs"”.
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Characterization of the Surface Roughness of Overhangs manufactured by Laser Powder Bed Fusion Process using Design of Experiments
Metal Laser Powder Bed Fusion (M-LPBF) is a method of additive manufacturing that enables the fabrication of complex components that would not be possible through conventional manufacturing methods. M-LPBF is well suited for aerospace applications not only because of its ability to fabricate …
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Investigating Poloidal Bias in DNA Minicircles and Overhang influence on DNA Dehybridization
… of DNA and the effects of single stranded overhangs on DNA dehybridization kinetics. The first investigation examines the extreme bending mechanics of DNA by directly probing the anisotropic nature of DNA minicircles through the detection of poloidal bias. We designed an assay using atomic …
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Defining Multiple Steps in Human Telomere End Processing
Telomere overhangs are essential for chromosome end protection and telomerase extension, but how telomere overhangs are generated is unknown. Due to the classic end replication problem, leading DNA daughter strands are initially blunt while lagging daughters are shorter by at least the size of the …
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Procedural generation of features for volumetric terrains using a rule-based approach.
… forms of terrain generation techniques, such as overhangs, arches and caves. While a considerable amount of literature has focused on procedural generation of terrains using heightmap-based implementations, there is little research found on procedural terrains utilising a voxel-based approach. …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
… proteins, and end in 3' protrusions known as overhangs. In mammals, telomeres fold back in structures known as t-loops, in which the overhang is intercalated in the duplex DNA. The length of the TTAGGG tracts was measured (~15 kb) and the presence of 3' overhangs was established in trypanosome …
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Development of a T-Loop Assay to Investigate T-Loop Dynamics and Structure
… extraction) are thus linear and telomeric overhangs are susceptible to digestion by a 3’-5’ exonuclease (ExoI). The “overhangs” in t-loop structures should be resistant to ExoI. If we lower the temperature of Proteinase K digestion to 4°C to reduce the amount of DNA melting that can occur, …
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ARTEMIS AND METNASE MEDIATED PROCESSING OF 3΄-BLOCKED DNA LESIONS: ROLE IN RADIO/CHEMORESISTANCE AND DNA REPAIR
… A 3ʹ-phosphoglycolate moiety on longer overhangs (4 and 6 bases) altered specificity and stimulated Metnase-mediated cleavage of the terminal 3 nucleotides. However, an 8-oxoG residue at the single-strand/double-strand border did not affect specificity or extent of cleavage. Metnase …
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Interactions Between Platinum-Intercalator Hybrid-Agents and The Human Telomeric G-Quadruplex
… 5´-TTAGGG, which end in single-stranded 3´ overhangs that can fold into a non-duplex secondary DNA structure known as G-quadruplex. Because this form of DNA cannot be processed by telomerase, small molecules that induce and/or stabilize the G-quadruplex structure have potential applications …
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3D printing dissolvable support material for time-dependent mechanisms
… support structures strictly for supporting overhangs, we explore use cases derived from its ability to be dissolved when placed in a solvent, such as water. This enables a range of new use cases, such as quickly dissolving and replacing parts of a prototype during design iteration, printing …
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Analysis of continuous folded plate surface
… folded plate surfaces, with and without overhangs at each end, under three load conditions is described. A comparison is made between this general method of analysis and presently accepted techniques; and a final solution for a continuous folded plate surface is presented. The results of …
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Investigating Mechanisms of Telomere End-Protection
… with shRNAs shows a reduction in 3' telomere overhangs and a mild induction of DNA damage signaling. However, deletion of mouse POT1a and –b results in extended 3' overhangs and a massive induction of the DNA damage response. To understand the role of human POT1 in telomere protection, we used …
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Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… the accumulation of excessive telomeric overhangs in mouse cells. I found that POT1b inhibits 5' resection by Apollo at telomeres synthesized by both leading- and lagging-strand DNA replication while promoting the telomeric function of the Ctc1/Stn1/Ten1 (CST) complex. Though the role of …
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The consequences of bank reporting failure for liquidity creation : evidence from accounting restatements
… and triggering the unravelling of risk overhangs that banks accumulate when misreporting. I find that bank liquidity creation declines significantly following restatements for small banks, but not for large banks. Moreover, the decline in bank liquidity creation occurs predominantly …
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A theoretical and numerical procedure for predicting sailing yacht lift and drag
… wave heights at the stern for a hull with overhangs. The influence of viscosity on the outer inviscid flow is modeled using a wall transpiration boundary condition and an edge velocity formula. The boundary layer edge velocity is expressed as a sum of the inviscid velocities and a …
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Effect of oxidative stress on human telomeric DNA structural dynamics and accessibility
… human telomeric DNA consist of single-stranded overhangs of tandem TTAGGG repeats (ssTEL) that can form into a G-quadruplex (GQ). This guanine-rich sequence is prone to 8-oxoguanine (8OG) damage, which is one of the most common oxidative DNA lesions that can compromise telomere integrity. Here, …
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Covalent end-immobilization of oligonucleotides onto solid surfaces
… (ds)DNA molecules with "dangling end" oligo overhangs were immobilized onto the oligo surface by hybridization. Photolysis of psoralen crosslinkers covalently immobilized the dsDNA molecules to the oligo surface. The covalently end-attached dsDNA formed brush-like structures where the dsDNA …
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Witness to the light : the evolution of church sanctuary design & standards of comfort in the last century in Harrison County, Iowa
… built in this county will have less glazing, overhangs to control overheating in the summer, and greater care taken when siting the church.
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Development of Structures and Methods for Safe On Orbit Robotic Assembly of Small Satellites
… features, such as sliding latches and chamfer overhangs, have their performance analyzed by performing repeated insertion tests. It is found that, with compliant designs, a cartesian robot can assemble the designed structure of eight boards and four rails in approximately four minutes.
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Multi-Objective Build Orientation and Topology Optimization for Cost and Time Minimization in Fiber Reinforced Additive Manufacturing
… are temporary features required for fabricating overhangs, can substantially increase print time, material consumption, and overall cost. To address this gap, this research presents a novel multi-objective optimization framework that simultaneously minimizes compliance and support structures, …
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