Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 133 for “"overdose"”.
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New Jersey Overdose Prevention Act: Police Officers’ Experiences At A Drug Overdose Scene
<p>The number of drug overdose deaths in the United States from opioids has led to national attention about the problem commonly described as the “opioid epidemic.” Federal and state policymakers have shifted from a hardline punitive approach to a rehabilitative approach in an attempt to save …
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Preventing Opioid Overdose: From Prediction to Operationalization
… Predicting the most severe outcome (fatal overdose) is a particular challenge due to imbalanced datasets. We partner with Staten Island Performing Provider System to access claims data and electronic health records for the patient population on Staten Island. For this population, we develop …
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Engineering a microneedle patch for opioid overdose therapy
The opioid overdose epidemic, exacerbated by potent synthetic opioids such as fentanyl, presents a critical challenge to public health. Naloxone hydrochloride, a μ-opioid receptor antagonist, is the frontline therapeutic for overdose reversal; however, its clinical utility is constrained by rapid …
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Opioid overdose trends in children, adolescents and young adults
… populations. Aim: This study analyzes opioid overdose mortality in children, adolescents, and young adults to examine trends in opioid overdose mortality within these populations. The aim is to contribute to safer guidance in prescribing opioids to young individuals and reducing mortality …
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Live and let die: opiate overdose deaths in Chicago
… worldwide. One serious outcome of opiate overdose is death. Chicago is an important urban center that has serious opiate overdose-induced death problem that is not clearly understood. The purpose of this study is to better understand factors contributing to death from opiate overdoses, and …
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Reducing opioid overdose-related deaths in Michigan : a policy analysis
… Control and Prevention (CDC) (2020) opioid overdose is the leading cause of mortality and disability among people with opioid use disorder in the United States and in 2020 the CDC reports that 500,000 people died of opioid overdose in the last two decades. The state of Michigan is no …
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The Grieving Process of Opioid Overdose Bereaved Parents in Maryland
… level due to the increasing number of fatal overdoses. This study aimed to explore the experiences of parents who have an adult child who has passed away from an opioid overdose. This study used the Double ABC-X model of family stress theory. Bonadaptation versus maladaptation of each parent …
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A systems toxicology framework for improving the identification of paracetamol overdose
Paracetamol (APAP) overdose is the leading cause of acute liver failure and a concerning global health issue. However, the current clinical treatment framework is heavily criticized for its sub-optimality. Within this thesis, a systems toxicology approach is taken in an attempt to provide further …
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Chronic Pain and The Prescription Opioid Overdose Epidemic: Addressing Provider Attitudes and Concerns
… to an epidemic of prescription opioid related overdose deaths. Primary care providers manage the majority of chronic pain patients in the United States but the care provided is highly variable and often a source of frustration for providers and patients. The purpose of this literature review is …
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ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
Acetaminophen (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial …
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The Political Economy of the Overdose Crisis in Western Canada: An Exploratory Case Study
… Canada is in the throes of a drug/substance overdose crisis causing unprecedented numbers of overdose and death. Responses to the crisis have been largely reactive and/or medical in nature, highlighting the need for better understanding of its underlying structural determinants. The crisis …
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Visualizing global drug flows : transnational connections to the overdose crisis in New England, USA
… synthetic opioid; and (b) naloxone, an opioid overdose antidote used in the public health crisis of drug overdose deaths in Massachusetts, USA. Beginning locally in Massachusetts, I filmed parents reflecting on losing children to overdoses, first responders administering naloxone to save …
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Putting 'Dopamine Overdose' To The Test: A Psychopharmacological Investigation in Parkinson's Disease and Healthy Volunteers
… theoretical framework is known as the dopamine overdose hypothesis. The central aim of this thesis was to critically test the straightforward predictions put forward by this overdose account. First, I examined the effects of dopaminergic therapy on stimulus-reward and reversal learning in groups …
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The Impact of Neighbourhood-Level Marginalization on risk of Opioid Overdose and Opioid Use Disorder
… dimensions of marginalization and risk of opioid overdose (OD) (fatal and non-fatal), fatal OD, and opioid use disorder (OUD). Methods: Data were sourced from administrative datasets housed at ICES. Non-fatal OD was sourced using ICD-10 codes from inpatient, community health, and hospital …
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Survival after local anaesthetic overdose : a comparison of the success of resuscitation after established cardiotoxicity caused by ropivacaine or bupivacaine
The purpose of this thesis is to review the pharmacology and toxicity of local anaesthetics, particularly highlighting the differences between bupivacaine and ropivacaine and to present an experiment attempting to establish whether ropivacaine is a safer drug, once cardiotoxicity has occurred.
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The effects of suicide intent and history of self-harm on emotional reactions and willingness to help
… with information about a hypothetical friend who overdoses. One hundred and forty-two undergraduate students attending Edith Cowan University (Joondalup Campus) were randomly assigned to one of six conditions and read two vignettes. In the first vignette, information was provided of a hypothetical …
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THE HIDDEN HAUNTINGS OF THE OPIOID & OVERDOSE CRISIS: A POLICY REVIEW OF HARM REDUCTION AND SAFE INJECTION SITES IN VANCOUVER, OTTAWA, TORONTO, LONDON, AND WINDSOR.
The drug and opioid overdose crisis have led to the death of hundreds of thousands of people. As such, harm reduction and safe injection sites have been making their appearances throughout Canada, specifically within British Columbia and Ontario. The policies held in Vancouver, Ottawa, Toronto, …
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Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy
… addiction. Seemingly in line with this argument, overdose-related deaths–largely driven by increases in opioid consumption–have soared in recent years, and at the same time an increasing number of states have decriminalized marijuana. Little work, however, has examined the extent to which …
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Large-Scale Online Conversations About Public Health: Predicting Real-World Outcomes
Drug overdose remains one of the most severe public health challenges in the United States. Although online communities contain vast amounts of firsthand accounts, personal experiences, and peer-to-peer discussions about drug use, it is still unclear how these conversations can be analyzed to …
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