Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 7550 for “"overcome"”.
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Drug delivery strategies to overcome ocular hypertension
Glaucoma, a group of ocular diseases that cause optic nerve damage and vision loss, is the second leading cause of irreversible blindness worldwide. Current treatments, primarily eye drops, require frequent administration due to natural tear fluid turnover and blinking, which reduces patient …
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How to Overcome Poverty Traps by Education
… addresses the question of how poverty can be overcome by education. The starting point is the following type of poverty trap: poverty forces parents to send their children to work to secure the survival of the household. Due to child labor, children do not attend school and do not form human …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… inhibitors and adoptive cell therapy, aim to overcome the immunosuppressive tumor microenvironment by blocking key regulatory pathways and exogenously activating immune cells. While effective against some cancers, these therapies are still limited by systemic toxicity, poor delivery kinetics, …
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Structure-activity relationships of niclosamide to overcome colistin resistance
Antibacterial resistance poses a significant threat to global healthcare systems, particularly against Gram-negative bacteria (GNB). Addressing this challenge requires urgent development of new therapies, especially given the emergence of resistance even to last-resort antibiotics like colistin. …
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Moral Matching: Strategic Messaging to Overcome Barriers to Persuasion
<p>Persuasive messages are often met with resistance. Message fatigue is a unique motivational state caused by excessive exposure to redundant messages, which leads to active and passive resistance towards persuasive messages. The consequences of active and passive resistance are particularly …
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Overcome evaluation of an elementary-level diciplinary alternative education placement
Public school systems are required to provide a safe learning environment free of violence and disruption. For students who threaten the learning of themselves or others, schools frequently develop a disciplinary alternative education placement. Students with a history of behavior problems at …
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Molecular interventions to overcome the ageing of CNS stem cells
… order to find possible interventions that will overcome their age-related dysfunction. Recent advances in the generation of induced pluripotent stem cells provide proof that all cells, regardless of age, can be reconverted into embryonic pluripotent stem cells, thereby shedding all the hallmarks …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
Tablets are the most common solid dosage forms because of their several advantages including the ease of administration, precise dosing, ease of manufacturing, good product stability in comparison to liquids, and tamper–proofness in comparison to capsules. Direct compression is the favoured smart …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… we investigated whether p53 activation could overcome MCL-1–mediated resistance to BCL-2 inhibitor ABT-199. We demonstrate that p53 activation by MDM2 inhibitor RG7388 effectively overcomes the acquired or inherent resistance to ABT-199 both <em>in vitro</em> and <em>in vivo</em>. Mechanistic …
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Factors That Overcome Barriers For African American Educators In Educational Leadership
… are the factors these educational leaders had to overcome to move into educational leadership positions.
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Contextualized decision-making to overcome barriers to sanitation and resource recovery
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Drugs, police inefficiencies and gangsterism in violently impoverished communities like Overcome
… of this relationship, in the context of Overcome squatter area in Cape Town. Overcome is representative of other violently impoverished Cape Town communities with its high rate of unemployment, low quality of education, domestic abuse, stagnant housing crisis, lack of access to …
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Tailoring the Geometry of Micron Scale Resonators to Overcome Viscous Damping
Improving the quality factor of the mechanical oscillations of micron scale beams in a viscous fluid, such as water, is an open challenge of direct relevance to the development of future technologies. We study the stochastic dynamics of doubly-clamped micron scale beams in a viscous fluid driven by …
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Inhibition of the endosomal recycling pathway to overcome resistance to cancer therapies
… and treatment regimens are urgently required to overcome this resistance. Recent findings from our own lab and others have found that inhibition of the endosomal recycling pathway may be a promising strategy to downregulate clinically relevant cell surface proteins and to overcome drug …
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