Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"over-express"”.
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Monoamine oxidase in neuronal cell death
… MAO-A and MAO-B, which are differentially expressed in the body and differ in their substrate and inhibitor specificities. Previous studies have suggested that MAO-generated reactive oxygen species (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
… seen in adult transgenic mice that ectopically over express NGF. The overall aim for this project is to examine the morphological and neurochemical features, as well as the overall consequence of sympathosensory plexuses in nerve-injured adult mice and in adult transgenic mice that over express …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
… neuroplasticity that promote changes in protein expression and neuron morphology. Cocaine-induced increases in dopamine ultimately alter dopamine signaling in brain regions modulating reward and motivation, specifically the nucleus accumbens (NAc), and downstream proteins. One protein of …
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Engineering Alkane-Inducible Fimbriation in Escherichia Coli
… In this investigation, E. coli was engineered to over-express fimbriae in response to the presence of IPTG and DCPK. The over-expression of fimbriae in E. coli resulted in a pronounced response to the agglutination of mannose-containing yeast cells, causing them to sediment from solution at a much …
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Functional analyses of ζ-crystallin binding to the 3'-UTR of glutaminase (GA) mRNA
… metabolic acidosis is associated with increased expression of renal glutaminase (GA) that results from selective stabilization of the GA mRNA. LLC-PK1- FBPase+ cells, a pH-responsive porcine kidney cell line, express four distinct GA mRNAs, that are ~2.5, 3.5, 4.5, and 5.0 kb in length. RNase H …
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Characterization of the Group II Intron Gs. Int1 from the Thermophilic Bacterium <em>Geobacillus stearothermophilus</em>.
… with similarity to reverse transcriptase was discovered in the thermophilic bacterium <em>Geobacillus stearothermophilus</em> strain 10 (Vellore <em>et al.</em>, 2004, Appl. Environ. Microbiol. <em>70</em>: 7140-7147). Numerous copies of the intron, designated Gs. Int1, are present in the …
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In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… of binding to those from transgenic mice who over-express MAO-B indicates two possibly distinct populations of [3H]2-BFI 12 sites exist in mouse brain. The data presented here indicates the 2-BFI cue is associated with the selective activation of α1-adrenoceptors and possibly 5-HT receptors. …
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The molecular and behavioral characterization of cav1.3 over-expressing mice
… decline. A line of transgenic mice that over-express the LVGCC Ca<sub>V</sub>1.3 in the forebrain was developed in order to investigate the relative contribution of this change to age-related cognitive decline. These animals were also characterized on both on a molecular and behavioral …
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The Development Of Multivalent Nano-Self Peptides As Antagonists For Antibody-Dependent Macrophage Phagocytosis
… Cancer cells, which are abnormal human cells, express, and sometimes over-express CD47, which is one mechanism used to escape immune clearance. While there has been success in targeting CD47 on cancer cells in the clinic, indiscriminate binding of anti-CD47 antibodies to CD47 on healthy blood …
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Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
… and melanoma cells. Melanoma cells are known to over-express α-melanocyte stimulating hormone receptors. A successful multivalent construct should show greater avidity towards melanoma cells than healthy cells due to the synergistic effects arising from multivalency. Both oligomeric and shorter …
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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
… deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. Our current research uses an improved Modified Vaccinia Ankara poxvirus that we developed to express mesothelin to the murine immune …
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The end-product lactic acid is rapidly expelled from the cytosol by selective monocarboxylate transporters expressed on the plasma membrane. GATA response element islands are …
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Profiling the activity of GPR55 antagonists against recombinant and endogenous GPR55
… (LPI). GPR55 mRNA is expressed widely throughout the body, particularly in the brain, bone and immune tissue, and is also expressed at high levels in certain types of tumour. Understanding the physiological and pathological role of GPR55 has been challenging due to the …
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Role of SFLT-1 in vascular regulation in pregnancy and its effect on fetal vascular programming
… sFlt-1. We have shown that pregnant mice that over-express the sFlt-1 are hypertensive, deliver growth-restricted fetuses, have lower platelet counts compared with controls, and have other manifestations of a preeclampsia-like syndrome. In order to further investigate the underlying mechanisms …
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Characterization of HIV-1 Rev mutants
… observed in HIV infected cells or cells that over-express Rev. Watts et al. hypothesized Rev interacts with MTs by a mechanism shared with Kinesin-13 (Kin13) proteins owing to the presence of a shared amino acid sequence. Kin13 proteins are potent MT depolymerizing agents affecting MT behavior …
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Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction
Tumor and cancer cells that over express heat shock protein 70: HSP70) are found to be multidrug resistant and thermo tolerant, creating a hurdle to existing therapy. Although HSP70 is recognized as an increasingly important drug target, the protein structure of this highly conserved chaperone …
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Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory
… stress responses of adult Drosophila that over-express Sir2 or the nicotinamidase DNAAM. Both of these gene manipulations are known to increase adult lifespan; however only Sir2 endows strong, reproducible resistance to two different forms of oxidative stress. Sir2 is required for normal …
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Dormancy and sprout control in root and tuber crops
… greater prevented sprouting in sweetpotato roots over 4 weeks storage at 25° C. Sprout growth was also inhibited by 1000 ppm aminoethoxyvinylglycine (AVG) (ethylene synthesis inhibitor) or 625 ppb 1-methylcyclopropene (1-MCP) (ethylene antagonist). Continuous ethylene treatment or single 1-MCP …
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Forward programming of human pluripotent stem cells to a megakaryocyte-erythrocyte bi-potent progenitor population: an in vitro system for the production of platelets and red blood cells for transfusion medicine.
… Using a technique called forward programming, we over express three key haematological transcription factors (TFs), pushing iPSCs towards the megakaryocyte lineage, to produce mature megakaryocytes, the platelet precursor cell type. A major limitation of the forward programming technique is a …
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Differential Regulation of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex to rc2 Modulates Aurora A Kinase Expression
… and pancreatic cancers have been shown to overexpress proteins that control cell mitosis, growth, and proliferation. One of those proteins is the Aurora A kinase. Aurora A kinase is a member of a small family of kinases that contribute to mitotic events such as centrosome duplication, …
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