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Showing 1 to 20 of 37 for “"ovalbumin (OVA)"”.

  1. The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model

    서, 동현2014

    … treated withP113(30mg/kg) 30 minutes before OVA challenge. Airway responsiveness (AHR), cell composition and cytokine levels in bronchoalveolar lavage (BAL) fluid were evaluated.Human eosinophil EOL-1 cells were treated with LTE4 with or without pre-treatment of P113. Intracellular expression …

    ajou Repository record

  2. Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory

    Saldanha, MarshaUniversity of Ottawa (Canada)2013

    … T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell activation, and Listeria monocytogenes (LM) which induces massive T cell activation, the influence of T cell stimulation on memory development …

    ottawa-retro Repository record

  3. Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter

    Toben, Catherine GiselaUniversität Würzburg

    … specifically expressing the neo-antigen (Ag) ovalbumin (OVA) in either the central nervous system (CNS) or peripheral nervous system (PNS) were to be generated. The myelin basic protein (MBP) is a major component of the myelin sheath both within the CNS and the PNS. Therefore the MBP promoter …

    wurz-thes Repository record

  4. Delivery of antigens to dendritic cells as a platform for a vector-free cancer therapy

    Mao, ShirleyMassachusetts Institute of Technology2014

    … intracellular delivery could be achieved. Then ovalbumin (OVA) was delivered as a model protein to assess the system's capability to prime dendritic cells against a particular antigen. Dendritic cells activated post-delivery were then cultured with isolated primary T cells in-vitro to determine …

    mit Repository record

  5. Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice

    Blankson, Joel Nee-Lartey

    … cells to a superantigen was followed by priming ovalbumin (OVA) specific αβ T cell receptor transgenic mice with SEB. Cells from these mice appeared to be anergic in that they were hyporesponsive to OVA peptide as well as to SEB. The anergic cells could respond to PMA and ionomycin suggesting …

    rockefeller Repository record

  6. Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma

    Duncombe-Moore, JosephineUniversity of Strathclyde2017

    … ES-62 has been previously shown to inhibit ovalbumin (OVA)-induced airway allergy. Additionally, the small molecule analogue 12b based on the ES product has been found to alleviate inflammation in a house dust mite extract (HDME) allergy model.;The intention of this study was to identify …

    strathclyde Repository record

  7. Mechanical and Cellular Response to Biomineralization of Ovalbumin Scaffolds for Bone Tissue Engineering

    Sheets, KevinVirginia Tech2010

    Studies regarding the feasibility of ovalbumin (OVA) as a bone scaffold material have found its cost, availability, interaction with cells, and ability to degrade in the body into safe byproducts to be ideal for such an application. However, weak mechanical properties cause hesitation in the use of …

    vt Repository record

  8. Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools

    Vadakekolathu, JNottingham Trent University2013

    … this study were derived from TRP-2 ‘self’ and ovalbumin (OVA) ‘foreign’ antigens. Immunisation of animals with these antigens in a DNA vaccine format induces a high avidity T cell response, in contrast to the response when these are administered in the peptide vaccine format. However, both the …

    nott-trent Repository record

  9. THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA

    Hong, Soram2014

    … allergic lung inflammation entailed transferring ovalbumin (OVA) specific CD4+ T cells into normal BALB/c mice which then inhaled OVA for 7 days. Mice were treated daily with either CB2 compound or vehicle, and the anti-inflammatory effect of the CB2 agonist was examined by monitoring the effect …

    montana-tech Repository record

  10. THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA

    Hong, Soram2014

    … allergic lung inflammation entailed transferring ovalbumin (OVA) specific CD4+ T cells into normal BALB/c mice which then inhaled OVA for 7 days. Mice were treated daily with either CB2 compound or vehicle, and the anti-inflammatory effect of the CB2 agonist was examined by monitoring the effect …

    montana Repository record

  11. Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression

    Potts, Amelia2024

    Ovarian cancer is the most fatal gynecological malignancy, with high-grade serous ovarian cancer (HGSC) being the most commonly diagnosed and aggressive subtype. Although HGSC initially responds well to debulking surgery and platinum-based chemotherapy, approximately 80% of patients experience …

    queens Repository record

  12. Soluble Peptide Treatment Reverses CD8 T Cell-Induced Disease in a Mouse Model of Spontaneous Tissue-Selective Autoimmunity

    Paek, So Yeon2011

    … murine model of autoimmunity by crossing K14-sOVA mice, which express soluble chicken ovalbumin (OVA), with OT-1 mice, whose CD8 T cells express V2/V5 regions of the T cell receptor that are specific for SIINFEKL peptide (OVA 257-264) in association with class I MHC molecules. The …

    utswmed Repository record

  13. The regulation of allergic airway disease by type V collagen-induced tolerance

    Lott, Jeremy M.2013

    … with col(V) prior to sensitization with ovalbumin (OVA), and subsequent OVA intranasal challenge. Airway hyper-responsiveness (AHR) to methacholine was measured; and RT-PCR utilized to determine local Il17 transcripts. Bronchoalveolar lavage levels of C3a¸ C5a and OVA-specific IgE were …

    iupui Repository record

  14. THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE

    Strainic, Michael George, JrCase Western Reserve University School of Graduate Studies2013

    … this, a.c. pre-injection or oral pre-feeding of ovalbumin (ova) in WT mice and in WT chimeras possessing Daf1–/–C3aR–/–C5aR–/– bone marrow (BM) but not Daf1–/– BM increased ocular TGF-ß1 production, induced iTregs, and suppressed subsequent ova-specific DTH, CD4+, CD8+, and IgG2ab responses. …

    ohiolink Repository record

  15. Ovalbumin-Based Scaffolds Reinforced with Cellulose Nanocrystals for Bone Tissue Engineering

    Glaesemann, Benjamin PaulVirginia Tech2011

    … to prevent immediate failure upon implantation. Ovalbumin (OVA), a glycoprotein from chicken egg whites, has been use to fabricate biodegradable, porous hydrogel bone scaffolds that promote osteoblast attachment and proliferation. Although ovalbumin scaffolds encourage bioactivity and are …

    vt Repository record

  16. Production and characterisation of novel recombinant antibody fragments against sialic acid

    Donohoe, Gerard GaryDublin City University2011

    … was biopanned using a depletion protocol and two ovalbumin (OVA) conjugates, Neu5Gc-linker1-OVA and linker1-OVA. ELISA analysis, SPR inhibition and ‘off-rate’ studies identified one mutant clone, E15, which displayed strong affinity for conjugates of sialic acid. A solution-phase SPR-based …

    dcu Repository record

  17. A Microfluidics-Based Approach For Isolation of Antigen-Specific Cd8+ T Cells

    Frank, Meredith, <p>0000-0002-3658-0057</p>2023

    … I and II Histocompatibility) within the model Ovalbumin (OVA) antigen system. Using a <em>de facto </em>pool of peptide-loaded MHC class I molecules on the surface of target cells, ATTACH enriches for antigen-specific CD8<sup>+</sup> T cells based on binding avidity to cognate antigens. Here, I …

    uthsc Repository record

  18. Peptide immunotherapy in models of allergic airways disease

    MacKenzie, Karen JoanThe University of Edinburgh2011

    … aid translation to the allergy clinic. Chicken ovalbumin (OVA) is a commonly used model allergen in mouse models of allergic airways inflammation (AAI). Trackable, T cell receptor transgenic T cells recognizing the immunodominant 323-339 peptide of OVA (pOVA) allow mechanistic investigation of …

    edinburgh Repository record

  19. Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy

    He, XianghuiThe University of Arizona.2003

    … class I restricted antigenic epitopes of chicken ovalbumin (OVA), tyrosinase related protein 2 (TRP-2), and oncoprotein HER2 into the signal sequence of the interleukin-2 (IL-2) gene, replacing part of the signal sequence at different positions. Our results showed that these modified signal …

    arizona-thes Repository record

  20. Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis

    Scibiorek, MartynaDepartment of Clinical Laboratory Sciences2021

    … 3 models of AD using House dust mite (HDM), Ovalbumin (OVA) and low-calcemic analog of vitamin D (MC903) on mouse strains lacking IL-4Ra on various B and T cells. We used mb1creIL-4Rα-/lox (mice lacking IL-4Rα on B cells), iLcKCre IL-4Rα-/lox (mice lacking IL-4Rα on all T cells), LcKCre …

    cape-town Repository record

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