Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 308 for “"outgrowth"”.
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The Molecular Regulation of Spinal Nerve Outgrowth
During amniote embryogenesis, the segmented pattern characteristic of the vertebral column appears early during development through the sequential formation of multipotent structures called somites. Somites differentiate subsequently into dermomyotome (giving rise later to skin and skeletal …
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… in addition to the assessment of neurite outgrowth in PC12 cells. Therefore, to test the role of DM, a sigma-1 compound, glutamate NMDA antagonist, and DM metabolite-dextrorphan were used in both MBT and a neurite outgrowth assay. Marble burying data revealed a significant decrease in …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
… in a significant number of patients. Early outgrowth cells (EOCs) represent a novel bone marrow-derived cell population that have been recently described to have tissue protective activity. In this work, we examined the effects of intravascular EOC infusion in two independent models of CKD, …
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Microenvironment-Induced Pten Loss By Exosomal Microrna Primes Brain Metastasis Outgrowth
… critically impacts the subsequent metastatic outgrowth. Yet, it is unclear when and how disseminated tumor cells acquire the essential traits from the microenvironment of metastatic organs that prime their subsequent outgrowth. Here we show that primary tumor cells with normal expression of …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… cysteines (SPARC) as a mediator of OEC-induced outgrowth in vitro. To test the contributions of SPARC to spinal cord repair after OEC transplantation, cultures of LP OECs from SPARC null and wildtype (WT) mice were transplanted into a crush of the dorsolateral funiculus. Substance P and tyrosine …
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… inhibitor, lovastatin, promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, lovastatin also contradictorily relieves or exacerbates memory loss in Alzheimer's patients (Wagstaff et al., 2003; Sparks et al., 2008). …
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THE ROLE OF NADPH OXIDASE IN NEURITE OUTGROWTH AND ZEBRAFISH NEURODEVELOPMENT
Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are a family of enzymes that produce reactive oxygen species (ROS). The first NOX enzyme was discovered in leukocytes and associated with host defense in the immune system. Subsequent findings of ROS production in non-immune cells led to …
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Valproic acid: A neural outgrowth model for the autism spectrum disorder
1 PDF file (vii, 43 pages)
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Self-rolled-up microtube technology for cellular outgrowth guidance and monitoring
The evolution and optimization of self-rolled-up membranes (s-RuM) has been taking place over the past two decades at a fervent pace. This progress has culminated in a rolled-up structure that is not only insulating, but transparent and biocompatible, allowing it to be integrated into conductance, …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… of high potassium media inhibited neurite outgrowth, an effect that was blocked by Co²+ or Cd²+. Glutamate application in the presence of [omega]-conotoxin MVIIC still inhibited neurite outgrowth, suggesting calcium influx via chemically-gated channels may also contribute. Particularly, …
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Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
Rolle des 5-HT7/G12 Signalwegs bei der Morpho- und Synaptogenese. Der Neurotransmitter Serotonin (5-Hydroxytryptamin oder 5-HT) moduliert, zusätzlich zu seiner Funktion als Neurotransmitter, verschiedene Aspekte der frühen neuronalen Differenzierung, einschließlich des Neuritenwachstums und der …
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Fgf4 and Wnt5a/Pcp Signaling Promote Limb Outgrowth by Polarizing Limb Mesenchyme
… whereby fibroblast growth factors (FGFs) mediate outgrowth of the limb. Specifically, we examined the epistatic relationship between FGF and Wnt/Planar cell polarity (PCP) signaling in establishing cell polarity as a mechanism for outgrowth. By implanting beads into embryonic limbs and lateral …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… disorders. We performed neurite outgrowth studies on cells treated with lovastatin and found statin administration increased neurite branching. Global inhibitors do not give us a good indication of what is causing the observed effect as they do not implicate how inhibiting the …
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Investigation of the role of neuroserpin in neurite outgrowth and learning and memory
… has been shown to play a role in neurite outgrowth but con icting results have been reported. Neuroserpin has also been proposed to play a role in learning and memory but direct evidence for such a role is lacking. e overall goals of this thesis were to further investigate a role for …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
… an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in …
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Soybean lunasin mediates colon carcinogenesis by inducing apoptosis and preventing outgrowth of metastasis
… resulted in a more potent inhibition of outgrowth of KM12L4 cell metastases to the liver reducing the number of liver metastases by 6-fold and reducing the tumor burden in the liver by 3-fold when compared to PBS-treated group. This can be attributed by the capability of lunasin and …
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Genetic and molecular analysis of genes required for axon outgrowth in Caenorhabditis elegans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1993.
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