Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"outflow tract"”.
-
The Role of Sonic Hedgehog in Outflow Tract Development
<p>The two major contributing populations to the outflow tract of the heart are the secondary heart field and the cardiac neural crest. These two populations are responsible for providing the myocardium that supports the outflow tract valves, the smooth muscle that surrounds these valves and the …
-
Development of a Toolkit to Investigate Endocardial Endothelial Cellular Response in Left Ventricular Outflow Tract Pathologies
… cells (EECs) that line the left ventricular outflow tract (LVOT), modeling the elevated wall shear stress (WSS) observed in DSS patients, and creating a tunable scaffold that can be used to investigate the effect altered mechanical environments have on cells in the LVOT. With this toolkit, I …
-
Effect of ivabradine, a novel I<sub>f</sub> current inhibitor, on dynamic obstruction of the left ventricular outflow tract in cats with preclinical hypertrophic cardiomyopathy: a single-dose study
… dynamic obstruction of the left ventricular outflow tract and mitral regurgitation secondary to hypertrophy of the left ventricle and systolic anterior motion (SAM) of the mitral valve. This leads to an increase in left ventricular systolic pressure, and thus wall stress, that may ultimately …
-
Optimal Analytical Methods for High Accuracy Cardiac Disease Classification and Treatment Based on ECG Data
… ventricular arrhythmia from right ventricular outflow tract to left ventricular outflow tract. In the third project, Principle Component Analysis (PCA) application in classification problem was studied. PCA is a commonly used technique to reduce dimensions of the data through analyzing …
-
Outflow Reconstruction using Cryopreserved Aortic Patch in Right Lobe Living Donor Liver Transplantation
… technique using cryo-preserved aortic patch for outflow reconstruction of right lobe graft with or without MHV. MATERIALS AND METHODS: From November 2005 through March 2006, 20 adult patients who received right lobe graft(n=10) or extended right lobe graft(n=10) for LDLT were included. During the …
-
Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… embryos. As the heart matures, formation of the outflow tract is vital to establish appropriate connections with the vasculature. This process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great …
-
Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… embryos. As the heart matures, formation of the outflow tract is vital to establish appropriate connections with the vasculature. This process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great …
-
The Chemokine Receptor CXCR7 Functions in Endocardial-Derived Cells to Regulate Cardiac Valve Remodeling
… of heart development, proper separation of the outflow tract and chambers, and correct connection to the existing vascular system are critical to ensure unidirectional blood flow and supply of oxygenated blood to the rest of the body. Cardiac neural crest cells and endocardial cushions …
-
Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
… cells of the atrioventricular canal and the outflow tract repress endothelial cell phenotype and upregulate mesenchymal cell phenotype. EndMT is initiated by inductive signals emanating from the overlying myocardium and inter-endothelial signals and generate the cells that form the heart …
-
Pulmonary Valve Replacement
… been used off-label in native right ventricular outflow tract (RVOT). It is currently under clinical trial to get food and drug administration (FDA) approval.</p> <p>This study is a comparison of the performance of Sapien 3 with surgical bioprosthetics. The in vitro tests result showed Sapien 3 …
-
The NEST study: NICOM vs ECHO in the screening of transient hypertrophic obstructive cardiomyopathy (HOCUM)
… of cardiac output and left ventricular outflow using an array of techniques from electrical bioimpedance to transthoracic bioreactance. The appeal is that these investigations can be carried out at the patient’s bedside without a trained ECHO (Echocardiogram) technician. Aim: Our primary …
-
Analysis of Band 4.1B In Integrin-Mediated Cell Adhesion and Signaling
… These embryos displayed malformation of the outflow tract that was likely linked to abnormal regulation of cardiac neural crest migration. These data indicate the importance of cooperative signaling between β8 integrin and Band 4.1B in cardiac development. The involvement of Band 4.1B in …
-
Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… known to aid in the development of the cardiac outflow tract (OFT), valves, and interventricular septum, during embryogenesis. <em>Yap </em>and <em>Taz </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role …
-
Adipose-Derived Stromal Cells Contribute To Spinal Cord Repair But Are Not Neural-Crest Derived Stem Cells
… and neck, smooth muscle cells of the cardiac outflow tract, and melanocytes among others. Given the reported ability of neural crest-derived cells and ADAS cells to give rise to bone, cartilage, muscle, and nerve tissues, I hypothesized that ADAS cells might be neural crest-derived cells that …
-
Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
… majority of the head, the septum of the cardiac outflow tract (OFT), smooth muscle subpopulations, sympathetic nervous system and many other organs. Anomalous NCC morphogenesis is responsible for a wide variety of congenital defects. Importantly, several individual members of the TGFβ superfamily …
-
The Green Lane Valve: a Novel Decellularised Heart Valve
… decellularised heart valves implanted in either outflow tract position, compared with standard tissue conduits. A novel subcutaneous rat model for the assessment of scaffold immunogenicity was developed. Bovine pericardia decellularised using a proprietary protocol were evaluated using the …
-
The role of myocardial fibrosis and ventricular mechanical dyssynchrony in the pathogenesis and treatment of contractile myocardial dysfunction.
… dyssynchrony refers to the incoordinate contraction of the ventricles: inter-ventricular dyssynchrony is the temporal uncoupling of left from right ventricular contraction, and intra-left ventricular dyssynchrony pertains to heterogeneity in the time to regional mechanical activation within …
-
Detection of Genes Influencing Chronic and Mendelian Disease Via Loss-of-Function Variation
… sequence from 342 unrelated left ventricular outflow tract obstruction (LVOTO) cases to ARIC sequence, identifying genes harboring case-exclusive LOF mutations. Comparison to an <em>a priori</em> list of cardiac candidate genes revealed 28 genes potentially related to LVOTO, including 22 not …
-
Right Ventricular Structure and Function in Elite Athletes in Relation to Pre-Participation Screening
… participants. Patients with ARVC had larger RV outflow tract (RVOT) diameter at short-axis view (mean SD; 34 vs. 28 mm P<0.001) and RV end-diastolic area (23 vs. 18 cm2 P<0.001) compared to healthy controls. ARVC patients also had lower value on conventional and global RV strain (ε) …
-
PULMONARY ARTERY STIFFNESS IN RACEHORSES AFFECTED BY EXERCISE-INDUCED PULMONARY HEMORRHAGE
… parasternal angled view of the right-ventricular outflow tract, and repeatability/reproducibility were assessed. Intra-operator agreement was excellent, while inter-operator agreement ranged from moderate to excellent. A systematic “window effect” was also observed: compared with the conventional …
Page 1 of 2