Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"ototoxic"”.
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Effects of Korean Red Ginseng against Ototoxic Drugs and Age-related Cochleo-vestibular Dysfunction
… (2) the protective effects of KRG in an ototoxic animal model BALB/c mice using 3-NP; (3) the effects of KRG on age-related hearing loss (AHL) and balance disturbance in C57BL/6 mouse. In the first study, Sprague-Dawley rats were classified into GM group (n = 12) and KRG+GM group (n = …
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The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
Apoptosis is essential during development and for maintenance of healthy tissues. Dysregulation of apoptosis has thus been found to contribute to many pathologies, including neurodegenerative disorders, as well as to tumor promotion. Normal cellular processes that involves oxygen result in the …
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A profile of the auditory function of children with TB receiving ototoxic medication at Brooklyn Chest Hospital
… of children with tuberculosis (TB) receiving ototoxic medication at Brooklyn Chest Hospital. A battery of audiologic tests (otoscopy, immittance, audiometry or OAE and AABR) were conducted on 29 children, aged 0 to 18 years, and the results were analysed using descriptive statistics and …
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Distortion product otoacoustic emissions: towards reliable and valid early identification and monitoring of hearing in adults receiving ototoxic medication
… as part of their treatment. These drugs are ototoxic, and can cause permanent damage to the cochlea, resulting in a debilitating hearing loss, which has a negative impact on an individual's quality of life. Early detection and management of an ototoxic hearing loss can minimise the impact of …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not establish whether a pathway is protective, maladaptive, or merely reactive in the intact mammalian cochlea. This dissertation tests the hypothesis that Janus kinase/signal transducer and …
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
… with cisplatin are exposed to high risk of ototoxicity such as hearing loss or dizziness. It has been reported that ototoxicity occurs in about 75-100 % of patients treated with cisplatin and shows irreversible, cumulative and bilateral characteristics. However, cisplatin-induced ototoxic …
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Ototoxicity Monitoring using Automated Extended High-Frequency Audiometry and the Sensitive Range of Ototoxicity in Patients with MDR-TB
… are damaging to the cochlea and auditory nerve (ototoxic) and can lead to permanent hearing loss and/or balance disorders. Ototoxicity monitoring aims to reduce this burden by preventing or minimising the damage caused by ototoxic treatment as it can progress and worsen speech perception …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
… of tumor necrosis factor alpha (TNF[alpha]), an ototoxic cytokine whose VS secreted levels correlate with degree of SNHL, led to neurite loss in cochlear explants and TNF[alpha] neutralization in VS secretions partially rescued cochlear degeneration due to VS secretions. Interestingly, …
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
… drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use.
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Optimizing Conditions for Cloning cDNA from Chicken Brain
… cells which are damaged by acoustic trauma or ototoxic drugs may be replaced by regeneration. As the first step in determining the molecular mechanisms of hair cell regeneration, gene expression techniques including cDNA synthesis and cloning were attempted first with the chicken brain. The …
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Role of pericytes in the barrier task
… pericytes (BCPs) and to test the effects of some ototoxic drugs on these BCPs. The use of BCPs for the analysis of ototoxic drugs can be a model to investigate pharmacological mechanisms and protection systems against different insults.
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Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis
… which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients undergoing treatment for MDR-TB for early detection of ototoxic hearing loss to facilitate alerting the patients and relevant medical staff about the presence and progression of any …
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Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
… of sensory- deficient hair cells to resist ototoxic insults, and the proliferative and regenerative properties of the lateral line organ. To look at the regeneration capabilities of MET mutants, ablation methods were used to target sensory hair cells using the OptoBax system in zebrafish.
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
… the inner ear, environmental auditory insults, ototoxic medications and idiopathic sudden sensorineural hearing loss, and presbyacusis (hearing loss in elderly patients). The vestibular portion of the inner ear is also susceptible to disease including Meniere's disease, vestibular neuronitis, …
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A fully implantable intracochlear drug delivery device : development and characterization
… an immediate application in the treatment of ototoxic and inflammatory conditions affecting the inner ear, including autoimmune inner ear disease and cisplatin-induced ototoxicity. Current efforts include ongoing refinement of the design, miniaturization of components, and testing in an in …
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Melanin as an Oto-Protective Pigment in Two Fish Species: <i> Poecilia Latipinna </i> and <i>Cyprinus Carpio </i>
… interacts with stress from acoustical trauma and ototoxic drugs.</p>
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… role in hearing loss (HL) caused by different ototoxic insults including anti-neoplastic agents such as cisplatin, aminoglycosides and acoustic trauma. These insults can trigger chronic production of reactive oxygen species (ROS) in regions of cochlea such as organ of Corti, stria vascularis …
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Genetic and pharmacokinetics factors associated with susceptibility to kanamycin induced cochleotoxicity in a cohort of patients undergoing MDR/RR-TB treatment
… should be used for MDR/RR-TB patients. A routine ototoxic monitoring programme (at least once a month) including ultra-high frequency audiometry should be implemented for MDR/RR-TB patients who receive aminoglycosides, from the time of ototoxic drug exposure until six months post treatment. …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… damage can result from factors such as disease, ototoxic insult, excessive noise and age. Because treatments for hearing loss are limited, scientists are looking to the use of transgene expression as a means of regenerating hair cells from nearby support cells. One possible means of transgene …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… damage can result from factors such as disease, ototoxic insult, excessive noise and age. Because treatments for hearing loss are limited, scientists are looking to the use of transgene expression as a means of regenerating hair cells from nearby support cells. One possible means of transgene …
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