Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"osterix"”.
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Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations
… runt-related transcription factor 2 (RUNX2) and Osterix (OSX), with interplay from signaling pathways such as the Bone Morphogenetic Protein (BMP) network. MSCs isolated from bone marrow (BM) and adipose tissue (ADI) are most commonly utilized in human and veterinary regenerative medicine …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… and fracture repair. First, YAP and TAZ in Osterix-expressing cells combinatorially promoted bone development and growth by regulating osteoblast function, paracrine regulation of osteoclastic remodeling, and bone matrix quality. Furthermore, combinatorial YAP and/or TAZ deletion from …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
… treatment caused a biphasic effect on ALP and osterix mRNA levels. At low dose, it increased expression levels and at high dose it decreased the expression levels of ALP and osterix genes. Since thyroid hormone action in the nucleus is known to be mediated via binding of thyroid hormone …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… of predominantly post-mitotic <italic>Osterix+</italic> cells on trabecular bone surfaces. Manipulation of Smad4 in osteoprogenitor cell lines indicates this effect is accomplished, at least in part, by the ability of BMP signals to stimulate physical recruitment of beta-catenin to the …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… via repressing the transcription of osterix, an essential osteoblast differentiation factor. Inactivating p53 rescues osteoblast differentiation defects of mice lacking c-Abl, a p53 interacting protein. We provide evidence that c-Abl, a non-receptor tyrosine kinase, acts at a novel …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… genes, including Bmp2, Msx2, Runx2 and Osterix. By using the same strategy to conditionally delete Rb in p107/- embryos, we observe lethality at approximately e14.5 during development.
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Effect of Implant Surface Microtopography by Hydroxyapatite Grit-Blasting on Adhesion, Proliferation and Differentiation of Osteoblast-like Cell Line, MG-63
… makers (osteonectin, type I collagen, Runx-2, osterix). Similar data was represented in the ELISA that RBM surface increased secretion of osteocalcin, osteopontin, TGF-beta1 and PGE2 which was known to stimulate the osteogenesis. Moreover, alizarin red-s staining revealed that there were …
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Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
… Chd7 targets including bone formation regulators Osterix/Sp7 and Creb3l2, which are also critical for oligodendrocyte maturation. Thus, Chd7 coordinates with Sox10 to regulate the initiation of myelinogenesis and acts as a molecular nexus of regulatory networks that account for the development of …
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Comparative osteogenesis of equine mesenchymal stem cells isolated from bone marrow, adipose tissue, and synovium
… of ALP and osteoblast-specific genes Runx2, Osterix, Osteonectin and Osteomodulin. Staining of the mineralized matrix of BM-MSCs cultured under osteogenic conditions, demonstrated a higher uptake of both Alizarin Red (AR) and Von Kossa (VK) stains, restricted to dense cellular aggregation …
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Osteogenesis During Early Healing Around Titanium and Titanium Zirconium Implants: Immunohistochemistry and mRNA Expression of Bone Markers in Miniature Pigs
… RNA was isolated from two animals at 2 weeks; Osterix(Osx), Opn and Ocn mRNA expression levels were evaluated for osteoblasts differentiation by QRT-PCR. <strong>Results: </strong>No significant histological difference was recorded between the different implant types at each sacrifice time …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… for osteogenic genes alkaline phosphatase (ALP), osterix(OSTX), osteonectin (OSN), and runt-related transcription factor 2 (RUNX2). Circulating FGF2 levels were quantified in the plasma of dogs with naturally occurring OS (determined to be osteoblastic or osteolytic based on relative bone mineral …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
… of various osteoblast lineage cell subsets (Osterix (Osx), Dentin Matrix Protein-1 (Dmp1), 3.6Col1) to osteogenesis and angiogenesis necessary for bone repair. From these studies, we determined that pre-existing osteoprogenitor (Osx+ lineage) cells but not more mature osteoblasts (Dmp1+ …