Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"osteosarcomas"”.
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
… ablate superficial soft tissue sarcomas (STS), osteosarcomas (OS), and brain tumors and considers the immunological impacts of histotripsy treatment for STS and OS. The research described herein (1) investigates the ability of histotripsy to treat superficial STS tumors in companion animals with …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… gene therapy for the treatment of experimental osteosarcomas. Subcutaneous implants of mixtures of tumor cells and HS-tk vector producer cells (vpc) resulted in the development of tumors which were completely cured upon administration of GCV. Subcutaneous implant of mixtures of transduced and …
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Expression of ICAM-1, MHC-1 and B7 surface molecules in canine primary appendicular osteosarcoma
… to determine whether canine primary appendicular osteosarcomas express ICAM-1, MHC-1 and B7 molecules which are critical in eliciting optimum immune response. Cell lines and tissue sections (frozen and paraffin-embedded, formalin-fixed tissues) of dogs with osteosarcoma were analyzed using …
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Attitudes and Practices of Genetic Counselors In Providing Predictive Testing to Minors At Risk For Li-Fraumeni Syndrome
… including breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, and adrenocortical carcinomas. Individuals found to carry germline mutations in <em>TP53</em> have a 90% lifetime cancer risk, with a 20% chance to develop cancer under the age of 20. Despite the significant risk of …
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Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven By Different P53 Mutants
… gain of function. RNA-sequencing of primary osteosarcomas revealed that tumors expressing these missense mutants had vastly different gene expression profiles as compared to <em>p53</em>-null tumors. Further, p53R172H and p53R245W regulated unique transcriptomes, that affected distinct …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
… from p53-deficient, mesenchymal stem cells: osteosarcomas predominated in the presence of Rb, while Rb loss strongly favored brown fat tumors. Thus, to directly address the influence of Rb status in mesenchymal tumorigenesis we used inducible systems to control pRB's expression. Our data …
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Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis
… overlap in the mouse tumors (fibrosarcomas and osteosarcomas). Recurrent data discovered in the mouse was mirrored in some human sporadic mesenchymal tumors, including novel genes like <em>MROH2A, and MIR219A2. </em>Our results emphasize the utility of a model disorder and comparative omics to …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… using tissues and reagents from murine and human osteosarcomas. Using overexpression and knockdown techniques we modulated eIF4E expression in murine and human osteosarcoma cell lines and then evaluated the consequences at various steps within the metastatic cascade in vitro and in vivo. We found …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… then to osteoblasts (OBs), the cells from which osteosarcomas originate. Interestingly, LFS iPSC-derived osteoblasts recapitulated the osteosarcoma phenotype, creating “a bone tumor in a dish”. This “tumor in a dish” platform proved that LFS is an ideal model system to study and modeling LFS …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… ablation, including pancreatic adenocarcinoma, osteosarcomas, and soft tissue sarcomas. Pigs share many similarities with human anatomy and physiology, making them an ideal model organism for testing new medical devices and regimes for treating new targets. Using pigs, we were able to establish …
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Effectiveness of mifamurtide in addition to standard chemotherapy for high-grade osteosarcoma: a systematic review
… growth in children and adolescents as high-grade osteosarcomas. Current treatment recommended for high-grade non-metastatic and metastatic and/or relapsed osteosarcoma involves neoadjuvant multiagent conventional chemotherapy, followed by surgical resection of macroscopically detected tumour and …
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Ανάπτυξη υπολογιστικής μεθοδολογίας εξόρυξης, ανάλυσης και παρουσίασης δεδομένων πρωτεωμικής καρκινικών δειγμάτων
Τα πεπτίδια, είτε ως πρωτεϊνικά θραύσματα είτε ως φυσικές οντότητες, χαρακτηρίζονται από την ακολουθία τους και από τα λειτουργικά τους χαρακτηριστικά. Ο σκοπός αυτής της Διδακτορικής Διατριβής είναι η ανάπτυξη μιας μεθοδολογίας εξόρυξης δεδομένων για μοναδικά tags και πεπτιδικά/πρωτεϊνικά …