Global ETD Search
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Showing 1 to 3 of 3 for “"osteosarcomagenesis"”.
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Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven By Different P53 Mutants
<p>Missense mutations in the DNA binding domain of the <em>Trp53</em> gene are characterized as structural (<em>p53R172H</em>) or contact (<em>p53R245W</em>) mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities such as increased …
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Increased Oxidative Phosphorylation In An Ipsc- Derived Model of Rothmund-Thomson Syndrome Associated Osteosarcomagenesis
… during differentiation may be important during osteosarcomagenesis. During differentiation, increased oxidative phosphorylation related genes, specifically transcription of genes which encode complex I of the electron transport chain, were upregulated. We next demonstrated that the observed …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… cancer drivers that contribute to LFS associated osteosarcomagenesis. We found that LFS patient derived OBs exhibit both <em>in vitro</em> and <em>in vivo</em> oncogenic properties. We also observed increased somatic mutation prevalence in LFS OBs derived tumors compare to LFS OBs. Genes that are …