Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"osteoprogenitor cells"”.
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Cellular Responses to Short-Term Mechanical Loading: Relative Involvement of Osteoblasts, Pre-Osteoblasts, and Osteoprogenitor Cells
Bone is an organ that is highly sensitive to changes in its mechanical loading environment. Although it is known that increased mechanical loading results in new bone formation, the cellular mechanisms underlying this response remain unclear. This investigation applied in vivo and in vitro …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
… of a biomaterial scaffold, pharmaceutics, and osteoprogenitor cells. One source of osteoprogenitor cells is bone marrow stroma, which can be obtained from the patient - minimizing the risk of an immune response - directed in vitro to proliferate, and differentiate into a bone-like tissue. To …
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Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
… effects of mechanical loading of osteoblast-like cells include increased proliferation, changes in collagen production and increased prostaglandin formation. No in vitro study has reported increased bone formation nor has been able to determine if mechanical load induces differentiation of …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… concentrations with respect to their effects on osteoprogenitor proliferation, osteogenic differentiation, cell culture mineralization and cell migration. BCSPs appeared to enhance the bone growth in the previous study using an animal model; however, the cellular and molecular mechanisms of BCSPs …
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
… calcium and phosphate ions to differentiating osteoprogenitor cells, thereby stimulating osteogenesis when implanted in vivo. In this research, the effect of zinc on the differentiation of osteoprogenitor cells was investigated. Zinc supplementation of the culture media had no stimulatory …
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Non-invasive shock wave stimulated periosteum for bone tissue engineering
The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock waves (ESWs) have been reported to cause thickening of the cambium layer and …
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Controlled release of gentamicin from polyelectrolyte multilayers to treat implant-related infection
… products were generally nontoxic toward MC3T3-E1 osteoprogenitor cells. A reproducible in vivo rabbit bone infection model was developed to test the PEM coatings against sterile, uncoated placebos; subsequent in vivo experimentation demonstrated the proof-of-principle that an antibiotic-eluting …
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Biodegradable polymer scaffold fabrication and the creation of tissue-engineered bone
… believe this tissue may have a large number of osteoprogenitor cells of periosteal origin and may therefore possess significant osteogenic potential. The methodologies developed and described in this thesis represent powerful regenerative tools which may someday result in the realization of our …
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Comparative in vitro study of the proliferation and growth behavior of human osteoblast-like cells on various 2D-biomaterials
… the incorporation of human osteoblast-like cells or earlier osteoprogenitor cells into a scaffold followed by the in vitro multiplication and/or differentiation of osteogenic cells before host implantation. The in vitro study of the growth behavior of osteoblasts onto the surface of the …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… that can obstruct healing. Mesenchymal stem cells have great potential to be used as part of a novel therapy for bone and cartilage regeneration. They are a highly regulated, self-renewing population of cells with potent mechanisms to avoid allogeneic rejection, offering significant potential …
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Cell Kinetics of Osteoblast Histogenesis in Evolving Rabbit Secondary Haversian Systems Using a Double Labeling Technique with [³H]-Thymidine and Bromodeoxyuridine
… process, i.e., less differentiated osteogenic cells reside in close proximity to the advancing central blood vessel (CBV) while differentiating osteoblast precursors migrate toward the bone surface and become osteoblasts. Using a double-labeling method with [3 H]-thymidine and bromodeoxyuridine …
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The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications
… for bone tissue engineering involves seeding osteoprogenitor cells within a biomaterial scaffold then culturing this construct in a biodynamic bioreactor. The bioreactor imparts osteoinductive mechanical stimuli on the cells to stimulate the synthesis of an extracellular matrix rich in …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
… differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone marrow stroma following glucocorticoid treatment, Sprague-Dawley rats were administered methylprednisolone for up to six weeks, then …