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Showing 1 to 20 of 57 for “"osteopontin"”.
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The Function and Regulation of Senescent Stromal-Derived Osteopontin
… identified the secreted multifunctional protein osteopontin: OPN) as a critical stromal mediating factor. RNAi-directed reduction of stromal OPN leads to decreased growth of preneoplastic keratinocytes in vitro and in vivo. Furthermore, I have demonstrated the presence of senescent stroma and …
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Expression and Regulation of Osteopontin in the Diabetic Heart
… underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to …
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Einfluss der Osteopontin Defizienz bei Mäusen auf allergische Hautreaktionen vom Spättyp
Osteopontin (OPN) ist ein von Immunzellen sezerniertes, saures Phosphoprotein. In <br>verschiedenen Modellen konnte eine Th1-Zytokinartige Wirkung von OPN nachgewiesen <br>werden. Kürzlich wurde gezeigt, dass OPN während der Sensibilisierungsphase einer <br>Kontaktallergie in der Haut und in den …
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Early-life supplementation of osteopontin supports neurodevelopment and influences exploratory behavior
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… 30% of stroke victims receive medical attention. Osteopontin (OPN), a ubiquitous protein with roles in cell migration, inflammation, and apoptosis, has been shown to confer neuroprotection following ischemic stroke in animal models. In this work, we not only successfully fabricated GNPs with a …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… and CXCL2, and bone marrow macrophage-secreted osteopontin as key drivers of pro-inflammatory environment in the bone marrow and important regulators of tumor growth and survival in bone. </p> <p>Our results revealed that adipocyte-supplied CXCL1 and CXCL2 are significant contributors to …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… secondary to adenosine-dependent expression of osteopontin (OPN). OPN is a protein implicated in a variety of human pathology, but its role in COPD has not been examined. To address this, Ada/Opn -/- mice were generated and endpoints consistent with COPD were examined in parallel with Ada -/- …
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Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers. While OPN is significantly expressed in hepatocellular …
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Corrélation of Plasma Osteopontin Levels and 3D US Imaging with Tumor Response to Neoadjuvant Therapy
… monitoring tumor response: measurement of plasma osteopontin (OPN) levels and three dimensional ultrasound imaging (3D US). Using our laboratory’s in house ELISA, we found that 39% of LABC patients had plasma OPN levels elevated above the normal healthy range of I23ng/ml (Bramwell,20o6). Over …
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Effects of supplemental osteopontin on intestinal development and serum antibody responses to rotavirus vaccination in piglets
… intestinal growth and mucosal immunity include osteopontin (OPN). Osteopontin is a phosphorylated acidic glycoprotein expressed by a number of different immune and non-immune cells and tissues (Sodek et al., 2000). It is also present in body fluids including blood, bile and milk (Sodek et al., …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
Osteopontin (OPN), a glycosylated phosphoprotein found in brain, is reduced in the surviving dopamine-containing neurons in the SN (SN) in Parkinson’s disease (PD). OPN prevents the death of dopaminergic neurons in cell culture and animal models of PD. This effect may be mediated through …
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HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later.
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Effect of Cellular Positional Identity on Bone Regenerative Capacity for Tissue Engineering
… by alkaline phosphatase (ALP) staining, osteopontin (OPN), osteocalcin (OCN) expression and osteoblast-associated gene expression in long term culture. Gene expression of cells was determined by quantitative RT-PCR. Differences in Hoxa gene expression as markers of positional identity …
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Development of biodegradable, biomimetic hydrogels modulating cellular function for guided bone regeneration
… structure of the OPF hydrogels. Finally, osteopontin-derived peptide (ODP) was covalently incorporated to the OPF hydrogels and modulation of MSCs on the peptide-modified hydrogels was investigated. The results showed that OPF-based peptide-modified hydrogels can modulate cell …
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The study of the role of mast cells in malignant pleural effusion
… the thorax by releasing chemokine ligand 2 and osteopontin, respectively. Mast cells were essential for malignant pleural effusion formation, cooperating with tumor cells and the pleural environment to trigger vasoactive and oncotrophic effects upon tumor cell encounter. To achieve this, mast …
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Rarity of kidney stones in South Africa's black population : studies of urinary macromolecules, crystal matrix extract containing osteopontin, and bone turnover markers in urine and serum from black and white subjects as a key to understanding this paradox
… were conducted with commercially available osteopontin. In addition, a comprehensive trial was conducted in which the ingestion of three sodium salts (sodium chloride, sodium bicarbonate and sodium citrate) was investigated for their effects on urinary risk factors of CaOx stone formation …
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Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate
… synthesis, alkaline phosphatase (ALP) activity, osteopontin synthesis and collagen synthesis were determined. Results indicate that culture in the presence of Zr-ACP significantly increased cell proliferation, ALP activity and osteopontin synthesis but not collagen synthesis. To determine the …
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