Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"osteolysis"”.
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The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
… osteoclast differentiation in vitro and osteolysis in vivo. Our work demonstrates that IKKβ is central to osteoclast differentiation and is therefore an important target in therapy for osteoclast-mediated disease.
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
… resorptive disorders to be used here, causes osteolysis through a “vicious cycle”, whereby osteoclasts release growth factors (e.g., TGFβ) stored in the bone, which can cause bone-metastatic tumor cells to secrete pro-osteolytic factors (e.g., PTHrP), resulting in more osteoclast-mediated bone …
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Aseptic loosening around total hip and knee arthroplasty is linked to plasma microRNA
… wear over time. These microparticles cause osteolysis around the prosthesis, which begins to weaken the bony architecture over time, thus leading to loosening of the implant. However, this theory alone does not explain why certain patients have significant amounts of prosthesis wear, but …
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… factors that promote osteoclastogenesis and osteolysis. The PI3K pathway is activated by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast survival and activity in a CSF-1R dependent manner, we hypothesized that inhibition of CSF-1R or …
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is highly expressed in a highly metastatic bone-tropic clone of the human MDA-MB-231-BT (MDA-231-BT) breast cancer cells when compared to parental MDA-MB-231 (MDA-231) cells. Targeted knockdown of …
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Characterization of the Rank Ligand Positive Giant Cell Found in the Interfacial Membrane
Aseptic osteolysis is a major complication to total joint arthroplasty requiring several thousand people a year to have to undergo revisions of their joint prosthesis. The formation of the interfacial membrane has been associated with aseptic osteolysis leading to the failure of all types of total …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… in vivo models for the study of tumour – induced osteolysis were created using adapted organ cultures and intratibial injection techniques respectively. IGF-1 and its receptor are known to play important roles in both bone metabolism and breast cancer. Therefore a study of the effects of IGF-1 …
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In Vivo Wear Performance of Highly-crosslinked Polyethylene in Total Hip Arthroplasty
… cell response, potentially leading to osteolysis and subsequently implant failure. Also, variations in the manufacturing processes of HXLPE across different manufacturers may influence the cross-linking degree of the polymer, thus significantly affecting the in vivo tribological …
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Friction and lubrication behaviour of hip resurfacing metal-on-metal and ZTA ceramic on CFR peek implants with various diameters and clearances. Friction and lubrication behaviour of hip resurfacing Co-Cr-Mo and zirconia toughened alumina ceramic heads against carbon fibre reinforced poly-ether-ether-ketone cups with various diameters and clearances have been investigated using serum-based lubricants.
… between the articulating surfaces leading to osteolysis and implant loosening with revision surgery becoming inevitable in more active patients. Tribology plays an important role in developing the design, minimizing wear and reducing friction of hip joint prostheses in order to improve their …
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Effects of select fluids on the friction of metal-on-polyethylene joint replacement surfaces
… of cytokine responses that ultimately leads to osteolysis and aseptic loosening. Although research in the materials selection and design of TJA components is continually advancing, one of the major intrinsic components that affect the tribological response in joints is overlooked. In particular, …
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Knöcherne Integration und Biokompatibilität eines neuen resorbierbaren Polymers zur Schraubenaugmentation im osteoporotischen Knochen
… observed six months after implantation. Massive osteolysis was seen and in some cases so severe that the screw was loose. The degradation kinetics of the new polymers were unsatifactory, because there was no decrease in the volume of the applied bone cement after six months. There is no …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… as the treatment for disease characterized by osteolysis, to selectively deliver doxorubicin (Doxo) to the bone tissues and substantially to improve their therapeutic efficiency in inhibiting the growth of osteosarcoma in both murine and canine models. More importantly, the developed NCs could …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… are significant contributors to tumor-driven osteolysis in metastatic disease. We showed, that interaction of CXCL1 and CXCL2 with their receptor CXCR2 on osteoclast precursor cells drives osteoclastogenesis in vitro and bone degradation in vivo. Our studies also demonstrated that in addition …
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Morphology and Localisation of Patient Hip Replacement-Derived Debris and Hip Prostheses Materials in Macrophages
… the risk of an adverse reaction, including osteolysis. Macrophages respond to the presence of wear debris and degrade the materials via phagocytosis, resulting in the production of toxic ions capable of migrating to other areas of the body. Both characterisation and localisation of wear …
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Immune system involvement in metal hip implant failure
… debris and consequent immune system mediated osteolysis resulting in peri-prosthetic loosening. To understand the immune system involvement in metal hip implant failure, a cohort of OA patients were recruited with and without an Ultima implant. This study investigated; The Human leukocyte …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… tumour growth, angiogenesis, metastasis and bone osteolysis. Major cellular responses and adaptation to hypoxia are mediated through Hypoxia-Inducible Factor (HIF) signalling. The HIFs are heterodimeric transcription factors that activate the transcription of hundreds of target genes in response …
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Wear and Corrosion Resistance Improvement of CoCrMo alloy by Tantalum Based Coatings
… and corrosion of the metallic ball which causes osteolysis, inflammation, and loosening of the implant components. Coating the metallic femoral head is one of the most promising techniques to reduce the wear of the polyethylene liner and improve the corrosion resistance of the femoral head, which …
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In vitro evaluation of equine bone-marrow derived mesenchymal stromal cells to combat orthopedic biofilm infections
… and tissue destruction, including peri-implant osteolysis and subsequent implant failure and chondromalacia with subsequent osteoarthritis. In horses, the resulting lameness, reduced athletic potential, and poor quality of life may necessitate euthanasia. Equine bone marrow-derived mesenchymal …
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