Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 169 for “"osteogenic"”.
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Use of comparative proteomics to study a novel osteogenic nanotopography
The principal aim of this thesis was to investigate the ability of surface topography in inducing bone cell differentiation for biomedical purposes. In orthopedic research, regeneration of bone defects can be performed in vitro using biomaterials. Third generation biomaterials aim not only to …
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The osteogenic effects of zirconia and titanium surfaces on human osteoblasts
… and biofunctionalization—to enhance late-stage osteogenic outcomes. This work contributes to a better understanding of material-specific effects on osteoblast behavior and provides valuable insights for the design of next-generation implant materials with improved biological and clinical …
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Osteogenic Scaffolds for Enhanced Graft-Bone Integration in Ligament Tissue Engineering
Among the most common knee ligament injuries are those to the anterior cruciate ligament (ACL). Annually, approximately 350,000 people require surgical ACL reconstruction, accounting for more than $6 billion of health-care costs in the United States alone. An injured ACL loses its functions as it …
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Cell seeding and proliferation simulations to plan experiments of multicellular osteogenic systems
… densely packed, cuboidal, mature osteoblasts. Osteogenic differentiation of stem cells can be promoted in vitro via geometry using micropatterned substrates, or via seeding densities that allow for cell spreading. Due to the complexity of biological systems, typically, researchers use patterned …
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Bionanoparticles as Viable Substrates to Promote Osteogenic Differentiation of Bone Marrow Stromal Cells
… the effect of nanotopography on the promotion of osteogenic differentiation of BMSCs. The nanoptopographies were created by coating 2D substrates with turnip yellow mosaic virus (TYMV) and tobacco mosaic virus (TMV) bionanoparticles. TYMV and TMV, both are nanosized plant viruses with spherical …
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
… chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells (hMSC) could be an important tool in the treatment of orthopedic deficiencies such as bone defects. The extent of in vitro human mesenchymal stem cell growth, adhesion, motility and …
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EFFECTS OF OSTEOARTHRITIS AND INFLAMMATION ON MENISCUS CELL RESPONSE TO OSTEOGENIC PROTEIN 1 (OP1)
… Bone Morphogenic Protein (BMP) family member, Osteogenic Protein 1 (OP1/BMP7) in meniscus cells. We have focused on the meniscus, because this tissue is highly susceptable to injuries which often fail to heal and lead to osteoarthritis (OA). OA is driven by molecular inflammation which disrupts …
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The design and numerical analysis of a microfluidicssystem for osteogenic differentiation of mesenchymal stemcells.
… early periods of mes-enchymal stem cells during osteogenic differentiation. Where the glucose/lactate levelsare assesed, including the development of a characteristic profile of the metabolomicand lipidomic factors that could allude to key biomarkers which could be used to assessthe proposed …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… the direct effects of mild heat shock on the osteogenic differentiation of hMSCs while simulating inflammation. Human MSCs isolated from bone marrow were seeded in 2D culture plates and incubated for 1 hour at 39°C once per week during osteogenic differentiation. Alkaline phosphatase activity …
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The Osteogenic Effects of 12 Weeks of Oral Supplementation of Androstenedione in Middle-Aged Men.
<p>Recent evidence suggests that declining bone mineral density (BMD) in males is related to declining circulating estrogens. The majority of endogenous plasma estrogens in males result from peripheral aromatization of plasma androgens. Thus, it was hypothesized that dietary supplementation with an …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
… composite scaffolds to guide chondrogenic and osteogenic differentiation. In an osteochondral defect environment, interactions exist between bone marrow cell populations. Although MSCs have been extensively utilized for their ability to support hematopoietic stem and progenitor cells (HSPCs), …
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In Vitro Regulation of Ptgs2 and Nos3 Expression in Clonal Osteogenic Cells Following Pulsatile Fluid Flow
… endothelial isozyme is mechanically regulated in osteogenic cells. This increase in expression is due to both increased transcription as well as increased stability by the action of ELAVL1.|Murine osteocytes (MLO-Y4) and osteoblasts (2T3) were subjected to pulsatile fluid flow to determine changes …
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Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process
… these cells utilize to differentiate down the osteogenic pathway are still unclear. Specific differences exist between BMSC and ADSC osteogenesis; however more detailed analysis of how the two MSC types differ will be important for enhanced clinical relevance of ADSC. Chapter 1 of this work …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
… that cytokines driving these angiogenic and osteogenic processes, like vascular endothelial growth factor (VEGFA), are critical for bone repair. However, the role that bisphosphonates and osteoblast lineage cells play in modulating these indispensable angiogenic and osteogenic factors in vivo …
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Osteogenic and chondrogenic differentiation of rat bone marrow stromal cells in 3D culture with novel PCL-TCP scaffolds
… this project was to investigate the efficacy of osteogenic and chondrogenic differentiation of rat bone marrow stromal cells (BMSC) in 3D PCL-TCP scaffolds. PCL-TCP scaffolds fabricated by fused deposition modeling (FDM), are honeycombed, highly reproducible bioresorbable 3D structures with a …
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The synergistic effect of pulsed electromagnetic fields and demineralized bone matrix on the osteogenic differentiation of mesenchymal stem cells
… that are osteoconductive, osteoinductive and osteogenic in order to achieve optimal bone healing. Furthermore, electrical stimulation technologies such as pulsed electromagnetic fields (PEMF) have been used to enhance the effectiveness of bone graft materials. PEMP has been shown to have a …
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An in vitro evaluation of tyrosine derived polyarylates and polycarbonate as polymeric scaffold for human mesenchymal stem cells osteogenic differentiation
… grown for 16 days in the presence or absence of osteogenic supplement. Alkaline phosphatase activity, cell number by DNA quantification and the amount of calcium in the extracellular matrix were measured at day 4,8,12 and 16. In addition, osteocalcin assay was performed at day 16. The results …
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