Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"osteoclast differentiation"”.
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Expression of Capn6 During Osteoclast Differentiation In Wild-Type and Hdac4 Knockout Mice
Introduction: The process of osteoclast differentiation consists of a network of complex signaling pathways. Previous studies suggest HDAC proteins play a suppressive role in osteoclast differentiation; however, not much is known about the specific role of HDAC4. Capn6 has been linked to increased …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… stem cells concerned in both osteogenesis and osteoclastogenesis are different, they both originate from the bone marrow, therefore the same primary human bone marrow cells containing the specific stem cell populations required for osteogenesis or osteoclastogenesis were used to establish in …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
As mammals age, osteoblast numbers decrease while osteoclast numbers increase, resulting in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
Increased osteoclast (OC) bone resorption and/or decreased osteoblast (OB) bone formation contribute to bone loss in osteoporosis and rheumatoid arthritis (RA). Findings of the basic and translational research presented in this thesis demonstrate a number of mechanisms by which cytokine-induced …
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The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
… of osteoblasts: bone-building cells) and osteoclasts: boneresorbing cells) determines the state of bone metabolism, and a tip in this balance toward either cell type is detrimental to health. In clinical settings, the most common bone diseases favor increased osteoclast activity and …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled. Although the activation and amplification of …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, and their differentiation is regulated by …
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Sex-specific gene expression and its effect on osteoclast maturation
<p>Osteoclasts lie at the root of abnormal bone loss associated with osteoporosis. Osteoporosis primarily affects women and develops when estrogen, a negative regulator of osteoclast life cycle, plummets with menopause. In addition to the role of estrogen, the existence of inherent differences …
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The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
Osteoclasts are large multinucleated cells that resorb or degrade bone. Over-active osteoclasts result in fragile bones that fracture easily, causing bone degenerative disorders such as osteoporosis. Inhibiting osteoclast activity represents a viable strategy to combat bone degeneration. When the …
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
… via complex coupled actions of bone-resorbing osteoclasts and bone-forming osteoblasts. Loss of coupling between bone formation and bone resorption leads to pathogenesis of bone metabolic diseases including osteoporosis or osteopetrosis. Defects in osteoclast activity, whether increased …
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The Role of Claudins in Bone Metabolism
… of bone forming osteoblasts and bone resorbing osteoclasts. To this end, recent evidence suggests a significant role for caudins (Cldns), which comprise a major group of tight junction proteins, in bone biology and development. This notion is based on our previous studies which demonstrated that …
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
… would benefit a wide variety of patients. Osteoclasts resorb mineral in vivo and we hypothesized that a cell therapy based on inducible osteoclast differentiation could be used as a cell therapy to treat EC and HO. The RANK/RANKL pathway is a critical step in osteoclast differentiation and …
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Novel Molecules that Regulate Bone Formation and Bone Resorption
… that DOR is an important regulator of osteoblast differentiation. In addition, a single nucleotide polymorphism (SNP) in the promoter of human DOR gene associated with plasma levels of the bone formation marker, osteocalcin, in men. Targeted disruption of the tight junction protein, Cldn-18, in …
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Kinetics of notch signaling during osteoclastogenesis
… pathway known to regulate cell proliferation, differentiation and survival in many cell types including the differentiation of osteoclasts from bone marrow macrophages (BMMs). Osteoclastogenesis is initiated in BMMs by receptor activator of nuclear factor kappa-B ligand (RANKL) in the presence …
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Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences From Serum Biomarkers in Young Women
… Serum concentrations of OPG, a suppressor of osteoclastogenesis, increased with high-load muscular strength training that led to local increases in muscle strength and BMD. These adaptations may represent an exercise-mediated suppression of osteoclast differentiation and activity. The central …
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… as innate immune response, cell survival and osteoclast differentiation. Upon activation, it mediates activation of IKK/NF-κB and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate …
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Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… to hematopoietic Stat3-deficient mice. Since osteoclast and inflammatory cytokine genes are NFκB targets, these observations indicate a possible deregulation of NFκB signaling in both mice and humans with STAT3-deficiency. Here, we sought to examine the role of STAT3 in the regulation of …
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… uniquely expressed RANKL, a key regulator of osteoclast differentiation and normal B-cell development. FLT3 inhibition decreased RANKL expression, suggesting at least partial dependence on trFLT3 signaling. RANKL-expressing TM B-ALLs decreased trabecular bone density after adoptive transfer to …
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