Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"osteochondral defects"”.
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… When utilized in the repair of rabbit osteochondral defects, OPF scaffolds were shown to undergo biocompatible degradation and to support healthy tissue in-growth. However, the incorporated TGF-beta1 was not shown to greatly influence tissue repair. Accordingly, further investigations …
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Evaluation of Two Techniques of Cancellous Bone Grafting of Experimental Subchondral Bone Cysts in the Medial Femoral Condyles of Horses
Cylindric (10 mm diameter X 15 mm deep) osteochondral defects were created in the medial femoral condyles of 5 horses to mimic clinical cases of subchondral bone cysts after debridement. The defects were created with either a standard square ended drill bit or a compaction drill bit. The compaction …
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Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
… caused by bone, cartilage, and osteochoondral defects present special challenges to tissue engineers. An ability to fabricate these tissues in vitro will eliminate clinical complications caused by current techniques used in graft reconstruction. These complications include long-term failure of …
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Smart Materials for Cartilage and Bone Tissue Engineering
… it is challenging for regeneration of cartilage defects. Furthermore, because of the distinct structure of cartilage and subchondral bone, stem cell-alone or biomaterial-alone based strategy might not be able to simultaneously fulfil the requirement for regeneration of cartilage and subchondral …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
Damage to synovial joints results in osteochondral defects that only heal with inferior fibrous repair tissue. Since mesenchymal stem cells (MSCs) play a vital role in the natural development, maintenance, and repair of cartilage and bone, tissue engineering strategies to enhance functional …
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Orienting structure to serve medical functions
… orthopedic implants for treatment of osteochondral defects. After creating the bonding between hydrogel and metal base, the thesis then introduces the work of a synthetic hydrogel. The goal of the work is to increase the mechanical strength of the hydrogel, which further increases the …
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Management of cartilage deficiency by applying extracellular matrix membrane on bone marrow stimulation technique and evaluating the quality of repaired cartilage
… in repair of large full-thickness cartilage defects was investigated in this study. Rabbits were divided into four groups: the defect remained untreated as a negative control; performance of BMS only (BMS group); BMS followed by supplementation of autologous bone marrow buffy coat (Buffy coat …
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Retrograde Ausdrückversuche am bovinen Femurkondylus zur Testung der Implantatverankerung spongiöser Konstrukte
… um durch tissue engineering hergestellte osteochondrale Konstruke zu implantieren. <br>Die Arbeit ist Teil einer Reihe von Untersuchungen zur Entwicklung einer neuen Therapiemethode zur Behandlung osteochondraler Gelenkknorpeldefekte. <br>Das Verfahren der Wahl ist die sogenannte Press-fit …