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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"osteochondral"”.
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Exogenous mesenchymal stromal cells in osteochondral repair
… human bone marrow derived MSCs into a mouse knee osteochondral injury model were investigated in young C57Bl/6 mice, aged C57Bl/6 mice and GNL3 heterozygote mice. MSC treatment was associated with improved osteochondral tissue repair in young C57Bl/6 mice but this was more limited in aged C57BL/6 …
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Osteochondral properties and relationships in the synovial joint
… and novel equipment for loading opposing osteochondral surfaces and to quantify intratissue cartilage strains within the loaded samples, and (6) to determine any regional relationships between the cartilage strains and underlying subchondral bone plate thickness and bone mineral density. …
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Osteochondral allograft preservation in a serum-free chemically-defined media
… than repair the tissue have been developed. Osteochondral allografts (OCAs) allow the transplantation of whole cartilage tissue into a defect with viable cells, or chondrocytes that will maintain the cartilage matrix. Fresh OCAs have demonstrated greater than 75% clinical success in the …
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The role of the bone marrow niche and G-CSF in osteochondral repair
… pain and maintain joint function. Procedures for osteochondral repair, such as drilling or microfracture of the subchondral bone, are thought to restore cartilage by delivering bone marrow cells to the defect site. However, the specific identity or contribution of these cells to the repair process …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the release of growth factors from acellular hydrogel composites containing gelatin microparticles (GMPs) to stimulate the repair of cartilage tissue in an in vivo osteochondral defect model. Transforming …
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Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
… (Aim 1), articular cartilage (Aim 2), and osteochondral tissue (Aim 3). As a result, the assembly of bone mineral structure was accomplished by regulating nucleation, mineral-binding protein deposition sites, and affinity for mineral binding. Native-like articular cartilage with physiologic …
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A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… (PCL) scaffold to create a novel osteochondral construct. The self-assembling peptide hydrogel has been shown to provide an environment that maintains chondrocyte phenotype and viability. Furthermore, the 3D scaffold fosters extracellular matrix production and chondrocyte division. …
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The healing of an autogenous osteochondral graft and a full thickness cartilage defect in the canine talus: compared by functional, radiographic and histological assessment
… surface of the lesion was repaired using an osteochondral graft obtained from the ipsilateral manus. The graft (Digit I, 1st phalanx, distal articular surface and diaphysis) was contoured to obtain a press fit in the drilled talar recipient site. In six dogs the lesion was not treated and …
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Early Osteoarthritis: A multi-scale structural and mechanical investigation
… in carbonate-substituted hydroxyapatite at the osteochondral junction. Following on from this work, the changes in mechanical properties of the calcified tissues with early OA were more broadly explored using three scales of mechanical testing, namely macroscopic three point bending, …
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Utility of inbreeding coefficient and sire as predictors for osteochondrosis risk in Standardbred horses
… yearlings fluoroscopically screened for osteochondral fragments. Controls (n = 545) were defined as horses that had no osteochondral fragments in any joint. Two groups of cases were defined; those with ostechondrosis dissecans (OCD) of the hock (n = 198) and those with plantar …
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The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… Therefore, to enhance the outcome of this osteochondral repair approach, it is necessary to understand the biological mechanisms involved in the healing process following microfracture. Osteochondral repair is a complex interplay of cellular interactions and changing extracellular matrix …
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A Method to Improve Cartilage Integration
… chondrocyte death (ZCD) that is generated upon osteochondral graft harvest, which can extend up to 400 μm into the cartilaginous portion of the graft. In order for cartilage integration to occur, chondrocytes must be present at the graft periphery; however chondrocyte migration through the ZCD …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… When utilized in the repair of rabbit osteochondral defects, OPF scaffolds were shown to undergo biocompatible degradation and to support healthy tissue in-growth. However, the incorporated TGF-beta1 was not shown to greatly influence tissue repair. Accordingly, further investigations …
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Smart Materials for Cartilage and Bone Tissue Engineering
… in vivo by the thermosensitive hydrogel, osteochondral defects were fully regenerated, which demonstrated that the thermosensitive hydrogel might be a promised vehicle for the delivery of stem cells and facilitate the osteochondral regeneration. Moreover, those autologous …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
Damage to synovial joints results in osteochondral defects that only heal with inferior fibrous repair tissue. Since mesenchymal stem cells (MSCs) play a vital role in the natural development, maintenance, and repair of cartilage and bone, tissue engineering strategies to enhance functional …
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Knee injuries and their consequences – the impact of impact
… of injury, traumatic bone marrow lesions and osteochondral fractures, located predominantly in the lateral tibiofemoral compartment, are commonly associated with an ACL injury. The subsequent risk of OA may be closely associated with the knee injury mechanism and the panorama of injuries in …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
… human ankle cartilage and bone in a novel osteochondral PTOA model that incorporates disease-relevant tissue crosstalk. Across seven human donors, proteomic analysis of culture media and cartilage tissue revealed that catabolic disease effects such as matrix breakdown and sGAG loss were …
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Management of cartilage deficiency by applying extracellular matrix membrane on bone marrow stimulation technique and evaluating the quality of repaired cartilage
… coat group); transplantation of autologous osteochondral transplantation (AOTS) as a positive control. Repair of cartilage defects in the Buffy coat group in a rabbit model was more effective than BMS alone and similar to AOTS. Gross findings, histological analysis, histological scoring, …
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The heterogeneous biochemical modification of porous collagen scaffolds for tissue engineering applications
… . This technique was used to model the osteochondral interface.
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Development of bi-layer mineralized bone and cartilage regeneration template
… today. This dual combination is termed a layered osteochondral scaffold.
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