Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"ospC"”.
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OspC in the pathogenesis of Borrelia burgdorferi
… lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The …
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Analysis of the role of outer surface protein C (OspC) in Borrelia burgdorferi pathogenesis
… the expression of outer surface protein C (OspC). OspC is a surface exposed lipoprotein encoded on circular plasmid 26 that forms homodimers on the bacterial surface and has distinct conserved and variable portions of sequence. When ospC is deleted, the spirochetes are unable to cause …
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Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine
… trials for human use. Outer surface protein C (OspC) is an alternative in the same line because it induces a significant antibody response and provides strain-specific protection after the tick challenge. However, due to OspC heterogeneity, there are limitations to using OspC as a broad-spectrum …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it is also a target for the mammalian acquired immune response, and thus, OspC is repressed soon after B. burgdorferi establishes infection. It …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it is also a target for the mammalian acquired immune response, and thus, OspC is repressed soon after B. burgdorferi establishes infection. It …
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Geographic distributions and vertebrate host specificity of genetic lineages of Borrelia burgdorferi
… the United States. The outer surface protein C (ospC) gene of B. burgdorferi exhibits substantial genetic variation across the pathogen’s distribution and plays a critical role in virulence and transmission in vertebrate hosts. In fact, B. burgdorferi infections that disseminate across host …
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Development of Oral Vaccines Against Lyme Disease
… E. coli that express B. burgdorferi’s OspC type K, OspB, BBK32, and Ixodes scapularis Salp15 and Salp25. Only oral immunization with live E. coli expressing OspC K induced systemic immune responses characterized by high levels of OspC K-specific IgG antibodies in sera as well as IgA …
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Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
… structurally and functionally distinct dimeric OspC-Vsp family lipoproteins and identified their requirements for surface localization. As for OspA, tether sequences influence the localization of OspC-Vsp lipoproteins within the envelope. Interestingly, OspC-Vsp lipoproteins appear to be …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… major outer surface proteins OspC and OspA. Temperature is one of the key environmental signals controlling RpoS, but the molecular mechanism by which the signal is transduced remains unknown. DsrABb post-transcriptionally regulates the alternative sigma factor RpoS in response …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… major outer surface proteins OspC and OspA. Temperature is one of the key environmental signals controlling RpoS, but the molecular mechanism by which the signal is transduced remains unknown. DsrABb post-transcriptionally regulates the alternative sigma factor RpoS in response …
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Effect of Site-specific Changes in the Regulatory Functions of BosR
… strain but had dramatically lower levels of OspC. Replacement of the conserved histidine at position 111 with an alanine resulted in not only a reduction in the levels of BosR but also in the levels of OspC. There was no changes in the levels of bb0646 which is co-transcribed with bosR …
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Regulation of outer surface lipoprotein A in the Lyme disease spirochete Borrelia burgdorferi
… protein A (OspA) and outer surface protein C (OspC), are reciprocally regulated throughout the B. burgdorferi lifecycle. Very little is known about the regulation of OspA. These studies elucidate the regulatory mechanisms controlling the expression of OspA. Various truncations of the ospA …
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Elektronenmikroskopische Untersuchungen an Borrelien
… heterogenen Oberflächenproteine OspA und OspC konnte durch Immun-Gold-Markierungen mit Hilfe typspezifischer und breitreaktiver monoklonaler Antikörper nachgewiesen werden. Typspezifische und konservierte Epitope beider Proteine befinden sich auf der Oberfläche der äußeren Membran. Die …
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
… the BBB and that the outer surface protein C (OspC) controlled by this pathway plays a vital role in crossing the BBB. We found that B. burgdorferi is detectable in the brains of middle-aged mice but not in younger mice and triggers host immune response, resulting in elevated levels of …
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Coping with stress: How Reactive Oxygen and Nitrogen Species alter the transcriptional landscape of the Lyme disease spirochete Borrelia burgdorferi
… associated with mammalian infection such as ospC, dbpA, and bba66) were downregulated in response to sublethal concentrations of H2O2 (25 µM) and sper/NO (0.625 mM) coupled with a pH shift—the expression patterns were less defined in the absence of a pH shift. Additionally, we observed …