Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"oseltamivir"”.
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Two enantiodivergent syntheses of balanol and the chemoenzymatic synthesis of oseltamivir
… benzoate was employed in a formal synthesis of oseltamivir. Finally, several synthetic approaches to oseltamivir and its analogs are presented, each proceeding through a different vinyl aziridine derived from bromobenzene and ethyl benzoate.
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Repurposing Oseltamivir, a Commonly Prescribed Influenza Antiviral, for the Prevention of Noise- and Cisplatin-Induced Hearing Loss
… death in an inner ear cell line, and identified oseltamivir phosphate (brand name Tamiflu), a common influenza antiviral drug, as a top candidate. Oseltamivir phosphate was found to be otoprotective by oral delivery in multiple established cisplatin and noise exposure mouse models. The drug …
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The Molecular Basis of Fitness and Transmissibility of Neuraminidase Inhibitor Resistant Influenza A Viruses
<p>Neuraminidase (NA) inhibitors including oral oseltamivir and inhaled zanamivir are among the first line of defense against influenza virus infection. Development of resistance to NA inhibitors is a huge drawback for limited options for the control of influenza. During the first decade of NA …
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NEU Insights and Development of Potential Therapeutics for Pulmonary Fibrosis
… small molecule sialidase inhibitors, DANA and oseltamivir (Tamiflu), work well on viral and mouse sialidases, but relatively poorly on human sialidases. In the bleomycin-induced pulmonary fibrosis mouse model, daily intraperitoneal injections of either DANA or oseltamivir at 10 mg / kg, …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
… of NMBR (BIM‑23127), MMP9 (MMP9i), or Neu1 (oseltamivir phosphate), indicating dependence on the GPCR‑MMP9‑Neu1 signaling platform. Immunofluorescence co‑localization analysis revealed strong spatial proximity between A₂AR and Neu1 on the cell surface (Pearson’s r = 0.8968), supporting the …
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Virus elimination from Actinidia germplasm
… amantadine hydrochloride, 5-azacytidine, oseltamivir, ribavirin, 2-thiouracil, and vidarabine) against AMV, ASGV, AVX, CLBV-a, and CMV in N. occidentalis shoot tip cultures cultures was determined. Only ribavirin (20mg/L) and ribavirin (10mg/L) combined with quercetin (10mg/L) had a …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… of NMBR (BIM-23127), MMP9 (MMP9-i), and Neu1 (oseltamivir phosphate; OP), suggesting pathway specificity. Colocalization analyses further revealed that CB2 receptors form heteromeric complexes with Neu1 in naïve, unstimulated PANC-1 cells, indicating a molecular interaction at the cell surface. …
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Applying at scale genomic and phenotypic approaches to study pathogens linked to nosocomial transmission and disease
… shown the protective effect of the antiviral oseltamivir in multivariable analyses, and how rates of hospital acquired infection and mortality have fallen in response to multidisciplinary interventions over three winters. During the COVID-19 pandemic, real-time genomic-epidemiology analyses …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
… including neuraminidase inhibitors such as oseltamivir and the newer polymerase acidic endonuclease inhibitor, baloxavir marboxil. It identifies populations most vulnerable to influenza-related complications and reviews the existing literature on the effectiveness and safety of antiviral …
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Mechanisms and measurements of sialidase in pneumonia
… from most potent to least potent in the order of Oseltamivir, DANA, Zanamivir and Peramivir. Two in-silico methods were used to verify the experimental results: molecular modelling and molecular docking. Molecular modelling was used to calculate the free energy of the reaction between NanA and …
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Ecology of virulence genes in the human pathogen Streptococcus pneumoniae.
… and secondary pathogen. One of these inhibitors, Oseltamivir, was found to have potential in treating secondary pneumococcal pneumonia, which may help decrease the significant burden of this disease, as well as reducing the over-reliance on antibiotics for treating pneumococcal diseases. …
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Exploring In Vitro and In Vivo Pharmacology of Echinacea Purpurea (L.) Moench
… non-inferiority to the gold-standard therapy Oseltamivir in this indication. Comparable recovery rates were observed for virologically confirmed influenza infections, demonstrating clinical efficacy in the treatment of viral respiratory infections. Another large clinical study investigated EF …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… shaping γδ T cell immunity. Lastly, a cohort of oseltamivir-treated adults with severe influenza infection were utilized to address 3 questions: 1) What is the relationship between patient risk and severity scores throughout severe influenza infection? 2) What immunological features underlay …