Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 171 for “"orthotopic"”.
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A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
… goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… and increasing tumor oxygenation in an Rh30 orthotopic rhabdomyosarcoma xenograft model. However, the effects of BEV on the pharmacokinetics of TPT and the antitumor activity of TPT have not been evaluated. This study aimed to investigate the effect of BEV on TPT systemic and tumoral …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… model by subcutaneous xenograft and orthotopic lung implantation of NSCLC adenocarcinoma cells (A549) that were genetically modified with the human sodium iodide symporter gene (hNIS; SLC5A5) for the purpose of tumor imaging. Lung tumor growth was quantified using single-photon …
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Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters
Orthotopic liver transplantation is the treatment of choice for many patients with end-stage liver disease. Despite advances in immunosuppression, acute rejection remains common (up to 70%) and results in significant patient morbidity. It is frequently difficult to distinguish abnormal liver …
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Orthotopic liver metastasis mouse models of mismatch repair-proficient colorectal cancer recapitulate clinical inefficacy of immune checkpoint blockade
… show that when pMMR CRC cell lines are implanted orthotopically in the liver as liver metastasis, the resultant liver metastases are unresponsive to ICB, which recapitulates the clinical reality that patients with pMMR metastatic CRC do not respond to ICB treatment. We further show that when …
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Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… this hypothesis in mouse preclinical models of orthotopic, advanced (metastatic) NSCLC. Our results indicate that all treatments (with the exception of MK-2206, which caused lethal glucose intolerance), significantly improved the survival of mice compared to controls. The expression levels of …
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The Role of Socioeconomic Status and Race/Ethnicity in Orthotopic Liver Transplantation Outcomes in U.S. Adults Ages 50 and Older, 2002-2012
Orthotopic liver transplantation (OLT) currently represents a life-saving procedure used to extend and improve the quality of life for those with End-Stage Liver Disease (ESLD). However, this procedure, the gold standard of treatment for ESLD, is not readily accessible to all populations. Racial …
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Vergleichende Etablierung und Charakterisierung eines orthotopen Kolonkarzinom-Xenograft-Modells
… and consisted of subcutaneous cell injection, orthotopic cell injection into the cecal wall and orthotopic fixation of a tumor fragment onto the cecum. The subcutaneous experiment took 41 days; the orthotopic animal experiments were equally divided into three points of necropsy each two weeks …
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The development of a system of 24 hours preservation of the heart for transplantation
… when assessed by either functional testing or orthotopic transplantation. (3) A method of in vitro testing of hearts was developed that correlated with results from orthotopic transplantation. (4) A technique of cardiac autotransplantation in baboons was perfected. (5) The high release of …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… to be delivered to brain tumors in a relevant orthotopic system. The goal of this study was to determine the kinetics and mechanism of death induced by proteasome inhibitors in GBM and to compare the ability of BTZ and MRZ to cause proteasome inhibition in orthotopic brain tumors in order to …
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The Impact of Radiation on Glioblastoma Evolution
… on glioma stem-like cell (GSC) initiated orthotopic xenografts, and by assessing radioresistance with a reirradiation protocol. To determine the impact of ITH on intrinsic radiosensitivity, we performed whole-exome sequencing (WES) of multiple tumour fragments and corresponding …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… <p><strong>Experimental Design: </strong>Orthotopic murine models of ovarian and uterine cancer were utilized to study the effect of MSC2363318A on survival and regression. Moreover, <em>in vitro</em> experiments (MTT, Western blot analysis, plasmid transfection, and reverse phase protein …
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… (TF) <em>Zeb1</em> (Zeb1<sup>cKO</sup>) and orthotopic models with conditional deletion of the EMT TFs <em>Snail</em> and <em>Twist</em> (ST<sup>cKO</sup>) to evaluate the role of EMT transcription factors in the efficacy of MRTX1133. We further probed the efficacy of Kras inhibition and …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… systemic targeting to the normal brain and to an orthotopic human glioma model. We demonstrate that this peptide functionally mimics iron through an allosteric mechanism and that a non-canonical association of (i) transferrin, (ii) the iron-mimic ligand motif, and (iii) transferrin receptor …
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
… <p><strong>Experimental Design: </strong>Murine orthotopic models of ovarian cancer (OVCAR5 and SKOV3ip1) were used to study the biological effects of L-Grb2 on tumor growth. <em>In vitro</em> experiments (cell viability assay, Western blot analysis, siRNA transfection, and reverse phase protein …
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… immune system interaction in a murine model of orthotopic pleural mesothelioma.
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Fasting Reduces Intestinal Radiotoxicity Enabling Dose-Escalated Radiotherapy For Pancreatic Cancer
… maneuver in cancer therapy, we used an orthotopic model of pancreatic cancer using KPC tumor cells syngeneic to C57BL/6. Here, we show that fasting-mediated intestinal protection enabled dose escalated SBRT for treatment of these orthotopic tumors. RT with fasting-mediated …
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