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Showing 1 to 6 of 6 for “"orthopoxvirus"”.
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode numerous immunomodulatory genes, including two ER-resident MHCI saboteurs: CPXV012 and CPXV203). CPXV012 inhibits peptide loading of MHCI within the peptide-loading …
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Contribution Of Non-Classical Antigen Presentation To Cd4+ T Cells During Orthopoxvirus Infection
CD4+ T cells play critical roles in host defense during viral infection, yet questions remain regarding the mechanisms for activation of these cells. The critical initiating signal for CD4+ T cell activation is a productive interaction between the T cell receptor and an antigenic peptide in complex …
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Molecular and evolutionary analysis of a gene conserved in most Orthopoxviruses
… of vaccinia virus, Dairen. A number of other Orthopoxviruses were found to contain this ORF, strengthening confidence in its presence in an ancestral Orthopoxvirus. The equivalent DNA sequence was determined for a number of monkeypox virus strains from West and Central Africa. The Denmark …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… virus (VV) is the prototypical member of the orthopoxvirus genus of the Poxviridae family, and is currently being evaluated as a vector for vaccine development and cancer cell-targeting therapy. Despite the importance of studying poxvirus effects on the human immune system, reports of the …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
… virus (VACV) is the most intensively studied orthopoxvirus and acts as an excellent model to investigate host-pathogen interactions. VACV encodes about 200 proteins, many of which modulate the immune response. This study focusses on two of these: C16 and C4, that share 43.7 % amino acid …
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
<p>The orthopoxviridae are large, complex DNA viruses with important historical and clinical significance. Members of this genus encode numerous proteins known to subvert the immune response to infection, providing a useful system to probe required host responses for resistance and survival. …