Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"orthology"”.
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Domain-based approaches to understanding phylogeny and orthology
… used to help the identification of function and orthology. Therefore, domain-based approaches are proved to be useful in many areas of proteome research, including functional annotation, evolutionary illustration, and protein-protein network construction.
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Probabilistic framework for genome-wide phylogeny and ortholog determination
… that is designed specifically for genome-wide orthology determination. Unlike any other method, SINDIR exploits the known evolutionary history of a set of species to infer the history of their genes. This is done by learning a probabilistic model of evolution from a trusted set of unambiguous …
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Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
… viral infection of eukaryotic cells. I then used orthology to explore the conservation of residues linked to protein acetylation and identify a link with lifespan in warm-blooded vertebrates. In conclusion, I have used orthology to further the understanding of human mitochondrial proteome history …
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Phylogenomics of vertebrate serpins
… of fishes and the other vertebrates. The orthology assessment indicates that all vertebrates are equipped with a subset of strongly conserved serpins with functions that can be clearly correlated with basic vertebrate-specific physiology. None of serpin genes from C. intestinalis shares a …
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Bioinformatic identification and characterization of cytokinetic regulators in Mtb
… SulA. Bioinformatic-based assessments of orthology revealed a differential lineage than anticipated for the proteins encoded by both open reading frames (ORFs). We describe these two novel regulators in Mtb here for the first time. It was found that Rv1708 lacks regions vital for MinD …
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Molecular investigations of gene families encoding foldase enzymes in wheat
… molecular markers for these genes. Further, orthology between the PDI loci in wheat and the esp2 locus in rice, which has been associated with irregular storage protein deposition, is described.
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A deeper look into the morphology and receptors found in the tick (Acari: Ixodidae) chemoperception structure, the Haller's organ
… receptor type. The phylogenetic trees show the orthology between the tick ionotropic and gustatory receptors and the described insect chemoreceptors. There were two I. scapularis IRs expressed in the forelegs of these ticks and five GRs of interest. This research aids in providing an increase in …
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Comparison of orthologs across multiple species by various strategies
… to be inferred. Furthermore, evolutionary orthology does not necessarily have a strict correspondence to function similarity. Kruppel type zinc finger genes are important transcription factor families in eukaryotic species. Important as it is, the evolution of this zinc finger family is not …
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Web servers, databases, and algorithms for the analysis of protein interaction networks
… IsoBase, that provides network alignments and orthology mappings for the most commonly studied eukaryotic model organisms: Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae.
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Homeobox gene and microRNA duplication in Chelicerata
… and further tandem duplications. This family has orthology to the insect and nematode miRNAs that are involved in the maternal to zygotic transition (MZT). A subset of Pt-mir-3791 paralogs were also predicted to be involved in the MZT in the spider, possible indicating a more ancestral role of …
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The role of SENSITIVE TO FREEZING6 in plant tolerance to stress
… mutant led to complementation, demonstrating orthology. Rice is a freezing-intolerant species, and therefore the presence of a functional SFR6 orthologue in rice capable of restoring Arabidopsis CBF function suggests that OsSFR6 may play a role in chilling tolerance in rice analogous to that …
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Evolutionary conservation of host responses to arbuscular mycorrhizal symbiosis in liverworts
… stages of symbiosis development. Gene orthology inference and comparative analysis of M. paleacea to two AMS angiosperm models -Medicago truncatula and Oryza sativa- revealed a deep conservation of transcriptional responses to AMS across distantly related land plants. In parallel, …
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The genome of Euglena gracilis: Annotation, function and expression
… with the trypanosomatids in terms of orthology, paralogy, relatedness and complexity. Several biological systems such as nuclear architecture (e.g. chromosome segregation, nuclear pore complex, nuclear lamins), protein trafficking, translation, surface, consist of conserved and …
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Effects of iso-alpha-acids on rumen fermentation and comparison of microbial populations between rumens and continuous culture fermenters
… were made by matching taxonomic data to KEGG Orthology terms using PICRUSt software, and analyzed based on sample type. Community profile did not differ (P > 0.10) between cows in either rumen or inoculum samples, but was different (P < 0.05) in fermenter samples. Microbial community within …
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In silico prediction of host-pathogen protein - protein interactions in the malaria parasite, Plasmodium falciparum
… interaction predictions are based on orthology, these interactions are then analysed to identify potential drug targets. This could potentially aid researchers in their continuous battle against malaria and the larger scale battle against pathogen evolution. To predict in vitro …
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Towards an Understanding of Genetic Control of Processing Quality Traits in Blackcurrant (<i>Ribes nigrum</i> L.)
… developed approach for functional gene orthology annotation (genes with similar functions) can also be utilised for several other (~200) traits analysed in this study and can provide a functional systems biology platform for other woody perennial species with no reference …
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The Major Histocompatibility Complex in Rabbits
… annotated. Phylogenetic analyses confirmed the orthology between rabbit, human, and mice MHC-II genes, indicating a simple MHC-II system where all the major genes except Orcu-DRB are present in a single copy. Specifically, we found five Orcu-DRB paralogs where -DRB1, -DRB2, and -DRB3 possessed …