Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 174 for “"ortholog"”.
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Characterization of the Drosophila Egfl7/8 ortholog during oogenesis
During animal development precise coordination and regulation of cell proliferation, differentiation and cell death is required for proper tissue organization. This is achieved through specific cell communication by intercellular signals. Cell death, for example, is a mechanism utilized by …
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Probabilistic framework for genome-wide phylogeny and ortholog determination
… requires the ability to distinguish between orthologous and paralogous regions. Current approaches to ortholog identification work adequately for pairs of species but are ineffective for multiple complete genomes. This thesis presents a new phylogenetic reconstruction method, SINDIR, that is …
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
… characterization of two Leishmania major-encoded orthologs of the pro-inflammatory pleiotropic cytokine, macrophage migration inhibitory factor (MIF). These two MIF-like sequences show 22% sequence identity when aligned with human MIF, and are most likely the result of gene duplication. The …
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Isolierung, evolutive Einordnung und funktionelle Charakterisierung von Knopfkopf, einem buttonhead-Ortholog in der Maus
Isolierung des Sp1-verwandten Transkriptionsfaktors Knopfkopf mittels eines PCR-basierten Homologie-Screens in der Maus. Das Gen Knopfkopf wurde anschließend hinsichtlich der evolutiven Verwandtschaftsbeziehungen zum Drosophila-Gen buttonhead eingeordnet. Eine funktionelle Charakterisierung …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… has only one APP family member: APL-1, an ortholog of APP with the functional domains conserved. The presence of a single <em>APP</em> gene, along with the genetic tractability and ease of using the worm, make <em>C. elegans </em>an excellent model system in which to explore …
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The role of BNIP3/NIX ortholog in neuronal physiology in C. elegans models of Alzheimer’s disease
Η νόσος Alzheimer (Alzheimer’s disease, AD) χαρακτηρίζεται από προοδευτική διαταραχή των μηχανισμών ποιοτικού ελέγχου των μιτοχονδρίων, η οποία οδηγεί σε μιτοχονδριακή δυσλειτουργία, συναπτική ανεπάρκεια και, τελικά, νευροεκφύλιση. Η μιτοφαγία, δηλαδή η εκλεκτική αυτοφαγική απομάκρυνση των …
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Isolierung, Sequenzierung und Charakterisierung der genomischen Region von Frunx2, dem Fugu-rubripes-Ortholog des humanen RUNX2-Gens
… hier identifizierten und charakterierten Fugu-Ortholog des humanen RUNX2-Gens untersucht. Sowohl die Aminosäuresequenz als auch die genomische Organisation von Frunx2 sind in hohem Maße identisch mit der des humanen RUNX2, insbesondere scheint auch Fugu über zwei verschiedene aminoterminale …
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The PI5P 4-kinase ortholog PPK-2 of Caenorhabditis elegans acts in synaptic transmission and neuronal membrane trafficking
… exprimierte PIP-Kinase PPK-2 dar. PPK-2 ist ortholog zu den PI5P 4-Kinasen in Säugetieren. Der RNAi-knock-down von ppk-2 führte zu einer verminderten Ausschüttung des Neurotransmitters Acetylcholin an Synapsen. Im Gegensatz dazu zeigte die Charakterisierung von zwei Mutantenstämmen mit …
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Cloning and Analysis of a Honey Bee (Apis Mellifera) Period Gene Ortholog and Honey Bee Division of Labor
1Winston, M. L. (1987) The Biology of the Honey Bee. Harvard University Press, Cambridge, MA. 2Moore, D., J. E. Angel, I. M. Cheeseman, S. E. Fahrbach, and G. E. Robinson. (1998) Behav. Ecol. Sociobiol. 43: 147--160. 3Hall, J. C. (1995). TINS 18: 230--240.
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… have very similar properties to its human orthologue. Mouse Pkhd1 extends over approximately 500 kb of genomic DNA and includes a minimum of 68 exons. The longest ORF encodes the 4059-amino acid protein polyductin, predicted to have multiple IPTs and PbH1 repeats and a single membrane …
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Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human [alpha subscript 2]-HS glycoprotein
… we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.
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Characterization of the Whale Shark (Rhincodon Typus) Melanocortin-2 Receptor
… bony vertebrates, the melanocortin-2 receptor ortholog is unique among the family of five melanocortin receptors on the basis that it is dependent on its accessory protein, MRAP1, for trafficking and activation, and is selective for activation by ACTH alone. Previous studies on the MC2R …
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Genomic Conservation of the Outer Hair Cell Motility Protein, Prestin in the Monotreme: Ornithorhyncus anatinus (Platypus)
… birds and reptiles The presence of a prestin ortholog in a highly divergent mammal such as the Omithorhynchus anatinus (platypus) would indicate the preservation of function The absence of a prestin ortholog would allow for comparisons among the genomes, to identify how and when prestin …
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A C. elegans histone methyltransferase promotes spermatocyte gene expression, spermatid production and fertility
… that the germline-expressed C. elegans ortholog of mammalian PRDM9, SET-1 7, promotes fertility through gene regulation in primary spermatocytes. SET-17 drives transcription of spermatocyte-specific genes from four genomic clusters to promote spermatid production. SET-1 7 is concentrated …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… work demonstrates the importance of the DAF-12 ortholog in H. glycines for regulating hatching and introduces the the first well-defined molecular target for controlling the spread of this important pathogen. Additionally, an ortholog with significant sequence and likely functional similarity is …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… work demonstrates the importance of the DAF-12 ortholog in H. glycines for regulating hatching and introduces the the first well-defined molecular target for controlling the spread of this important pathogen. Additionally, an ortholog with significant sequence and likely functional similarity is …
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Regulation of the periplasmic stress responses in E. coli and P. aeruginosa
… in the bacterium Escherichia coli and the orthologous pathway in the bacterium Pseudomonas aeruginosa. These pathways sense stress in the periplasm and relay the signal into the cytoplasm by a series of proteolytic cleavages of a transmembrane regulatory protein. In E. coli, I have …
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IDENTIFICATION AND CHARACTERIZATIONS OF PATHOGENICITY GENES IN FUSARIUM VIRGULIFORME, THE CAUSAL AGENT OF SOYBEAN SUDDEN DEATH SYNDROME (SDS)
… (a sucrose non-fermenting protein kinase 1 ortholog), the Fvstr1 gene (a striatin protein ortholog) were functionally characterized through a gene knock-out strategy. Targeted disruption of the FvSNF1 locus in wild type F. virguliforme strain reduced virulence significantly on soybean and …
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SIK-mediated regulation of feeding behavior and fat metabolism in Caenorhabditis elegans
… mutation of the sole Salt-Inducible Kinase (SIK) ortholog (kin-29) in Caenorhabditis elegans produces an increase in fat stores. Rescuing expression of kin-29 in a subset of sensory neurons results in an abatement of peripheral fat stores, suggesting kin-29 may act in the sensory neurons of C. …
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