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Showing 1 to 2 of 2 for “"orthogonal translation system"”.
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Phosphoserine Incorporation into the Intrinsically Disordered N-terminal Domain of the p53 Tumor Suppressor Protein
… positions 15 and 37. The second is an orthogonal translation system consisting of two independent plasmids and genetically recoded Escherichia coli (E. coli). One plasmid is used for expression of p53(1-93) and the other for a phosphoserine (Sep) tRNA-synthetase system to permit …
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Structural requirements for enzymatic efficiency in cofactor-independent decarboxylation
Orotidine 5’-monophosphate decarboxylase (OMPDC) is the last enzyme in the de novo pyrimidine biosynthetic pathway. It catalyzes the decarboxylation of orotidine 5’-monophosphate (OMP) to uridine 5’-monophosphate (UMP), without the requirement of a cofactor. It provides catalytic rate enhancements …