Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"orthogonal protecting groups"”.
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
… units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological processes. However, procurement of pure, homogenous CS motifs for biological evaluation is a challenging task due to …
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Synthesis and Properties of Selectively Modifiable Cyclodextrin Analogues
… the selective functionalization of the hydroxyl groups on the macrocycle. A novel strategy for the synthesis of CD analogues is described which involves the use of [3+2] Huisgen cycloadditions between azide and alkyne functionalities to form the macrocycles from linear precursors. This strategy …
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The use of immobilised crown ethers as in-situ protecting groups for organic synthesis within flow reactors
… the selective reaction of another moiety. While protecting groups are used to remove the problem of the functional group incompatibility, they also raise other issues such as increasing the length of the synthetic pathway (by at least two steps – protection and deprotection), generally leading to …
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Development of novel polymeric architectures for applications in drug delivery and studies towards the synthesis of perfect polymers by iterative exponential growth "Plus" (IEG+)
… The IEG+ method utilized monomers equipped with orthogonal protecting groups: epoxides and alkynyl silanes. The epoxide functionality served both as a protecting group and as a masked synthon for alcohols, which allowed for side-chain functionalization of the IEG+ scaffold. Combing R- and …
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Synthetic Routes to Therapeutic Agents Via Masked Functionalities: From Orthogonal Peptide Crosslink to Photothermal Cancer Prodrug
… of this dissertation details the synthesis of an orthogonally protected ô-HAL building block that will be incorporated into a total synthesis of theonellamide C. Selective deprotection of each amine and acid of this orthogonally protected building block is also demonstrated. Various reaction …
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Partiell geschützte Blockcopolymere zur Darstellung von Polymerfilmen mit strukturierbarer und modifizierbarer Morphologie
… Makroinitiatoren mittels NMRP, 2) Synthese von orthogonal geschützten Precursor-Blockcopolymeren durch Reinitiierung der Makroinitiatoren in Gegenwart eines weiteren orthogonal geschützten Monomeren und 3) orthogonale und quantitative polymeranaloge Umsetzungen ausgehend von den orthogonal …