Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"orphan nuclear receptor"”.
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
<p>The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known …
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
The orphan nuclear hormone receptor, DAF-12, plays a central role in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress …
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Regulation of proliferation, apoptosis, and metastasis in prostate cancer cells by DAX-1 (NR0B1)- an androgen-induced orphan nuclear receptor
… gene 1) is an unusual member of the Nuclear Hormone Receptor superfamily that has the ability to interact with other Nuclear Receptors (NRs) and transcriptional co-repressors and co-activators. While DAX-1 plays an important role in adrenal and gonadal development, recent studies have …
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… (MIS). The Wilms' tumor suppressor (WT1) and the orphan nuclear receptor steroidogenic factor 1 (SF-1) bind cooperatively to the promoter of MIS and activate its transcription. In the ovary, on the other hand, the orphan nuclear receptor DAX-1 binds to SF-1. The binding inhibits WT1/SF-1 …
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
Farnesoid X receptor (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… we uncover a novel and critical role of the orphan nuclear receptor Nur77 in mediating an NFATc1 self-limiting regulatory loop to prevent excessive osteoclastogenesis. Nur77 deletion leads to low bone mass owing to augmented osteoclast differentiation and bone resorption. Mechanistically, …
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Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells
… the expression and function of Gcnf (germ cell nuclear factor), an orphan nuclear receptor known to regulate both Oct4 and Nanog in gastrulating embryos. I have found that Gcnf is expressed in a female germ-cell-specific manner at the time when Oct4 and Nanog are down-regulated there. Gcnf …
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
<p>DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing …
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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
… vertebrates and exerts its effects via the GnRH receptor (GnRHR) to result in the synthesis and release of the gonadotropin hormones in the pituitary gonadotrope cells. GnRHR expression is likely to be regulated in a tissue- and cell- specific manner. A variety of hormones, including GnRH itself, …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… are poorly understood. In recent years, two orphan nuclear receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate …
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A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
… further validation and examination of their subnuclear expression profile. One of the VMH markers, steroidogenic factor 1 (SF-1), is an orphan nuclear receptor with few known target genes. As this transcription factor is responsible for proper developmental formation of the VMH and also for …
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Identifying regulators of neural stem cell fate and tumourigenesis
… in post-mitotic progeny. In vertebrates, the orphan nuclear receptor TLX (also known as nuclear receptor subfamily 2, group E, member 1 or NR2E1) is expressed in NSCs both during development and in adults. TLX mutations are linked to microcephaly and hereditary cases of bipolar disorder, …
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Role of Src phosphorylation of FXR in bile acid regulation
… must be tightly regulated. The farnesoid X receptor (FXR) is the primary bile acid nuclear receptor and acts as the master regulator of bile acid homeostasis, preventing liver damage caused by bile acid accumulation. FXR does this by regulating the expression of many target genes in the gut …