Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 206 for “"orphan"”.
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The Protestant Orphan Society, Dublin, 1828-1928
… is primarily a study of the earliest Protestant Orphan Society, founded in Dublin in 1828. The geographical scope of the project is not solely confined to Dublin as reference is also made to Protestant orphan societies located in Monaghan, Cork, Meath, Westmeath, Carlow, Mayo, Limerick and …
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Transcriptional regulation of the inducible orphan nuclear receptornur77.
Transcriptional regulation of the inducible orphan nuclear receptornur77.
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Constitutive activity in orphan G protein coupled receptors
… agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular activation of different G proteins and subsequent second messenger synthesis. These small molecules …
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Orphan Drugs: Designations, Approvals, and Prices in the US
… dissertation assessed the characteristics of orphan drug designations and approvals and the factors associated with the time lag between orphan designation and approval in the US from 1983 to 2021. It also evaluated the treatment cost of orphan and non-orphan drugs and factors explaining the …
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'Orphan with a Gun' - A Graphic Novel Script and Pitch Package
<p><strong><em>Orphan with a Gun</em></strong> is an experimental graphic novel which introduces a new, gritty universe to the popularized ‘Child vs. Monster’ sub-genre—presented through a lens of dark satire and ultra-violence. <em>O.W.A.G.</em> further innovates on the norms of narrative visual …
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The Ambivalent Attitude Toward The Orphan in The Early Victorian Novel
In early Victorian fiction, orphans are seen as nurturing angels and as depraved beasts. This study analyzes why orphans are treated so ambivalently. It also explains how angelic waifs give serious-minded Victorians a way of contending with destructive change and moral breakdown and why depraved …
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Characterization of an Orphan Riboswitch: Identification of a Metal-Sensing Regulatory RNA
Riboswitches are RNA-based genetic control elements found in untranslated regions of the mRNA transcript that they regulate. These RNA motifs are highly structured and bind metabolites to elicit control of gene expression. Typically, the metabolite sensed by these RNAs is a component of the …
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The New Orleans Female Orphan Society: Labor, Education, and Americanization, 1817-1833
… poor, a group of women established the Female Orphan Society. From its creation, the Female Orphan Society worked in providing aid to indigent mothers and their children through providing religious, vocational, and educational training. In a short time, the FOS emerged as the only private, …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 …
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Annotating and characterizing orphan gene in Zea mays via diverse RNA-Seq data
… Most genes in the dark transcriptome are orphan genes. Orphan genes are the recently emerged young genes, which share no sequence similarity with proteins in any other species. In the last 20 years, thousands of orphan genes have been experimentally shown to play important roles in diverse …
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Voltaire: From Sacrificial to Judicial System in the Play The Orphan of China
… writing for the theater. One of his plays, The Orphan of China, was an adaptation of a Chinese play, The Orphan of the Mansion Tchao. Many critics contend that in this play Voltaire is: 1. Propagating the spirit of the Enlightenment to the Europeans via his representation of the Chinese; 2. …
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Future crop suitability assessment and the integration of Orphan crops into Kenya's food systems
… a significant suitability increase (50%) of the orphan crop- broad bean- during the dry season. The spatial distribution of suitability is widespread within many arid and semi-arid counties. This presents an opportunity to integrate legumes such as broad bean into the cropping system within a …
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Defining and Analyzing Negative Policy Transfer: National Orphan Drug Regulatory Policy in Canada and Australia
… in political science: the transfer of national orphan drug regulatory policies in Canada and Australia. These cases present a puzzle for researchers, as Australia was an early adopter of a national regulatory policy in line with other jurisdictions internationally, while Canadian policymakers …
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A Wonder Whose Origin is not Known: The Importance of the Orphan Hero in Otherworldly Film
… this thesis is to explore the importance of the orphan hero in film and his resonance with the American people. It explores the orphan and the American identities, the archetypes found in myths, and the hero in American culture. The three heroes (Batman, Anakin Skywalker, and Harry Potter) …
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Addressing the Needs of Patients with Rare Diseases in Canada: An Evaluation of Orphan Drug Incentives
… is currently uncertain whether or not a Canadian orphan drug policy will be given further consideration any time in the near future, this thesis seeks to consider the potential impact that three different orphan drug incentives could be expected to have in Canada. Specifically, market exclusivity, …
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A Safe House for Orphan Parts an Architectural Proposal for a US Center for Illicit Antiquities
… leaving a vast aging building stock of military orphans. Traditional building typologies including munitions storage, forts, and bunkers have been superseded but are expensive or difficult to demolish. In addition, these spaces are crafted around defensive, introverted narratives. A Safe House …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… are poorly understood. In recent years, two orphan nuclear receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate …
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The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways
… extracellular domains in the AMPA, kainate, and orphan delta receptor, all which create trans-synaptic complexes in the brain. My studies reveal that coupling of the extracellular domains increases the intrinsic activity of the AMPA and kainate receptor and induces the delta receptor to have …
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