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Showing 1 to 15 of 15 for “"organozinc"”.
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Catalytic asymmetric addition of organozinc reagents to aldehydes and ketones
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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The generation and reactivity of functionalised organozinc carbenoids for cyclopropane synthesis
… the generation and reactivity of functionalised organozinc carbenoids for cyclopropane synthesis with alkenes. In the introductory chapter, a brief overview of the different methods for preparation of heteroatom-functionalised cyclopropanes is presented, including [2+1] cycloaddition reactions …
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1. C-C Bond Formation via Soft Enolization and Umpolung-like Chemistry 2. Electrophilic Fluorination of Organozinc Reagents
… formation via electrophilic fluorination of organozinc compounds. We hope this will have wide applicational utility as C-F bonds are important within agrochemistry and pharmaceutical chemistry.
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Enantioselective synthesis and reactivity of bicyclobutanes: strained molecular platforms for 4-, 5-, and 6-membered ring synthesis and rhodium(II)-catalyzed reactions of diazoesters with organozinc reagents
… expansion reactions, and the rhodium-catalyzed organozincation of diazoesters. The rich chemistry of diazocompounds rapidly builds complexity across many modes of reactivity. The propensity of Rh(II)-carbenes to undergo β-hydride migration has been a long standing limitation to this chemistry. …
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Progress in nucleophilic catalysis and development of nickel-catalyzed cross-couplings of propargylic halides
… secondary propargylic halides with a variety of organozinc nucleophiles. Section 2.2 describes progress toward an asymmetric alkylation reaction. In Section 2.3, the development of the first alkyl-alkyl secondary-secondary cross-coupling is described; Section 2.4 describes the application of this …
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New Strategies for the Synthesis of Amines, Ethers and Small Strained Rings
… of aryl Grignard, organolithium, or organozinc reagents to the corresponding organocopper species and subsequent reaction with a di-tert-butyl NH-oxaziridine. The use of less basic organocopper reagents expands the substrate scope to incorporate electron-deficient and heterocyclic …
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Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
… the coupling of a variety of alkyl- and aryl- organozinc reagents providing the corresponding products in good to quantitative yields. Moreover, the developed protocol is generally applicable and tolerant of a variety of functional groups including esters, and nitriles. Part II: An improved and …
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New reactivity and selectivity in transition metal-catalyzed C-C and C-N bond forming processes
… Negishi Coupling of 3,3-Disubstituted Organozinc Reagents with Aryl and Vinyl Electrophiles A palladium-catalyzed general and completely linear-selective Negishi coupling of 3,3- disubstituted allyl organozinc reagents with (hetero)aryl and vinyl electrophiles has been developed. This …
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Nickel precatalysts as enabling tools for catalytic coupling reactions
… of aliphatic N-tosylaziridines with aliphatic organozinc reagents is described. The reaction protocol displays complete regioselectivity for reaction at the less hindered C-N bond, and the products are furnished in good to excellent yield for a broad selection of substrates. An air-stable …
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New applications of heteroarylzinc nucleophiles
… 2. Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6- Trichlorophenyl Chlorosulfate. A method for the preparation of aryl and heteroaryl sulfonamides using 2,4,6-trichlorophenyl chlorosulfate (TCPC) is described. The reaction of 2-pyridylzinc reagents with TCPC resulted …
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A new synthesis of enantiomerically pure bicyclic ketones. Total synthesis of the diterpenoids (-)-Kolavenol and (-)-Agelasine B
… 214. A novel palladium-catalyzed coupling of an organozinc reagent (prepared from 213) with the vinyl iodide 265 produced the ether 282. (-)-Kolavenol (65) was obtained by removal of the silyl protecting group. (-)-Agelasine B (31) was obtained in three steps from the ether 282. Thus, 282 was …
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Nitric oxide reactions of bio-Inspired zinc and cobalt complexes
… chemistry is discussed. Chapter 3. Reactions of Organozinc Thiolates with Nitrosonium Ion: C-Nitroso Formation by Intramolecular Transnitrosation The organometallic species [ZnPAThEt] and [ZnPAThMes] are prepared, and their reactions with NOBF4 are characterized. The formation of C-nitrosoethane …