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Showing 1 to 20 of 24 for “"organic cation"”.
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
… how it is subsequently secreted into the urine. Organic cation transporter 2 (OCT2) and ABCC2 are highly expressed in the kidney on the basolateral and apical membrane, respectively. We determined the contribution of OCT2 and ABCC2 to cisplatin transport and toxicity. We also evaluated the …
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IN SILICO CHARACTERIZATION OF THE RECOGNITION MECHANISM OF RIBOFLAVIN TRANSPORTERS RFVT1, RFVT2, AND RFVT3, AND ORGANIC CATION TRANSPORTERS OCTN1 AND OCTN2
… e sono specifici per una vasta gamma di cationi organici endogeni ed esogeni. Anche questi trasportatori sono stati osservati essere overespressi nelle cellule tumorali e sono stati identificati come trasportatori di farmaci; quindi, una caratterizzazione approfondita del loro sito di …
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Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Protein in the Placenta: Expression, Localization and Function
… František Štaud, Ph.D Název disertační práce Organic cation transporter 3 (OCT3) a multidrug and toxin extrusion protein 1 (MATE1) v placentě: exprese, lokalizace a funkce. Cílem této studie bylo popsat expresi, lokalizaci a funkci dvou transportérů, organic cation transporter 3 (OCT3) a …
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Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
… labile leaving groups and two am(m)ine ligands. Cationic, platinum(IV), and multinuclear complexes are considered. Advances in tumor targeting using platinum complexes are also discussed. Chapter 2. Structure-Activity Relationship for the Uptake of Platinum(ll) Compounds by Human Organic Cation …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… systems expressed at the BBB. The identification and functional characterization of such transport systems is essential to provide a basis for strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells (RBE4 cells) have been used in this study as an in …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… renal drug transporters and absolute quantification of membrane transporter proteins by LC-MS/MS, we found that atenolol is an excellent substrate for the renal organic cation transporter 2 (hOCT2), multidrug and toxin extrusion proteins 1 and 2-K (hMATE1 and 2-K). It can inhibit but not be …
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Steric Effects of Alkyl Ammonium Salts on the Combustion of Exchanged Smectite Clays
… was explored as a new method for determining the cation exchange capacity (CEC) of clays. Smectite clays were modified with several alkyl ammonium salts varying in number of carbons and the spatial orientation of the carbons about the central nitrogen atom. The clays used, standards purchased from …
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Bioaktyviųjų joninių skysčių aukštosios skyros BMR tyrimas /
… ionic liquids. The ionic liquids are composed of organic cation molecules and organic or inorganic molecule anions. IL have low melting temperature; low vapour pressure and their chemical structure can be altered. b-RTILs are different from the regular IL since b-RTILs are compatible with the …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… and ATP7B for influx and efflux respectively. Organic cation transporters (OCT) did not play an important role in BBR3464 cellular uptake, however, desipramine, an OCT inhibitor had synergistic effects on platinun drugs-induced cytotoxicity. This effect is of high clinical relevance since …
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Electrical properties of some low-dimensional compounds
… the potassium replaced with a large, asymmetric organic cation. Diffuse x-ray scattering shows evidence of a Peierls distortion in GCP at room temperature. Data from heat capacity, infrared, and magnetic susceptibility experiments provide confirmation that the effective Peierls transition …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
… use in treating gastrointestinal cancers. Organic cation transporters (OCTs) may contribute to the tissue accumulation and unwanted toxicities of oxaliplatin. The overall aim of this thesis was to develop new bioanalytical methodologies for studies of oxaliplatin chemotherapy when given …
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Characterization of a human renal organic anion transporter
The renal excretion of organic anions, including a variety of endogenous substances, xenobiotics and their metabolites, involves an organic anion transport system with multiple specificity. The well characterized basolateral uptake step of this process involves the organic anion transporter 1 …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… Monoamine Transporter 2 (VMAT2) for applications in high throughput screening of VMAT activity and inhibition, as well as for imaging aminergic synaptic transmission in brain tissue. Chapter 3 describes the discovery of fluorescent probes FFN201 and AGH093 as dual substrates for the …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… ions, inhibitors or competitive substrates of organic cation transporters (OCT), organic anion transporters (OAT/OATP), and multi-drug-resistant efflux transporters eliminated effects of major groups of these transporters on AFB1 accumulation. The data indicated one or more unidentified proton …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… These results support the concept of an organic anion/dicarboxylate exchanger involved in cortisol release and PAH uptake into adrenocortical cells. Additionally, a sodium-dependent succinate uptake was also demonstrated in bovine adrenocortical cells. The uptake was inhibited by lithium, …
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Defining CP-CML patient subsets associated with poor imatinib uptake and response.
… to sub-optimal response or imatinib failure. The organic cation transport-1 (OCT-1) protein is the major active protein involved in imatinib transport. Measuring the function of OCT-1 in leukaemic mononuclear cells prior to imatinib therapy, expressed as OCT-1 activity (OA), has been demonstrated …
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Ionic liquids for main group catalysis
… two key challenges: the use of an expensive organic cation which plays no role in the catalytic process and placing the Lewis acidic function on the chloroaluminate anion, which does not allow for further modification of catalytic activity. <br/><br/>The first of the two shortcomings has been …
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Engineering the Synthesis and Properties of Two-Dimensional Colloidal Perovskite Nanoplatelets
… for a wide range of optoelectronic applications including photovoltaics, displays, photodetectors, and thermoelectrics. Their colloidal stability enables facile device fabrication by providing solution processability, and tunability of the bandgap with particle size opens up the …
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Redox and complexation chemistry in chloride ionic liquids and molten salts
… nuclear technologies and other green energy applications. In particular, molten salts based on the chloride anion have garnered prevalence among innovative molten salt reactors and pyrochemical reprocessing where there is a trove of novel lanthanide and actinide chemistry that must be well …
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Synthesis, structure and mechanism of polyoxometalate self-assembly: towards designed nanoscale architectures
… of higher mass fragments, each with increasing organic cation contribution concomitant with their increasing metal nuclearity, has supported the previously proposed hypothesis that the organic cations have a structure-directing role in promoting the mode of POM structure growth in solution. The …
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