Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"organic anion transporters"”.
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… is maintained despite a down-regulation of the organic anion transporter Oatp1. Thus, expression of the two other rat Oatps (Oatp2 and Oatp4) was determined in estrogen-induced cholestasis. In Addition, known transactivators of Oatp2 and Ntcp were studied to further characterize transcriptional …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… this effect we first determined whether specific transporters affect the accumulation of AFB1 in HepG2 cells. Effects on AFB1 accumulation by pH, selected ions, inhibitors or competitive substrates of organic cation transporters (OCT), organic anion transporters (OAT/OATP), and …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… These results support the concept of an organic anion/dicarboxylate exchanger involved in cortisol release and PAH uptake into adrenocortical cells. Additionally, a sodium-dependent succinate uptake was also demonstrated in bovine adrenocortical cells. The uptake was inhibited by lithium, …
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Structures and Mechanisms of Lysosomal Transporters
Lysosomal membrane transporters are indispensable for maintaining lysosomal homeostasis and proper function. Indeed, mutations in these key proteins can lead to debilitating disorders known as lysosomal storage diseases. Cystinosin and Sialin are two such transporters. Both proteins utilize the low …