Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"organ-on-chip"”.
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Development of a Smoke Exposure System for Organ-on-Chip Applications
… an increasingly popular alternative to traditional smoking in recent years. However, its long-term impacts on health are not yet fully understood. There is therefore a need for further research and testing platforms that can be used to accurately evaluate the health impacts of vaping. This …
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Modeling Pathophysiology of Human Fallopian Tube Using Microfluidic Organ-on-Chip Technology
… is crucial for the development of future detection and intervention strategies. This thesis leverages primary human fallopian tube tissue and organ-on-chip technology to understand the impact of tumor-derived extracellular vesicles on fallopian tube and model the polycystic ovarian syndrome. Our …
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Generation of human inner ear organoids from pluripotent stem cells and an organ-on-chip platform
… mimic both the complex structure and the function of the inner ear outside of the body. Since the human inner ear is difficult to biopsy, a major challenge is to accurately recapitulate the embryonic development of the inner ear from hiPSCs. However, our limited understanding of the …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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Development of a hydrogel-based microfluidic model of the lymph node
… meet to mount antigen specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune response. The TDLN undergoes dramatic reprogramming in response to tumour drainage that is still partly unclear. In vivo models do not easily permit …
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Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
The introduction of in vitro systems that can mimic organ physiology and allow studying the progression of diseases such as cancer is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
Severe influenza affects 3-5 million people worldwide each year, resulting in >300,000 deaths. Standard-of-care antiviral therapeutics have limited effectiveness in these patients where infection severity is driven by an aberrant immune response. In severe influenza, the hyperactive immune system …
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Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition
… cavity and perform protective functions during pregnancy. Rupture of membranes before term is deemed ‘catastrophic’ and contributes to infection, preterm birth, and neonatal death. During gestation, membranes repair and remodel through a balanced collagenolytic process of the matrix. …
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Precision hot-melt freeform 3D printing for monolithic multilayer microfluidics
Miniaturization and integration of assays, chemical synthesis, and cell culture models onto microfluidic chips is an intensive area of research. Despite the diversity of these applications, the vast majority of microfluidic devices are fabricated from polydimethylsiloxane (PDMS) using the same …
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Design and evaluation of an instrumented microfluidic organotypic device and sensor module for organ-on-a-chip applications
Organ and tissue-on-a-chip technologies are powerful tools for drug discovery and disease modeling, yet many of these systems rely heavily on in vitro cell culture to create reductionist models of tissues and organs. Therefore, Organ-on-chip devices recapitulate some tissue functions and are useful …
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Innovative microphysiological systems for long-term real-time imaging in biomedicine
… could behave like in vivo. So far, identification and selection of pharmaceutical compounds have occurred through standardized protocols based on traditional in vitro cultures, animal models and, lastly, human trials. This well-established operating structure consented to advance people’s health …
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… plays an important role in drug absorption and drug elimination. Therefore, it is crucial to understand the mechanism and kinetics of drug metabolism by various drug-metabolizing enzymes (DMEs). Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of more than 60% of the top …