Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"organ transplantation"”.
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Targeted Priority Mechanisms in Organ Transplantation
The persistent shortage of transplantable organs, compounded by high rates of organ underutilization, necessitates innovative allocation mechanisms. This dissertation develops and analyzes targeted priority mechanisms, voluntary incentive-based programs designed to enhance access for disadvantaged …
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Quality Management: A Global Case Study in Organ Transplantation
… US and European countries face an epidemic of organ failure from a multitude of reasons: cancer, genetic predisposition, exposure to harmful chemicals in home or surrounding areas or through drinking, drugs and smoking. Another problem faced, is the ratio of organ donors to organ recipients. …
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An Interpretable Multimodal Framework for Regional Organ Transplantation Outcomes
… different demographics and amounts of data on organ acceptances (Region 1: 43,126 offers with 2.19% acceptance rate, Region 2: 394,640 offers with 1.57% acceptance rate, Region 3: 169,342 with 2.23% acceptance rate in years 2016-2019). Among the baseline XGBoost models, Region 3 achieved the …
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Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
Organ transplantation is the only treatment for patients with severe and irreversible organ damage. Although the efficacy of transplantation has progressed immensely in recent years, one of the most damaging factors occurring during this surgical procedure, ischaemia reperfusion injury (IRI), is …
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The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
… injury and mitochondrial dysfunction in organ transplantation Ischaemia and subsequent reperfusion is inherent to solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for transplantation in the UK has led to the …
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The failure of altruism: Alternatives to improve the donor rate in organ transplantation
Ethical and moral issues facing potential organ donors, their families or agents, and the medical community are created and driven by the rapidly expanding demand for the life-giving resource (ever more successfully utilized)--a factor coupled with the persistently scarce and relatively constant …
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Brain Death, Organ Transplantation and the Ethics of Relationships in Japan: 1968-2000
<p>The center of the brain-death and organ transplantation debate in Japan has always been whether whole brain-death should be regarded as the death of a person. However, the debate has not yet been settled in Japanese society. There are four main reasons why it is said that whole brain-death …
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Nurses' perceptions of clinical competency and individualized care in relation to solid organ transplantation
… and individualized care (IC) levels for solid organ transplant (SOT) recipients, living donors, and their families while also exploring the relationships among nurse characteristics, TNC, and IC. Three hundred ninety-one participants, comprising U.S. nurses caring for SOT recipients, living …
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Comparative analysis and predictors of biopsychosocial functioning in various health conditions: multiple sclerosis and organ transplantation
… since diagnosis of multiple sclerosis/time since transplantation surgery until assessment (first work), and controlling for age (in the second study) as covariates. The comparative framework underlying both works is very suitable from a clinical point of view, as both populations share …
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Characterisation of Alloantibody-Human Leukocyte Antigen Interactions to Improve Immunological Risk Assessment in Solid Organ Transplantation
… rejection remains a major challenge in solid organ transplantation, where the development of immunoassays for characterisation a recipient’s donor HLA-specific antibodies has revolutionised the field of solid organ transplantation. These immunoassays are essential for patient evaluation, …
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The gift of life: an existential phenomenological exploration of receiving a lifesaving organ transplant and how this affects life subsequently
At present, there is little research conducted on organ transplantation from the perspective of the organ recipient. This study aimed to explore the experience of undergoing lifesaving organ transplantation and how this may affect life subsequently. For the purpose of this research, lifesaving …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… of ischaemia. It is an inevitable consequence of organ transplantation, where its severity contributes to reduced levels of graft function and survival. There are no clinically approved pharmacological therapies available to ameliorate the effects of IR injury in organ transplantation or other …
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Investigations of the Genetic aspects of the mixed Lymphocyte culture reaction in Southern Africa
… complete answer to donorrecipient selection in organ transplantation. This study was therefore initiated in June 1971 in an attempt to clarify the problem. It is inherent in a project of this nature that much time is spent in collecting samples from donors in diverse areas. Most experiments had …
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Probing the role of cell-cell interactions in hepatic ensembles
While organ transplantation is one of the greatest advances of modern medicine and provides immense therapeutic benefit to patients suffering from severe and fatal liver disease, donor tissue is scarce. Alternatives such as engineered cell-based therapies aim to restore tissue-specific functions of …
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
… is crucial to provide an alternative to whole organ transplantation or even for temporary support throughout medical intervention. The development of functional solid organ systems like the liver is an arduous task and faces many challenges. This thesis sought to address two of these …
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Organ allocation and patient responsibility: Re-examining the concept of responsibility in light of the thought of Emmanuel Levinas.
… The focus chosen was the need for replacement organs for those whose illnesses appear to be related to addiction to alcohol or tobacco. The initial section thus examines the more factual aspects of both addiction and organ transplantation. The history of organ transplantation is explored, …
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3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications
Organ transplantation would be the first option for those whose tissues/organs have been extremely injured. However, the growing gap between the number of organ donors and receivers has resulted in the long waiting list for organ transplantation. Regenerative medicine has emerged as a promising …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… in 1990s, the Edmonton Protocol for human islet transplantation has helped more than 500 patients with type 1 diabetes worldwide and met great success from bench to bedside. The Edmonton Protocol involves isolating islets from a cadaveric donor pancreas by enzymatic digestion and infusing into …
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