Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 54 for “"organ specific"”.
-
Analysis of organ-specific gene expression in soybean
Organ specificity is an important criterion to be considered for the expression of foreign genes in plants. For crop improvement by genetic engineering it is critical to introduce genes in specific organs that can be expressed at an appropriate developmental stage. This study involved the analysis …
-
Phenotypic and functional analysis of organ specific endothelial cells
… common stages during recruitment in different organs, there is also specialisation in underlying molecular mechanisms. The main aim was to further elucidate these organ specific phenotypic differences and relate them to the functional ability of EC to recruit subsets and total leukocytes from …
-
Organ-specific heterogeneity in the endothelial cell hypoxia response
… Previous work had shown that lung endothelial-specific knockouts of HIF-1α and HIF-2α respectively inhibit and promote metastatic success. Thus, hypoxic stimuli of varying lengths were used to preferentially stabilise either HIF isoform prior to tumour cell injection. Acute hypoxia resulted in …
-
Organ Specific Vascular Response to Fibrosis Affects Breast Cancer Metastatic Organotropism
… characterized that primary tumor metastasis has specific organotropism, for example breast cancer commonly spreads to the lungs, brain, bone, liver and lymph nodes. However, whether non-organtropic fibrosis can redirect metastasis to the damaged organ has not been investigated.</p> <p>To …
-
Organ-specific regulation and molecular evolution of the maize pericarp color1 gene
… the flavonoid biosynthetic pathway in floral organs, most notably kernel pericarp and cob. Alleles of the p1 gene condition distinct tissue-specific pigmentation patterns. To elucidate the molecular basis of these allele-specific expression patterns, we characterized two novel P1-rw alleles, …
-
Unraveling sorghum stem biology through organ-specific and cell-type-specific transcriptomic analyses across development
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
-
In vitro study of cancer cell extravasation in microfluidic platform
… steps of extravasation. First, a general non-organ-specific cancer cell extravasation model is developed in which the endothelial cells that cover the walls of the microfluidic channel represent the vessel endothelium, and the entire extravasation process including tumor cell adhesion to the …
-
ΧΗΜΙΚΗ ΑΝΟΣΙΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΕΝΕΡΓΟ ΗΠΑΤΙΤΙΔΑ ΣΕ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΤΟΥ HBSAG
… MEASLES AND CYTOMEGALOVIRUS (CMV) AND NON-ORGAN SPECIFIC AUTOANTIBODIES - ANTINUCLEAR (ANA), SMOOTH MUSCLE ANTIBODIES(SMA), AND ANTIMITOCHONDRIAL ANTIBODIES (AMA) - WERE STUDIED. THE IMMUNOGLOBULINS WERE DETERMINED BY SINGLE RADIAL IMMUNODIFFUSION. THE VIRAL ANTIBODIES WEREDETECTED BY THE …
-
Risk and Risk Factors For Colorectal Subsequent Malignancies In Survivors of Childhood Cancer: A Report From The Childhood Cancer Survivor Study
… diagnosed with a colorectal SMN. These detailed organ-specific RT metrics were included in dose-response models for predicting colorectal SMN risk in the CCSS. We provided an update of risks and associated risk factors for colorectal SMN risk in the CCSS with demographic, behavioral and treatment …
-
Understanding grapevine responses to abscisic acid
… (Vitis vinifera) responding to ABA, different organs of grape (berries, shoot tips, leaves, roots and cell cultures) were treated with 10 μM (S)-(+)-ABA for 2 h. NimbleGen whole genome microarrays for genes of Vitis vinifera were used to determine the effects of ABA on organ-specific mRNA …
-
Endocrine Effects of Cancer Chemotherapy
… effects of cancer chemotherapy on endocrine organs, emphasizing both therapeutic advantages and adverse effects. It categorizes chemotherapeutic agents based on their mechanisms of action and their impact on endocrine function, highlighting both intended hormonal modulation and unintended …
-
Isolation of the aldose reductase gene (XvAld1) from the resurrection plant Xerophyta viscosa, and characterisation of the gene product and transgenic plants expressing the gene
… leading to stress tolerance. The genomic organisation of XvAld1 was characterised using Southern blot analysis and DNA sequencing. The results revealed more than one copy of the gene with a complex banding pattern that was partially resolved by sequencing. The sequencing of PCRamplified …
-
Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
… NPs are associated with expansion of antigen-specific T-regulatory-type-1 (Tr1) cells and immuno-suppression of autoantigen-loaded antigen presenting cells (APCs) in an IL-10 and TGF-beta-dependent manner. We have established that suppression is disease- and organ-specific and effective in …
-
Engineered, perfusable, human microvascular networks on a microfluidic chip
… will aid in the design and engineering of organ specific constructs for tissue engineering and regenerative medicine applications. Finally, we explored the potential use of stem cells for engineering microvascular networks in our system. We found that human mesenchymal stem cells can act as …
-
The spatial and temporal regulation of the transcriptome during plant development
The dicotyledon seedling undergoes organ-specific photomorphogenic development when exposed to light. The cotyledons open and expand, the apical hook opens and the hypocotyl ceases to elongate. Using the large and easily dissected seedlings of soybean (Glycine max cv. Williams 82), we show that …
-
Meta-analysis of liver transcriptomic data identifies accurate disease classifiers and disease perturbed networks
… In this study, we took a comprehensive and organ-specific approach, where we studied all liver pathophysiological states in a single unifying context, and found a specific transcriptomic signature for each phenotype with respect to all the other phenotypes, instead of just one. The resulting …
-
Meeting the oxygen requirements of an isolated perfused rat liver
Liver perfusion systems can be used as organ culture platforms for metabolic, genetic and systems engineering, tissue regeneration, pharmacokinetics, organ storage and marginal donor reconditioning for transplantation. The primary requirement of such a system is that it maintain ex vivo organ …
-
Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid homeostasis, adaptive immune …
-
Design and fabrication of physiologic tissue scaffolds using projection-micro-stereolithography
… this means that the mechanics and function of an organ are defined by structural organization on multiple levels. Macroscopically, a branching blood supply creates a patent network for nutrient delivery and gas exchange. Microscopically, these vessels spread into capillary beds shaped in an …
-
Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
… Whole-cell autophagy markers were stable in both organs. Subcellular analyses, limited by crude fractions from snap-frozen tissue, revealed innate organ differences preserved under CRS: liver displaying higher heavy-membrane recovery of LC3B-II and SNAP29, consistent with its greater constitutive …
Page 1 of 3