Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"organ size control"”.
-
The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
-
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… Hippo pathway that plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a novel oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation …
-
Genetic Analysis of The Hippo Pathway In Mouse Liver
<p>Cancer therapy and tumor treatment remain unsolved puzzles. Genetic screening for tumor suppressor genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the …