Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"organ size"”.
-
The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
-
The genetic and developmental bases of male genital organ size evolution
… lobes, for example, are very different in both size and shape between these species. Both of these organs have important roles in copulation. Therefore, this process of rapid morphological evolution is thought to be driven by sexual selection and may reinforce the separation of species. However, …
-
Poly(A) Polymerase 1 (PAPS1) influences organ size and pathogen response in Arabidopsis thaliana
… mutant in PAPS1 leads to increase in floral organ size, whereas leaf size is reduced. A strong loss-of-function mutation causes a male gametophytic defect, whereas a weak allele leads to reduced leaf growth. By contrast, plants lacking both PAPS2 and PAPS4 function are viable with wild-type …
-
Examination of Direct and Indirect Effects of Legacy Industrial Pollution On Organ Growth in Wild Yellow Perch (Perca flavescens)
… investigated the effects of chronic pollution on organ growth in fish. Specifically, I examined which organs are most sensitive to pollution and whether these changes were prompted by the indirect effects of impoverished food webs resulting from chronic pollution or the direct toxic effects of …
-
Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… cascade is critical for both regulation of organ size in development and tumor suppression. Several mechanisms, such as cell-cell contact in vitro and organ size in vivo, have been implicated in the activation of the Hippo pathway, leading to inactivation of the YAP/TAZ transcriptional …
-
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… Hippo pathway that plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a novel oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation …
-
Characterization of Gf a Drosophila trimeric G protein alpha subunit
… of patterning and growth achieve the correct organ size and shape is a principal question in biology. Efficient orchestrating mechanisms are required to achieve this and cells have developed sophisticated systems for reception and interpretation of the multitude of extracellular stimuli to …
-
Bromide residues in tissues from rats maintained on diets fumigated with methyl bromide
… in rat diets on tissue bromide accumulations, organ size, growth rate and physical activity were studied. In Experiment 1, the treatment groups were fed diets containing 290, 600 and 1177 ppm bromide, respectively. The control group received 36 ppm from untreated feed. There were 12 rats on …
-
Multiple axes of inter-organ signaling regulate organ scaling
The mechanisms governing static allometry of organ size has long been enigmatic. A central hypothesis predicts that during animal growth, body size is perceived by organs via inter-organ signals, which directs organ growth to match body size. Ligands of the Transforming Growth Factor β (TGFβ) …
-
Can plant survive without steroids: Modulation of plant architecture and sex determination through brassinosteroid biosynthesis and signaling
… and plant architecture traits, including organ size, sex determination, and leaf angle. However, genetic mechanisms by which BRs regulate plant architecture traits in maize remain poorly understood. We have generated and characterized several brassinosteroid biosynthesis and signaling …
-
Genetic modeling of the Hippo pathway in hematopoietic stem cells
… discovered signaling pathway, which regulates organ size in Drosophila. Hippo signaling has further been implicated in regulation of mammalian stem cells. In Article I we developed a new way of modeling genetic changes by combining genetic engineering of murine ES cells with blastocyst …
-
Investigating the role of DA1 in growth control.
… A detailed understanding of the growth of plant organs in general is paramount if such advances are to be made. Utilising previously characterised regulators of plant organ growth, this thesis explores the molecular mechanisms involved in the setting of final organ size. This thesis capitalises …
-
What are southern Cape renosterveld geophytes storing in their underground organs?
… Africa, because they possess underground storage organs adapted to unpredictable climates. This study analysed the storage reserves of geophyte species from the southern Cape renosterveld, to determine if reserve concentrations varied with storage organ size and if different storage organ types …
-
Abundance and Localization of (Yes-associated protein) YAP in Prepubertal Bovine Mammary Tissue
… evolutionarily conserved pathway that regulates organ size in many animal species; it might contribute to mammary growth in dairy heifers. This pathway is mediated by yes-associated protein (YAP) and through downstream gene transcription activation, results in cell proliferation. Because YAP has …
-
Cell Polarity Regulates Organ Growth Through The Hippo Pathway
… with growth control pathways in developing organs to achieve appropriate organ size remain obscure.</p> <p>To investigate the function of apical determinants in growth regulation, I investigated the mechanism by which the apical determinant Crumbs affects growth in <em>Drosophila</em> …
-
Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… is a major regulator of tissue growth and organ size. Hippo and TGFβ pathways are intimately interconnected. Hippo pathway mediators Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically localized Taz/Yap reduces or prevents Smad nuclear …
-
Studies of the Hippo Signaling Pathway
How multicellular organisms control their growth to reach proper organ size during development is a fascinating question. Recent studies, initially from Drosophila, have identified the Hpo tumor suppressor pathway as a crucial mechanism that controls tissue growth by inhibiting cell growth, …
-
Intergenerational effects of early life programming: the role of glucocorticoids and maternal obesity
… can ‘program’ alterations in gene expression, organ size, and cell number. This has been termed “the early life origins of disease’. There is also evidence that these programmed effects are not limited to the first generation but can also be passed to subsequent generations. With changes in …
-
The direct injection of CRISPR/Cas9 system into porcine zygotes for genetically modified pig production
… in aspects such as physiology, immunology, and organ size. Because of these similarities, genetically modified pigs have been generated for xenotransplantation. Also, when using the pig as a model for human diseases (e.g. cystic fibrosis transmembrane conductance regulator), the pig exhibited …
-
Understanding and Mimicking the Fly's Directional Hearing: Modeling, Sensor Development, and Experimental Studies
… microphones. In nature, animal hearing organs are also governed by the size constraint; the smaller the organ size, the smaller the available directional cues for directional hearing. However, with an auditory organ separation of only 520 µm, the fly Ormia ochracea is found to exhibit …
Page 1 of 2