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Showing 1 to 16 of 16 for “"organ preservation"”.
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Transplant organ preservation cooler
A method for preserving transplant organs for extended periods of time has been developed in the transplant organ preservation cooler. The preservation cooler enhances organ viability by maintaining a temperature controlled organ bath and pumping perfusate through the transplant organ. The emphasis …
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Philosophies of Pipe Organ Preservation: Case Studies of Three Churches In Columbia, South Carolina
<p>This study examines the preservation philosophies employed by three historic churches in Columbia, South Carolina in relation to their pipe organs. Existing scholarship on historic pipe organs focuses on their technical conservation as well as their significance to the history of music and …
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Effects of two different behavioral swallowing exercise protocols performed during radiation therapy on swallowing physiology, function, quality-of-life and weight outcomes following organ-preservation treatments for head and neck cancers
Objective: The purpose of this study was to investigate the effects of two different prophylactic behavioral swallowing exercise regimens performed by head and neck cancer/s (HNC) patients during radiation therapy with/without chemotherapy (RT/C) on swallowing physiology, function, quality-of-life …
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The Application of BioHeat Perfusion Sensors to Analyze Preservation Temperature and Quantify Pressure Ischemia of Explanted Organs
The development of an organ preservation system (primarily kidneys and livers, but could be adapted to fit hearts, lungs, and even limbs in the future) that can provide surgeons and doctors with real-time quantitative feedback on the health of the organ would be a significant improvement on current …
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Cardiac Organogenesis: 3D Bioscaffolds, Bioenergetics and Regeneration
Each year the Organ Procurement and Transplantation Network (OPTN) reports an increase in patients requiring an organ transplant without an increase in available donor organs, leading to a transplant gap that continues to widen. Over 70% of donor hearts are deemed unsuitable for transplantation …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
Heart transplantation relies on effective donor organ preservation to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, …
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In-Silico design and verification of an extracorporeal normothermic cardiac perfusion system for use during heart transplantation procedures
Heart transplantation relies on effective donor organ preservation to ensure successful graft viability. Since the first human heart transplant in 1967 by Christiaan Barnard, organ preservation techniques have evolved from static cold storage with cardioplegic arrest to continuous blood perfusion, …
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Conformal Additive Manufacturing for Organ Interface
… to monitor the molecular trajectories of whole organs throughout the clinically relevant ischemic interval is a critical problem underlying the organ shortage crisis. Here, we report a novel technique for fabricating manufacturing conformal microfluidic devices for organ interface. 3D conformal …
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In Vitro Effects of Actively Delivered Coencapsulated Curcumin and Cisplatin Nanoliposomes on Squamous Oral Carcinoma
… harsh surgery. This may also help in better organ preservation and functioning, which in turn would improve the overall quality of life in patients with these tumors.
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Hypothermic Machine Perfusion of Composite Tissues
Organ perfusion systems have successfully been applied to solid organ preservation and subsequent transplantation. However, their use in limb preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated. This thesis explores the potential for …
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Probabilistic Analysis of the Material and Shape Properties for Human Liver
… impact speeds. In addition, the influence of organ preservation on the biomechanical responses of animal livers was investigated using indentation and tensile tests. Results showed that the first five modes of the human liver shape models accounted for more than 70% of the overall anatomical …
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Development of Optimal Electromagnetic Resonance Rewarming Technology for Cryopreservation
The development of successful cryopreservation technology has been restricted to small biological materials due to the limited effective rewarming techniques. Either for conventional cryopreservation techniques which remain a certain fraction of ice crystals or vitrification which aims to exclude …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… due to the inadequate supply of available organs. A major factor limiting the donor pool relates to the poor ischemic tolerance of hearts removed and stored prior to implantation. Currently used heart preservation techniques involve storage of the organ near 0ºC to minimize donor organ …
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ASSESSING PREDICTIVE MODELING APPROACHES FOR OPTIMIZING THERAPY IN ADVANCED LARYNGEAL AND HYPOPHARYNGEAL CANCERS
… and partial laryngectomy, is highly invasive, organ-preservation strategies are frequently preferable as they help maintain organ functionality. Induction chemotherapy (ICT) is one such preservation approach; however, it is not suitable for all patients and may contribute to drug resistance in …
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Optical spectroscopy for biological and biomedical applications: potentially impacting future of healthcare with research, clinical translation and education
… features associated with carcinogenesis and organ viability for transplantation. Previous studies cover the selection and optimization optical techniques for a limited number of applications and parameters. Most studies of this thesis optimize diffuse reflectance spectroscopy (DRS) parameters …
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Dielectric Measurements for Organ Cryopreservation
… storage and subsequent transplantation of human organs, such as the kidney. A major difficulty in organ cryopreservation is that of obtaining rapid warming of the frozen tissue, whilst maintaining a uniform temperature profile . Before cooling, the organ is perfused with a 'cryoprotectant', a …