Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"organ function"”.
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Role of right ventricular anisotropic viscoelasticity in pathophysiology of RV failure
… markedly contribute to RV diastolic and systolic function. However, the myocardium is viscoelastic, and there is both energy storage (elasticity) and dissipation (viscosity) involved in the dynamic deformation within each cardiac cycle. Therefore, the long-ignored viscous component and its impact …
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Determination of physiologic states during mechanical circulatory support through characterization of device-organ interactions
Organ transplantation is a valuable treatment for organ failure; however, it is limited by an increasing shortage of donor organs. Because of this, mechanical support has emerged as an effective therapy to promote recovery of native organ function, especially in the setting of acute heart failure. …
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Hydrogel cell encapsulation for tissue engineering
… tissues for restoration or replacement of organ function holds the potential to alter the landscape of medical therapeutics. In many tissue engineering approaches, cells seeded within 3D porous structures are expected to remodel into tissue-like structures. Despite significant progress, …
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Das abdominelle Kompartmentsyndrom : hämodynamische, respiratorische und histologische Auswirkungen der wiederholten intraabdominellen Druckerhöhung am Tiermodell Schwein
… (IAH). Due to impairment of pulmonary function in patients with IAH mechanical ventilation is often required. Studies investigating the adult respiratory distress syndrome (ARDS) show an advantage of assisted ventilation modes (e.g. Bilevel Intermittent Positive Airway Pressure, BIPAP) …
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4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
Organ function relies on the synergistic interactions and conserved organization between all its system components. Blood, blood vessels, extracellular matrix (ECM), and parenchyma interact dynamically, existing in a state of constant cross-talk and regulation. Yet for all we have discovered about …
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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
… that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal endothelial function during oxidative stress. The vitamin C status of critically ill patients in South African ICUs has not been …
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ESTIMATING PERFUSION AND VASCULAR PROPERTIES FROM MEDICAL IMAGES: QUANTITATIVE TRANSPORT MAPPING (QTM)
… space volume, directly reflect whether the organ is under normal physical condition. Direct estimation of perfusion parameters is not feasible in most situations, as capillaries are deeply buried in human body, and invasive operations will disrupt blood flow and affect organ function. Under …
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A Proper Orthogonal Decomposition-based inverse material parameter optimization method with applications to cardiac mechanics
… to produce models of integrated tissue and organ function. This enables more sophisticated simulation tools that allows for greater insight into disease and guide the development of modern therapies. The development of realistic computer models of mechanical behaviour for soft biological …
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Meeting the oxygen requirements of an isolated perfused rat liver
Liver perfusion systems can be used as organ culture platforms for metabolic, genetic and systems engineering, tissue regeneration, pharmacokinetics, organ storage and marginal donor reconditioning for transplantation. The primary requirement of such a system is that it maintain ex vivo organ …
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Behavior and communication in the short bare-tailed opossum (Monodelphis domestica)
… Seven scent marking modes were identified which functioned to communicate individual identity and sexual advertisement. Males could distinguish sex and estrous condition of conspecific urine donors by olfaction. Dig perineal dragging, lateral side rubbing, and hip rubbing were unique to …
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DNA damage and nutrient status as risk factors for mild cognitive impairment and Alzheimer’s disease
… identify an array of important micronutrients, organ function and stress markers in plasma associated with MCI or AD diagnosis prior to medication and to compare these profiles to those observed in healthy age- and gender- matched controls (iii) To determine lipid status, including plasma …
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Ο ΠΟΛΙΤΙΚΟΣ ΕΛΕΓΧΟΣ ΤΗΣ ΣΥΝΤΑΓΜΑΤΙΚΟΤΗΤΑΣ ΤΟΥ ΝΟΜΟΥ. ΜΕΛΕΤΗ ΣΥΓΚΡΙΤΙΚΟΥ ΣΥΝΤΑΓΜΑΤΙΚΟΥ ΔΙΚΑΙΟΥ ΚΑΤΑ ΤΟ ΔΙΚΑΙΟ ΤΗΣ ΕΛΛΑΔΑΣ, ΤΗΣ ΓΑΛΛΙΑΣ ΚΑΙ ΤΗΣ ΟΜΟΣΠΟΝΔΙΑΚΗΣ ΔΗΜΟΚΡΑΤΙΑΣ ΤΗΣ ΓΕΡΜΑΝΙΑΣ
… ON THE BASIS OF THE CLASSICAL CRITERIA (ORGAN/FUNCTION) BUT ON THE BASIS OF A "BUNCH OF INDICATIONS" THAT GO BACK TO THE HISTORICAL, SOCIAL AND POLITICAL RATIO OF THE PROCEEDING CONCERNED. ON THAT BASIS WECAN QUALIFY AS POLITICAL REVIEW OF THE CONSTITUTIONALITY OF LAWS. THE CONSTITUTIONAL …
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Organ donation after death determination by circulatory criteria: Evaluation of two controversial practices
Background Organ donation may occur after death determination by neurological criteria or by circulatory criteria (DCC). This thesis evaluates two controversial practices specific to DCC: (1) antemortem heparin administration to DCC donors with the aim of improving organ function, and (2) cardiac …
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Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
… tissue formation, and ultimately complete organ function. The field of regenerative medicine aims to recreate the unique biological properties found in specific tissue types and to incorporate these properties into substrates that support long term cell function for applications including …
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Profiling Host Respiratory Responses to SARS-CoV-2 Infection
… have revealed rare cell populations critical to organ function and provide comprehensive genomic reference maps for the scientific community, and profiling of non-homeostatic tissues—across oncology, inflammation, autoimmunity, infectious disease and beyond—have revealed insights into the drivers …
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Single-cell response to perturbations across biological scales : single organ, organ system and phenotypic individuals
The biological processes that sustain a complex organism require the orchestrated dynamics of complex cellular ensembles. Several vital systems - such as the immune system, the digestive system and more - must process internal and external signals to maintain functional homeostasis in response to …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… that enable nervous system development and function we have studied the sensory organs of Caenorhabditis elegans because their anatomy and function are well-characterized. Specifically, we have focused on two aspects of sensory organs: how do glia interact with neurons to enable proper …
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Baculovirus as a gene delivery and expression vector in mammalian cells
The interior homeostasis of a solid organ, such as a kidney, is greatly altered during the surgical removal, storage and transplantation process from donor to recipient. Consequently, normal organ function may be delayed or prevented following transplantation. The main injury that organs have to …
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Characterization of Bone Pathology in Sickle Cell Disease and Therapeutic Strategies
… oxidative stress may play a role in altering organ function. Asymptomatic vascular damage begins years before clinical symptoms manifest, at which point the damage is irreversible and progresses throughout life until multi-organ occurs. Bone is highly susceptible to oxidative stress and …
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